Habituation of the biological response to repeated psychosocial stress: a systematic review and meta-analysis

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 105996 - 105996

Published: Jan. 1, 2025

Recurrent psychosocial stress poses a significant health challenge, prompting research into mechanisms of successful adaptation. Physiological habituation, defined as decreased reactivity to repeated stressors, is pivotal in protecting the organism from allostatic load. Here, we systematically review and meta-analyze data studies investigating capacity central systems habituate when repeatedly exposed standardized stressor, Trier Social Stress Test (k=47). For comprehensive overview biological systems, examine multiple markers hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), immune system. Our findings indicate that habituation patterns vary substantially between different systems. While most provide robust evidence for rapid substantial HPA-axis ANS marker responses are less uniform. We further integrate existing knowledge on personal environmental influences contributing individual differences capacity. Additionally, discuss implications outcomes design longitudinal highlight potential avenues future research.

Language: Английский

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Acute Stress and Autoimmune Markers: Evaluating the Psychoneuroimmunology Axis in Firefighter Recruits

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3945 - 3945

Published: April 22, 2025

Chronic psychological stress is known to influence immune function and contribute development of autoimmune disorders through dysregulated inflammatory responses. This study investigates relationships between acute stress, life trauma, salivary biomarkers in firefighter recruits during psychophysical training. Salivary samples were collected from two tests evaluate responses stress. Samples obtained at three time points—pre-stress, post-stress, recovery—across both tests. Cortisol was measured characterize response (ASR) profiles, while assessed the analyzing C-reactive Protein (CRP), Complement C4 (C4), Pigment Epithelium Derived Factor (PEDF), Serum Amyloid P (SAP). Results showed significant changes CRP, C4, PEDF after inoculation. Higher previous trauma associated with lower baseline cortisol (r = −0.489) delay recovery 0.514), suggesting a learned biological response, potentially protective against stress-induced dysregulation. Cluster analysis revealed four distinct ASR profiles which found have significantly different past (p 0.031). These findings suggest that history influences biomarker dynamics, reflecting individualized adaptive or maladaptive The insights gained may inform strategies enhance resilience mitigate risk among high-stress populations.

Language: Английский

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Lifetime adversity predicts depression, anxiety, and cognitive impairment in a nationally representative sample of older adults in the United States

Journal of Clinical Psychology, Journal Year: 2024, Volume and Issue: 80(5), P. 1031 - 1049

Published: Jan. 31, 2024

Abstract Objective Although life stress and adversity are well‐known risk factors for mental health problems cognitive impairment among older adults, limited research has comprehensively examined the impact of both childhood adulthood on psychiatric symptoms over a prolonged period. To address this issue, we investigated how lifetime exposure is related to depression, anxiety, in nationally representative, longitudinal sample adults United States. Method We analyzed data from Health Retirement Study (1992–2016). The included 3496 individuals (59.9% female), aged ≥64 years old ( M age = 76.0 ± 7.6 2016). used individual‐level panel ordinary least squares regressions estimate associations between adversities, later‐life impairment. Results Many participants experienced significant early (38%) or (79%) stressor. Moreover, experiencing one (vs. none) was associated with 17.4% increased adversity. Finally, as hypothesized, more depression anxiety later life, whereas stressor predicted well symptoms. Discussion These findings demonstrate adults. Screening stressors may thus help healthcare professionals policymakers identify who could potentially benefit interventions designed reduce enhance resilience.

Language: Английский

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Hormonal contraceptive use is associated with differences in women’s inflammatory and psychological reactivity to an acute social stressor

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 115, P. 747 - 757

Published: Oct. 31, 2023

Women using hormonal contraceptives (HCs) exhibit numerous signs of chronic inflammation, including elevated C-reactive protein levels and greater risk developing mood autoimmune disorders. However, users non-users HCs often have similar circulating proinflammatory cytokine levels, making the mechanism association unclear. One possible explanation for this paradox is that HC differences in their inflammatory responses to psychosocial stress that, over time, could contribute inflammation its pathologies. Here, we tested possibility by examining women's glucocorticoid, inflammatory, psychological Trier Social Stress Test (TSST) 67 naturally cycling (NC) 60 oral HC-using women (M

Language: Английский

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