S1 guidelines for the management of postviral conditions using the example of post-COVID-19

Wiener klinische Wochenschrift, Journal Year: 2023, Volume and Issue: 135(S4), P. 525 - 598

Published: July 1, 2023

Zusammenfassung Die vorliegende Leitlinie S1 ist die Aktualisierung und Weiterentwicklung der Long COVID: Differenzialdiagnostik Behandlungsstrategien. Sie fasst den Stand Kenntnis zu postviralen Zuständen anhand des Beispiels Long/Post COVID zum Zeitpunkt Redaktionsschlusses zusammen. Aufgrund starken Dynamik Wissensentwicklung versteht sie sich als „living guideline“. Der Schwerpunkt liegt auf praktischen Anwendbarkeit Ebene hausärztlichen Primärversorgung, geeignete Stelle für Erstzutritt primäre Betreuung Behandlung verstanden wird. gibt Empfehlungen Versorgungsgang, häufigsten Symptome, in Folge einer Infektion wie mit SARS-CoV‑2 auftreten können, therapeutischen Optionen, Patient:innenführung -betreuung sowie zur Wiedereingliederung Alltag Rehabilitation. Entsprechend Krankheitsbildes einem interdisziplinären interprofessionellen Prozess entstanden Schnittstellen Kooperationsmöglichkeiten.

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Developing a Blood Cell‐Based Diagnostic Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Peripheral Blood Mononuclear Cells

Advanced Science, Journal Year: 2023, Volume and Issue: 10(30)

Published: Aug. 31, 2023

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by debilitating that profoundly impacts patients' lives. Diagnosis of ME/CFS remains challenging, with most patients relying on self‐report, questionnaires, and subjective measures to receive a diagnosis, many never receiving clear diagnosis at all. In this study, single‐cell Raman platform artificial intelligence are utilized analyze blood cells from 98 human subjects, including 61 varying disease severity 37 healthy controls. These results demonstrate profiles can distinguish between individuals, controls, high accuracy (91%), further differentiate mild, moderate, severe (84%). Additionally, specific peaks correlate phenotypes have the potential provide insights into biological changes support development new therapeutics identified. This study presents promising approach for aiding in management be extended other unexplained chronic diseases such as long COVID post‐treatment Lyme syndrome, which share same symptoms ME/CFS.

Language: Английский

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Intrinsic factors behind long‐COVID: I. Prevalence of the extracellular vesicles

Journal of Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 124(5), P. 656 - 673

Published: May 1, 2023

Abstract It can be argued that the severity of COVID‐19 has decreased in many countries. This could a result broad coverage population by vaccination campaigns, which often reached an almost compulsory status places. Furthermore, significant roles were played multiple mutations body virus, led to emergence several new SARS‐CoV‐2 variants with enhanced infectivity but dramatically reduced pathogenicity. However, challenges associated development various side effects and their persistence for long periods exceeding 20 months as infection, or taking available vaccines against it, are spreading horizontally vertically number repercussions. For example, World Health Organization announced there more than 17 million registered cases long‐COVID (also known post‑COVID syndrome) European Union countries alone. using PubMed search engine, one find 10 000 articles have been published focusing exclusively on long‐COVID. In light these enormous ever‐increasing numbers articles, most descriptive symptoms, need know reasons behind this phenomenon raises important questions. Is caused continued presence virus one/several its components recovering individual time, urges respond way leads development? Or some latent limited related patients themselves? is it sum both? Many observations support positive answer first question, whereas others back second question typically without releasing fundamental reason/signal it. Whatever is, seems real widespread remain unclear. report opens series we will try shed underlying causes phenomenon.

Language: Английский

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Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(8), P. 1829 - 1845

Published: Jan. 3, 2024

Abstract Post-acute sequelae of COVID-19 can present as multi-organ pathology, with neuropsychiatric symptoms being the most common symptom complex, characterizing long COVID a syndrome significant disease burden for affected individuals. Several typical COVID, such fatigue, depressive and cognitive impairment, are also key features other psychiatric disorders myalgic encephalomyelitis/chronic fatigue (ME/CFS) major disorder (MDD). However, clinically successful treatment strategies still lacking often inspired by options diseases similar clinical presentations, ME/CFS. Acetylcarnitine, shortest metabolite class fatty acid metabolites called acylcarnitines one abundant blood in humans be used dietary/nutritional supplement proven efficacy MDD, ME/CFS disorders. Basic research recent decades has established general, acetylcarnitine particular, important regulators indicators mitochondrial function physiological processes neuroinflammation energy production pathways. In this review, we will compare basis fatigue-associated diseases. We review molecular mechanisms associated altered metabolism potential to interfere these therapeutic agent. Finally, current evidence propose future investigate option COVID.

Language: Английский

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Visual analysis of hotspots and trends in long COVID research based on bibliometric

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24053 - e24053

Published: Jan. 1, 2024

After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a series of symptoms may persist for long time, which is now called COVID. It was found that COVID can affect all patients with COVID-19. Therefore, has become hot topic. In this study, we used the WOS database as sample data source to conduct bibliometric and visual analysis 1765 articles over past three years through VOSviewer R package. The results show countries/authors in Europe United States America contribute most articles, their cooperation also active. Keyword co-occurrence identified four clusters, important topics including mechanism, clinical symptoms, epidemiological characteristics, management/treatment Themes such "cognitive impairment", "endothelial dysfunction", "diagnosis", "biomarkers" are likely be focus new attention coming period. addition, put forward possible research opportunities on researchers practitioners facilitate future research.

Language: Английский

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