Ultrasound system for precise neuromodulation of human deep brain circuits

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Abstract Transcranial ultrasound stimulation (TUS) has emerged as a promising technique for non-invasive neuromodulation, but current systems lack the precision to target deep brain structures effectively. Here, we introduce an advanced TUS system that achieves unprecedented in neuromodulation. The features 256-element, helmet-shaped transducer array operating at 555 kHz, coupled with stereotactic positioning system, individualised treatment planning, and real-time monitoring using functional MRI. In series of experiments, demonstrate system’s ability selectively modulate activity lateral geniculate nucleus (LGN) its functionally connected regions visual cortex. Participants exhibited significantly increased cortex during concurrent stimulation, high reproducibility across individuals. Moreover, theta-burst protocol induced robust neuromodulatory effects, decreased observed least 40 minutes post-stimulation. These effects were specific targeted LGN, confirmed by control experiments. Our findings highlight potential this non-invasively circuits specificity, offering new avenues studying function developing therapies neurological psychiatric disorders. spatial resolution prolonged transformative technology both research clinical applications, paving way era

Language: Английский

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Exploiting Polynomial Chaos Expansion for Rapid Assessment of the Impact of Tissue Property Uncertainties in Low‐Intensity Focused Ultrasound Stimulation

Bioelectromagnetics, Journal Year: 2025, Volume and Issue: 46(3)

Published: March 12, 2025

ABSTRACT Neuromodulation with low‐intensity focused ultrasound (LIFUS) holds significant promise for noninvasive treatment of neurological disorders, but its success relies heavily on accurately targeting specific brain regions. Computational model predictions can be used to optimize LIFUS, uncertain acoustic tissue properties affect prediction accuracy. The Monte Carlo method is often quantify the impact uncertainties, many iterations are generally needed accurate estimates. We studied a surrogate based polynomial chaos expansion (PCE) uncertainty in LIFUS intensity field caused by property uncertainties. PCE approach was benchmarked against three different head models. also investigated effect number samples accuracy model. Our results show that requires only 20 simulation estimate mean and standard deviation high compared 100 method. root squared percentage error (RMSPE) less than 1.5%, maximum 0.5 W/cm 2 (< 1% focus peak water), while RMSPE 9%, 0.3 . model, limited it makes promising tool quantifying applications.

Language: Английский

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A head template for computational dose modelling for transcranial focused ultrasound stimulation

NeuroImage, Journal Year: 2023, Volume and Issue: 277, P. 120227 - 120227

Published: June 15, 2023

Transcranial focused Ultrasound Stimulation (TUS) at low intensities is emerging as a novel non-invasive brain stimulation method with higher spatial resolution than established transcranial methods and the ability to selectively stimulate also deep areas. Accurate control of focus position strength TUS acoustic waves important enable beneficial use high ensure safety. As human skull causes strong attenuation distortion waves, simulations transmitted are needed accurately determine dose distribution inside cranial cavity. The require information morphology its properties. Ideally, they informed by computed tomography (CT) images individual head. However, suited imaging data often not readily available. For this reason, we here introduce validate head template that can be used estimate average effects on wave in population. was created from CT heads 29 individuals different ages (between 20-50 years), gender ethnicity using an iterative non-linear co-registration procedure. validation, compared thermal based simulation results all datasets. Acoustic were performed for model transducer driven 500 kHz, placed 24 standardized positions means EEG 10-10 system. Additional 250 kHz 750 16 further confirmation. amount ultrasound-induced heating estimated same positions. Our show represents median pressure temperature maps reasonably well most cases. This underpins usefulness planning optimization interventions studies healthy young adults. indicate variability between depends position. Specifically, simulated exhibited interindividual three posterior close midline, caused local shape composition. should taken into account when interpreting template.

Language: Английский

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Strategies and safety simulations for ultrasonic cervical spinal cord neuromodulation

Physics in Medicine and Biology, Journal Year: 2024, Volume and Issue: 69(12), P. 125011 - 125011

Published: May 24, 2024

. Focused ultrasound spinal cord neuromodulation has been demonstrated in small animals. However, most of the tested neuromodulatory exposures are similar intensity and exposure duration to reported animal threshold for possible damage. All efforts must be made minimize risk assure safety potential human studies, while maximizing treatment efficacy. This requires an understanding propagation heat deposition within spine.

Language: Английский

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