Mal de montaña de tipo agudo, subagudo y crónico

Revista Clínica Española, Journal Year: 2020, Volume and Issue: 221(8), P. 481 - 490

Published: March 17, 2020

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Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation

Life, Journal Year: 2022, Volume and Issue: 12(3), P. 437 - 437

Published: March 16, 2022

Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O2) homeostasis, adjusting convective O2 delivery utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, undergone natural selection multiple gene regions supporting adaptive traits. Some the strongest identified highland emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF is a master regulator cellular hypoxic response, but it not only regulatory under positive selection. For instance, linked highly conserved Notch signaling are also top targets, this likely play essential roles confer tolerance. Here, we explored importance mediating response. We assessed transcriptional regulation pathway, including close cross-talk with signaling, its involvement mediation angiogenesis, metabolism, inflammation, oxidative stress, relating these functions generational adaptation.

Language: Английский

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Expedition 5300: limits of human adaptations in the highest city in the world

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 602(21), P. 5449 - 5462

Published: Dec. 26, 2023

Abstract Exposure to chronic hypobaric hypoxia imposes a significant physiological burden more than 80 million humans living above 2500 m throughout the world. Among them, 50 000 live in world's highest city, La Rinconada, located at 5000–5300 southern Peru. Expedition 5300 is first scientific and medical programme led Rinconada investigate adaptations altitude‐related health issues this unique population. Dwellers from have very high haemoglobin concentration (20.3 ± 2.4 g/dL; n = 57) those with mountain sickness (CMS) exhibit even higher concentrations (23.1 1.7 150). These values are associated large total mass blood volume, without an iron deficit. changes intravascular volumes lead substantial increase viscosity, which larger CMS patients. Despite these haematological changes, 24 h pressure monitoring essentially normal but some results suggest impaired vascular reactivity. Echocardiography revealed right heart dilatation pulmonary arterial as well left ventricle concentric remodelling grade I diastolic dysfunction. dimension function tend be severe highlanders CMS. Polygraphy evaluations reduction nocturnal pulse oxygen saturation (median SpO 2 79%), patients who also tended show desaturation index. The population of offers opportunity human responses hypoxia, altitude that probably close maximum beings can permanently tolerate presenting major issues. image

Language: Английский

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Pulmonary arterial pressure at rest and during exercise in chronic mountain sickness: a meta-analysis

European Respiratory Journal, Journal Year: 2019, Volume and Issue: 53(6), P. 1802040 - 1802040

Published: April 25, 2019

Up to 10% of the more than 140 million high-altitude dwellers worldwide suffer from chronic mountain sickness (CMS). Patients suffering this debilitating problem often display increased pulmonary arterial pressure (PAP), which may contribute exercise intolerance and right heart failure. However, there is little information on usual PAP in these patients. We systematically reviewed meta-analysed all data published English or Spanish until June 2018 echocardiographic estimations at rest during mild CMS Nine studies comprising 287 participants fulfilled inclusion criteria. At rest, point estimate meta-analysis mean systolic was 27.9 mmHg (95% CI 26.3–29.6 mmHg). These values are 11% (+2.7 mmHg) higher those previously apparently healthy dwellers. During (50 W) difference between patients markedly accentuated (48.3 versus 36.3 rest. findings indicate that with moderately but exercise, will be common activities daily living.

Language: Английский

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Acute, subacute and chronic mountain sickness

Revista Clínica Española (English Edition), Journal Year: 2020, Volume and Issue: 221(8), P. 481 - 490

Published: Nov. 2, 2020

Language: Английский

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