The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(13), P. 2537 - 2539
Published: May 22, 2023
The special issue of Journal Physiology entitled ‘Cell diversity and signalling in the cardiovascular system’ is outcome 7th UC Davis Cardiovascular Symposium, which was held on 25 26 March 2022 brought together leading experts from around world to share their insights this important rapidly evolving area research. symposium highlighted critical role cellular maintaining health, need understand complex interplay between cells pathways both health disease. includes a white paper, review six original research papers, as well corresponding perspective articles providing expert commentary analysis latest exciting findings field. paper provides comprehensive overview state art cell research, highlighting key identifying areas where more work needed (Grandi et al., 2023). article examines myocytes non-myocyte heart vasculature how they interact with other types maintain normal function. A (Kass, 2023) highlights significance surveying involved function, complexity that exists at subcellular, system levels, importance technological advancements enable exploration diversity, ultimately enhances our understanding integrated function dysfunction. As such, serves resource not only for investigators field physiology but also those seeking relevant references reviewing field, regardless specialization topical by Salameh al. (2023) delves into developmental progression human heart, specific emphasis its structure, electrophysiology, metabolic profile contractile While making helpful comparisons animal models cardiac development, primarily focuses tissue samples, thus offers unique detailed authors identify limited number publications samples major limitation, studies better paediatric cardiomyocyte physiology. These are essential expand knowledge pathophysiology will help improve clinical care guiding development age-appropriate treatment strategies disease (Salameh papers tackle wide range topics related system, identification characterization novel interactions arrhythmia subcellular ionic processes modulating responses stressors. provide multiscale landscape blood vessels, shedding light mechanisms underlying physiological pathological processes. Chowkwale introduce computational framework enables modelling dynamics immune cell–fibroblast context myocardial infarction. Through calibration validation against existing datasets mice, model successfully predicts several biological parameters wound healing, such cytokine secretion, phagocytosis content. Moreover, utilized investigate factors contribute inflammation onset resolution. Model predictions establish concept inflammation–fibrosis coupling: study's highlight intriguing connections infarct size, neutrophil content collagen deposition, an IL-1β-mediated mechanism implicated these interactions. can be further explored experimentally rationale designing new therapeutics response after Indeed, proposed promising prospects future experimental joint modelling–experimental investigations. Zhang developed rigorously validated multi-scale simulated electrical activity calcium atrial myocytes. provided quantitative crucial architecture (i.e. transverse-axial tubular system) regulating potential impact arrhythmogenesis (Zhang, Ni allowed investigation various concomitant disease-associated factors, changes ion channel distribution remodelling, interaction remodelling Smith This active ultrastructure has been shown play propagation signals regulation handling contraction during (Manfra 2023), pathophysiology. An accompanying editorial approaches address unresolved questions about relative suitability antiarrhythmic targets (Heijman & Dobrev, notion structural electrophysiological intricately linked nicely demonstrated recent elucidating fibrotic repolarization heterogeneity ventricular risk aged spontaneously hypertensive rats (Khwaounjoo 2022). suggested translational perspective, likely reflect balance macro-structure functional control, whereby neural might regulatory setting scars (Shivkumar In study included issue, Gibbs explore graft–host connectivity conductivity graft-initiated arrhythmias pluripotent stem cell-derived grafts within infarcted ventricle. results suggest spatiotemporally heterogeneous coupling create milieu favours host excitation. hold domain shed regions greater arrhythmia. created could serve guide targeted graft implantation avoid high-risk areas. Meier present approach electrophysiology introducing integrates ion-channel trafficking, currently accounted models. temperature- drug-dependent effects Kv11.1 (hERG) kinetics allowing sophisticated behaviour. reveals mutations, temperature medications affecting KV11.1 trafficking gating across different time scales. silico marks significant advance action potential, (Burgess Delisle, pioneering effort represents initial step modulation arrhythmogenesis, extending beyond electrogenic proteins. Raph describes mesenteric tone regulation, specifically investigating contribution voltage-gated K+ channels (Kv) vasodilation resistance arteries induced lactate hydrogen peroxide. propose dehydrogenase-mediated synthesis NADH causes increasing open probability Kv1 channel. They H2O2 increase activity, synergetic effect blocked Kv1.5-subunit Kvβ1:β2 ratio. enrich intestinal flow, local adaptation general vessel contractility. broader context, brings act hub integrating multiple redox regulate arterial diameter flow. Together, offer rich diverse collection topics, including interactions, influence expression vascular reactivity, arrhythmogenic ultrastructural arrhythmias. emphasize coordinating crosstalk Physiology. For example, Dokshokova (2022) showed cardiomyocytes sympathetic neurons participate bidirectional communication, directly innervation may pathophysiological denervation another article, proinflammatory T accumulation aorta age-induced endothelial dysfunction stiffening (Trott 2021). Several demonstrate power integrate data spatial temporal scales quantitatively mechanistic underpinnings Other examples include Gharahi (2022), who mathematical vivo haemodynamics probe regulation. theoretical optogenetic control were used design optimization enhancement (Pyari Along lines, discusses developments computer vision algorithms ratiometric techniques employed overcome limitations conventional optical mapping non-contracting hearts (Kappadan have valuable insight intricate mechano–electrical coupling. Further, measurements, non-invasive coherence tomography-based visualize quantify microvascular structure (Sciarrone 2022), powerful tools characteristics living organisms. growing body literature system’. avenues therapeutic disease, fundamental govern Please note: publisher responsible or functionality any supporting information supplied authors. Any queries (other than missing content) should directed author article. None. Sole author. author's funded National Institutes Health: R13HL162430, R01HL131517, R01HL141214, 1OT2OD026580-01, P01HL141084.
Language: Английский
