The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(2)

Published: Jan. 5, 2023

Abstract Background Neuropathic pain (NP) caused by the injury or dysfunction of nervous system is a chronic state accompanied hyperalgesia, and available clinical treatment relatively scarce. Hyperalgesia mediated pro‐inflammatory factors chemokines plays an important role in occurrence maintenance NP. Data Therefore, we conducted systematic literature review experimental NP (PubMed Medline), order to find mechanism inducing central sensitization explore intervention methods hyperalgesia real simulated injury. Result In this review, sorted out activation pathways microglia, astrocytes neurons, process crosstalk among them. It was found that NP, microglia P2X4 receptor key target, which can activate mitogen‐activated protein kinase pathway inward then outwardly neuronal tropomyosin B neurons. At same time, activated neurons continue maintain through on CXCL13/CXCR5 CX3CL1/CX3CR1. This maintaining Conclusion We summarize further research system, elaborate ways connections relevant crosstalk, potential targets, provides reference for drug development preclinical research.

Language: Английский

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Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(3), P. 1326 - 1336

Published: Feb. 3, 2023

Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients, but currently available treatments are often ineffective. Novel therapeutic targets for alleviation neuropathic urgently needed. Rhodojaponin VI, grayanotoxin from Rhododendron molle, showed remarkable antinociceptive efficacy in models pain, its biotargets mechanisms unknown. Given reversible action rhodojaponin VI narrow range over which structure can be modified, we perforwmed thermal proteome profiling rat dorsal root ganglion to determine protein target VI. N-Ethylmaleimide-sensitive fusion (NSF) was confirmed as key through biological biophysical experiments. Functional validation first time NSF facilitated trafficking Cav2.2 channel induce an increase Ca2+ current intensity, whereas reversed effects NSF. In conclusion, represents unique class analgesic natural products targeting channels via

Language: Английский

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Ginsenoside Rh2: A shining and potential natural product in the treatment of human nonmalignant and malignant diseases in the near future

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154938 - 154938

Published: June 20, 2023

Language: Английский

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Methyl Ferulic Acid Alleviates Neuropathic Pain by Inhibiting Nox4-induced Ferroptosis in Dorsal Root Ganglia Neurons in Rats

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(6), P. 3175 - 3189

Published: Feb. 22, 2023

Language: Английский

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Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of interleukin-18 levels on postherpetic neuralgia risk

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 25, 2023

Postherpetic neuralgia (PHN) is a debilitating complication of herpes zoster, characterized by persistent neuropathic pain that significantly impairs patients' quality life. Identifying factors determine PHN susceptibility crucial for its management. Interleukin-18 (IL-18), pro-inflammatory cytokine implicated in chronic pain, may play critical role development.In this study, we conducted bidirectional two-sample Mendelian randomization (MR) analyses to assess genetic relationships and potential causal associations between IL-18 protein levels increasing risk, utilizing genome-wide association study (GWAS) datasets on these traits. Two obtained from the EMBL's European Bioinformatics Institute database which contained 21,758 individuals with 13,102,515 SNPs Complete GWAS summary data 3,394 5,270,646 SNPs. The dataset FinnGen biobank had 195,191 16,380,406 SNPs.Our findings two different suggest correlation genetically predicted elevations an increased PHN.(IVW, OR 95% CI: 2.26, 1.07 4.78; p = 0.03 2.15, 1.10 4.19; =0.03, respectively), potentially indicating effect risk. However, did not detect any liability risk levels.These new insights into identifying at developing aid development novel prevention treatment approaches PHN.

Language: Английский

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