Poly β-Cyclodextrin/Quaternary Ammoniated Chitosan Cryogel with a Porous Structure for Effective Hemostasis

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(2), P. 1077 - 1088

Published: Jan. 9, 2023

Uncontrolled bleeding is one of the most important causes threatening human health, but quick hemostasis remains a challenge. We prepared porous cryogels with poly β-cyclodextrin (Pβ-CD) and quaternary ammoniated chitosan (QCs). Pβ-CD acts as "water-grabbing agent" to assist QCs' ability absorb concentrate blood rapidly. The rat-tail amputation model liver injury exhibited that had excellent hemostatic performance. Moreover, showed good antibacterial activity biocompatibility. Therefore, these can be used potential materials.

Language: Английский

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Relationship between serum bicarbonate levels and the risk of death within 30 days in ICU patients with acute ischemic stroke

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: May 24, 2023

To explore the relationship between baseline bicarbonate levels and their changes with 30-day mortality in patients acute ischemic stroke who were admitted to intensive care unit (ICU).This cohort study collected data of 4,048 participants from Medical Information Mart for Intensive Care (MIMIC)-III MIMIC-IV databases. Univariate multivariable Cox proportional risk models utilized T0 Δbicarbonate stroke. The Kaplan-Meier curves plotted measure survival probability stroke.The median follow-up time was 30 days. At end follow-up, 3,172 survived. Bicarbonate ≤ 21 mEq/L [hazard ratio (HR) = 1.24, a 95% confidence interval (CI): 1.02-1.50] or < 23 (HR 1.29, 95%CI: 1.05-1.58) associated an increased compared > 26 mEq/L. -2 0 1.40, 1.14-1.71), 2 1.44, 1.17-1.76), >2 1.15-1.71) correlated elevated patients. mEq/L, >26 higher than that greater group those group.Low decreased during ICU stay high Special interventions should be offered low stay.

Language: Английский

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Development of a piglet model for cerebrovascular autoregulation assessment with altered PaCO2

Brain and Spine, Journal Year: 2024, Volume and Issue: 4, P. 102833 - 102833

Published: Jan. 1, 2024

Cerebrovascular autoregulation (CA) capacity can be impaired in the aftermath of acute brain injuries. Altered physiological states, such as hypo- and hypercapnia, affect CA. Although these effects have been demonstrated several animal experiments, exact effect PaCO₂ on plateau cerebral blood flow (CBF) across spectrum arterial pressures has not fully disclosed.

Language: Английский

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Photoacoustic Microscopic Imaging of Cerebral Vessels for Intensive Monitoring of Metabolic Acidosis

Molecular Imaging and Biology, Journal Year: 2023, Volume and Issue: 25(4), P. 659 - 670

Published: March 31, 2023

Language: Английский

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Dynamics of sleep and feeding homeostasis inDrosophilaglia and neurons

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 7, 2022

Abstract Sleep is critical for homeostatic processes in the brain, including metabolism and waste removal. Here, we identify brain-wide, locally acting sleep homeostats short, naturally occurring bouts of Drosophila two major classes glia that arborize inside astrocytes ensheathing glia. We show surround respiratory tracheal tubes, metabolic gas carbon dioxide, changes pH, or behavioral activity, all induce long lasting calcium responses, circadian modulations. Glia describe homeostasis behaving flies more faithfully than previously identified circuits central complex, but a subset neurons fan-shaped body important feeding homeostasis. Local optogenetic activation sufficient to sleep. Together, levels can be modeled as controllers thus establishing link between

Language: Английский

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Cerebral O₂ and CO₂ transport in isovolumic haemodilution: Compensation of cerebral delivery of O₂ and maintenance of cerebrovascular reactivity to CO₂

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2022, Volume and Issue: 43(1), P. 99 - 114

