Revista Clínica Española (English Edition), Journal Year: 2022, Volume and Issue: 222(9), P. 567 - 567
Published: May 13, 2022
Language: Английский
Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)
Published: June 20, 2024
Language: Английский
Citations
26
Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122319 - 122319
Published: Nov. 29, 2023
Language: Английский
Citations
23
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 212, P. 505 - 519
Published: Jan. 9, 2024
Language: Английский
Citations
15
European Journal of Pharmacology, Journal Year: 2022, Volume and Issue: 925, P. 175015 - 175015
Published: May 11, 2022
Language: Английский
Citations
26
Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13
Published: Oct. 20, 2022
The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory nervous systems. kidneys have an abundant blood supply (20%-25% cardiac output) high flow; thus, they are susceptible to hypoxia. However, acute chronic exposure altitudes renal physiology pathology not fully understood. Moreover, few studies investigated impact patients with kidney disease or injury. In this review, we summarized changes in due as well existing diseases, aim informing prevention treatment diseases at altitudes.
Language: Английский
Citations
24
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116793 - 116793
Published: May 21, 2024
High-altitude myocardial injury (HAMI) represents a critical form of altitude illness for which effective drug therapies are generally lacking. Notoginsenoside R1, prominent constituent derived from Panax notoginseng, has demonstrated various cardioprotective properties in models ischemia/reperfusion injury, sepsis-induced cardiomyopathy, cardiac fibrosis, and injury. The potential utility notoginsenoside R1 the management HAMI warrants prompt investigation. Following successful construction model, series experimental analyses were conducted to assess effects at dosages 50 mg/Kg 100 mg/Kg. results indicated that exhibited protective against hypoxic by reducing levels CK, CK-MB, LDH, BNP, leading improved function decreased incidence arrhythmias. Furthermore, was found enhance Nrf2 nuclear translocation, subsequently regulating SLC7A11/GPX4/HO-1 pathway iron metabolism mitigate ferroptosis, thereby mitigating inflammation oxidative stress induced high-altitude conditions. In addition, application ML385 confirmed involvement translocation therapeutic approach HAMI. Collectively, advantageous impacts on have been linked suppression ferroptosis via signaling.
Language: Английский
Citations
5
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: June 4, 2024
Background and objectives Acute mountain sickness (AMS) is a pathology with different symptoms in which the organism not adapted to environment that occurs under special of high altitude. Its main mechanism organism’s tissue damage caused by acute hypobaric hypoxia. Traditional Chinese medicine (TCM) theory focuses on holistic concept. TCM has made remarkable achievements treatment many sicknesses. This review outlines pathogenesis AMS modern traditional medicine, progress animal models AMS, summarizes therapeutic effects AMS. Methods Using keywords “traditional medicine,” “herbal “acute sickness,” “high-altitude pulmonary edema,” cerebral hypoxia,” “high-altitude,” all relevant literature published up November 2023 were collected from Scopus, Web Science, PubMed, China National Knowledge Infrastructure databases, key information was analyzed. Results We systematically summarised hypoxia tissues organism, study methodology for establishment an model retrieved 18 proprietary medicines clinical The principle mainly invigorating qi, activating blood removing stasis. components botanical drugs include salidroside, ginsenoside Rg1, tetrahydrocurcumin. action through regulation HIF-1α/NF-κB signaling pathway, inhibition inflammatory response oxidative stress, enhancement energy metabolism. Conclusion unclear. Still, formulas have been used treat multifaceted interventions, such as compound danshen drip pills, Huangqi Baihe granules, Rg1. These generally exert anti-AMS pharmacological inhibiting expression VEGF, concentration MDA pro-inflammatory factors, down-regulating NF-κB/NLRP3 promoting SOD Na + -K -ATPase activities, attenuates hypoxia-induced injury. comprehensively analyses application makes suggestions more in-depth studies future, aiming provide some ideas insights subsequent studies.
Language: Английский
Citations
5
Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: May 10, 2023
Introduction Hypoxia-induced neuronal damage is the primary cause of cognitive impairment induced by high-altitude exposure. Microglia play a crucial regulatory role in central nervous system (CNS) homeostasis and synaptic plasticity. M1-type polarized microglia are suspected to be responsible for CNS injury under hypoxic conditions, but exact molecular mechanism still unelucidated. Methods CX3CR1 knock out wide type mice were exposed simulated plateau at 7000 m 48 h construct model hypobaric hypoxia-induced memory impairment. The was assessed Morris water maze. dendritic spine density hippocampus examined Golgi staining. synapses CA1 region number neurons DG immunofluorescence activation phagocytosis immunofluorescence. levels CX3CL1/CX3CR1 their downstream proteins detected. knockout treated with CX3CL1 combined 1% O 2 . related microglial polarization, uptake synaptosome phagocytotic ability Results In this study, altitude developed significant amnesia recent memories, no change anxiety observed. Hypobaric hypoxia exposure (7000 above sea level h) resulted synapse loss hippocampus, changes occurred total neurons. Meanwhile, activation, increased microglia, signal observed Further, we found that after exposure, CX3CR1-deficient showed less amnesia, region, increase M1 compared wildtype siblings. did not exhibit polarization response either or induction. Both through upregulation phagocytosis. Discussion current study demonstrates mediates upregulates phagocytosis, which increases causing inducing forgetting.
Language: Английский
Citations
11
Mammalian Genome, Journal Year: 2023, Volume and Issue: 34(1), P. 76 - 89
Published: Feb. 10, 2023
Language: Английский
Citations
7
Journal of the Formosan Medical Association, Journal Year: 2024, Volume and Issue: 123(11), P. 1161 - 1166
Published: Feb. 7, 2024
Acute mountain sickness (AMS) is initiated in response to a hypoxic and hypobaric environment at high altitude. The precise prevalence of AMS Jade Mountain climbers remained largely unknown, particularly data obtained from real medical consultations. An overnight stay the Pai-Yun Lodge (3402 m) usually required before an ascent Mountain. Since 2004, Clinic has been established Lodge. provided regular emergency service every weekend. We conducted retrospective study by using records between 2018 2019. A total 1021 patients were enrolled, with 56.2 % males. Different age groups 3.2 %, 54.5 37.9 4.4 <20, 20−39, 40−59, ≥60 years, respectively. There 582 (57.0 %) diagnosed have (230 [39.5 %] mild type 352 [60.5 severe type). factors associated development included young age, absence climbing history (>3000 within last 3 months, first experience, taking preventive medication, low oxygen saturation, Lake Louise score (LLAMSS). severity LLAMSS. Approximately 15 needed service, which 60 had AMS. must require supply or medication prescription. Oxygen saturation measure LLAMSS evaluation are reasonable tools predict occurrence on
Language: Английский
Citations
2