Impact of sex on the cerebrovascular response to incremental aerobic exercise in moderately trained endurance athletes DOI

Nassif Chamoun,

Audrey Drapeau,

Lawrence Labrecque

et al.

Journal of Applied Physiology, Journal Year: 2023, Volume and Issue: 134(6), P. 1470 - 1480

Published: April 27, 2023

The cerebrovascular response to incremental aerobic exercise is comparable between males and females. Whether this can be found in moderately trained athletes remains unknown. We aimed examine the effect of sex on until volitional exhaustion population. Twenty-two (11 M/11 F; age: 25 ± 5 vs. 26 6 yr, P = 0.6478; peak oxygen consumption: 55.8 5.2 48.3 4 mL/kg/min; 0.0011; training volume: 532 173 466 151 min/wk, 0.3554) performed a maximal ergocycle test. Systemic hemodynamics were measured. At rest, middle cerebral artery mean blood velocity (MCAvmean; 64.1 12.7 72.2 15.3 cm·s-1; 0.2713) was not different groups, whereas partial pressure end-tidal carbon dioxide ([Formula: see text], 42 3 37 2 mmHg, 0.0002) higher males. During MCAvmean ascending phase, changes (intensity: < 0.0001, sex: 0.3184, interaction: 0.9567) groups. Changes cardiac output text]) 0.0001) [Formula: text] descending 0.5522, 0.4828) 0.0550, 0.0003, 0.2715) (intensity 0.0280) These results suggest during females notwithstanding differences key flow determinants.NEW & NOTEWORTHY study endurance-trained spite arterial compared with exhaustion. This could help providing better understanding regulation exercise.

Language: Английский

Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo DOI
Qinrui Fu, Xiao Yang, Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

Citations

31
Physiological Function during Exercise and Environmental Stress in Humans—An Integrative View of Body Systems and Homeostasis DOI Creative Commons
Gavin Travers, Pascale Kippelen, Steven J. Trangmar

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(3), P. 383 - 383

Published: Jan. 24, 2022

Claude Bernard's

Language: Английский

Citations

36
Designing of multifunctional graphene quantum dot-polyvinyl alcohol-polyglycerol luminescent film for fluorescence detection of pH in sweat DOI

Qingqing Xie,

Ruiyi Li, Zaijun Li

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1292, P. 342224 - 342224

Published: Jan. 9, 2024

Language: Английский

Citations

8
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function DOI Creative Commons
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(21), P. 5659 - 5684

Published: Feb. 13, 2024

Abstract We examined the extent to which apnoea‐induced extremes of oxygen demand/carbon dioxide production impact redox regulation cerebral bioenergetic function. Ten ultra‐elite apnoeists (six men and four women) performed two maximal dry apnoeas preceded by normoxic normoventilation, resulting in severe end‐apnoea hypoxaemic hypercapnia, hyperoxic hyperventilation designed ablate hypoxaemia, hyperoxaemic hypercapnia. Transcerebral exchange ascorbate radicals (by electron paramagnetic resonance spectroscopy) nitric oxide metabolites tri‐iodide chemiluminescence) were calculated as product global blood flow duplex ultrasound) radial arterial (a) internal jugular venous (v) concentration gradients. Apnoea duration increased from 306 ± 62 s during hypercapnia 959 201 ( P ≤ 0.001). generally (all 0.001) but was insufficient prevent a reduction metabolic rates glucose = 0.015–0.044). This associated with general net output (v > a) that greater 0.046 vs . hypercapnia) coincided selective suppression plasma nitrite uptake (a v) 0.034 <0.001 hypercapnia), implying reduced consumption delivery consistent elevated oxidative–nitrosative stress. In contrast, we failed observe equidirectional gradients S ‐nitrosohaemoglobin ‐nitrosothiol apnoea ≥ 0.05). Collectively, these findings highlight key catalytic role for image Key points Local sampling across circulation determined (prior normoventilation) hyperventilation) free radical‐mediated bioavailability suppressed consumption, thereby reducing The elevation glucose. Cerebral stress compared lower flow, highlighting hypoxaemia. applied model voluntary human asphyxia might have broader implications management treatment neurological diseases characterized demand carbon production.