Published: Sept. 21, 2022

This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) 11 healthy males (age; 28 ± 7 years: body mass index; 23 2 kg/m2). Radial artery internal jugular vein catheters provided measurement pressure gases, quantification metabolism, washout, trans-cerebral nitrite exchange (ozone based chemiluminescence). Prior to following haemodilution, partial (PaCO2) was elevated with dynamic end-tidal forcing while gCBF measured duplex ultrasound. CVR determined as slope response PaCO2. Replacement ∼20% volume an equal 5% human serum albumin (Alburex® 5%) reduced haemoglobin (13.8 0.8 vs. 11.3 0.6 g/dL; P < 0.001) CaO2 (18.9 1.0 vs 15.0 mL/dL 0.001), (+18 11%; = 0.002), preserved oxygen delivery (P 0.49), washout (+11%; 0.01). The net uptake (11.6 14.0 nmol/min; 0.027) at baseline abolished (-3.6 17.9 0.54), perhaps underpinning conservation (61.7 19.0 69.0 19.2 mL/min/mmHg; 0.23). These findings demonstrate that responses anaemia humans are sufficient support maintenance CVR.

Language: Английский

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Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8

Translational Stroke Research, Journal Year: 2023, Volume and Issue: 15(3), P. 620 - 635

Published: Feb. 28, 2023

Language: Английский

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Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 779 - 779

Published: April 30, 2023

Insulin resistance is one of the etiologies type 2 diabetes mellitus (T2DM) and has been suggested to contribute development Alzheimer’s disease by promoting amyloid-β accumulation. Various causes insulin have suggested; however, mechanisms remain be elucidated in many respects. Elucidating underlying key factors developing methods prevent onset T2DM disease. It that body pH environment plays an important role control cellular functions regulating action hormones including activity enzymes neurons, thereby maintaining homeostatic conditions body. This review introduces: (1) Mitochondrial dysfunction through oxidative stress caused obesity-induced inflammation. (2) Decreased interstitial fluid due mitochondrial dysfunction. (3) Development diminution affinity its receptor lowered pH. (4) Accelerated accumulation elevated activities β- γ-secretases (5) Diet therapies for improving with weak organic acids act as bases raise food promote absorption gut.

Language: Английский

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Assessment of Cerebrovascular Reactivity Using CO₂‐BOLD MRI: A 15‐Year, Single Center Experience

Journal of Magnetic Resonance Imaging, Journal Year: 2023, Volume and Issue: 60(3), P. 954 - 961

Published: Dec. 22, 2023

Background Cerebrovascular reactivity (CVR) is a measure of the change in cerebral blood flow (CBF) response to vasoactive challenge. It useful indicator brain's vascular health. Purpose To evaluate factors that influence successful and unsuccessful CVR examinations using precise arterial end‐tidal partial pressure CO 2 control during oxygen level–dependent (BOLD) MRI. Study Type Retrospective. Subjects Patients underwent between October 2005 May 2021 were studied (total 1162 examinations). The mean (±SD) age was 46.1 (±18.8) years, 352 patients (43%) female. Field Strength/Sequence 3 T; T1‐weighted images, T2*‐weighed two‐dimensional gradient‐echo sequence with standard echo‐planar readout. Assessment Measurements obtained following hypercapnic stimuli BOLD MRI as surrogate CBF. Successful defined those where: 1) able complete testing, 2) clinically map generated. Unsuccessful where not examination or maps judged be unreliable due to, for example, excessive head motion, poor P ET targeting. Statistical Analysis stimuli, different patterns stimulus compared Chi‐Square tests. Interobserver variability determined by intraclass correlation coefficient ( < 0.05 significant). Results In total 1115 tests 662 included final analysis. success rate generating 90.8% (1012 1115). Among containing step plus ramp protocol most (95.18%). (9.23%), patient related (89.3%), common which difficulty breathing. Data Conclusion ‐BOLD studies are well tolerated high rate. Evidence Level 4 Technical Efficacy Stage

Language: Английский

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Severe traumatic brain injury: acute treatment based on cerebral perfusion pressure

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Severe traumatic brain injury is a cause of disability with economic and social repercussions. Prehospital care fundamental part important attention to avoid hypoxemia, hyperventilation, hypotension airway protection. During the primary evaluation, clinical examination performed focused on classifying according their severity, neurological involvement, extracranial lesions providing prognosis. Invasive or non-invasive intracranial pressure monitoring aims direct management maintain adequate cerebral perfusion pressure, which should be individualized in each patient, as this depends status self-regulation.

Language: Английский

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