Language: Английский

Citations

8
Neurovascular coupling and CO2 interrogate distinct vascular regulations DOI Creative Commons
Marine Tournissac, Emmanuelle Chaigneau, Sonia Pfister

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 2, 2024

Abstract Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow response to neuronal activation, is commonly used map brain activation or dysfunction. Here we tested the reemerging hypothesis that CO 2 generated by metabolism contributes NVC. We combined functional ultrasound and two-photon imaging mouse barrel cortex specifically examine onsets of local changes vessel diameter, dynamics, vascular/perivascular/intracellular pH, intracellular calcium signals along vascular arbor a short strong challenge (10 s, 20%) whisker stimulation. report brief hypercapnia reversibly acidifies all cells arteriole wall periarteriolar space 3–4 s prior dilation. During this prolonged lag period, NVC triggered stimulation not affected acidification entire neurovascular unit. As it also persists under condition continuous inflow , conclude involved

Language: Английский

Citations

8
Evidence for direct CO2‐mediated alterations in cerebral oxidative metabolism in humans DOI Creative Commons
Hannah G. Caldwell, Ryan L. Hoiland, Anthony R. Bain

et al.

Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(9)

Published: July 3, 2024

How the cerebral metabolic rates of oxygen and glucose utilization (CMRO

Language: Английский

Citations

4
Early Microcirculatory Dysfunction on Perfusion CT Is Related to Prognosis After Aneurysmal Subarachnoid Hemorrhage DOI
Sijia Li, Lei Wu, Ning Li

et al.

Translational Stroke Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel DOI Creative Commons
Jay M. J. R. Carr, Philip N. Ainslie, Trevor A. Day

et al.

Experimental Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (), owing to its effect on cerebral blood flow, tissue , proton concentration, metabolism and cognitive neuronal function. In normal environments in absence pathology, at least over acute time frames, hypercapnia usually managed readily via respiratory chemoreflex arcs and/or acid–base buffering capacity, such that there minimal impact cerebrovascular neurological However, non‐normal environments, as enclosed spaces, or with extended exposures elevations can be detrimental health. Given direct protons cellular function, even if pH normalized, it feasible higher concentrations could still produce effects. Although seems humans work safely mildly hypercapnic for periods, chronic acidosis cause bone demineralization, renal calcification, perinatal developmental abnormalities, systemic inflammation impairments function visuomotor skills acidosis, potentially inducing sustained alterations With advancement new initiatives spaceflight, including proposed long‐duration missions Mars, study effects inspired CO 2 human health relevant. this review, we draw evidence from preclinical, physiological clinical research summarize ramifications prolonged elevated pressures acidosis.

Language: Английский

Citations

0
The Influence of Different Arterial Carbon Dioxide Levels on the Cerebrovascular Autoregulation Curve in a Porcine Cranial Window Model DOI
Sofie Dietvorst, Bavo Kempen,

Veerle De Sloovere

et al.

Neurocritical Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila DOI Creative Commons
Andres Flores-Valle,

Ivan Vishniakou,

Johannes D. Seelig

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Homeostatic processes, including sleep, are critical for brain function. Here we identify astrocyte-like glia (or astrocytes, AL) and ensheathing (EG), the two major classes of that arborize inside brain, as brain-wide, locally acting homeostats short, naturally occurring rest sleep bouts Drosophila , show a subset neurons in fan-shaped body encodes feeding homeostasis. We metabolic gas carbon dioxide, changes pH behavioral activity all induce long-lasting calcium responses EG AL, levels both types circadian modulation. The homeostatic dynamics these can be modeled based on behavior. Additionally, local optogenetic activation AL or is sufficient to rest. Together, results suggest glial controllers activity, thus establishing link between metabolism, sleep.

Language: Английский

Citations

0