Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Language: Английский

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Multi-material additive manufacturing: A systematic review of design, properties, applications, challenges, and 3D printing of materials and cellular metamaterials

Materials & Design, Journal Year: 2023, Volume and Issue: 226, P. 111661 - 111661

Published: Jan. 27, 2023

Extensive research on nature-inspired cellular metamaterials has globally inspired innovations using single material and limited multifunctionality. Additive manufacturing (AM) of intricate geometries multi-materials provides additional functionality, environmental adaptation, improved mechanical properties. Recently, several studies have been conducted multi-material additive (MMAM) technologies, including multi-materials, methodologies, design, optimization. However, in the past six years, very few or no systematic complete reviews this domain. This review intends to comprehensively summarize MMAM systems working principles its fundamental processes. Herein, Multi-material combinations their modeling, analysis strategies reviewed systematically. In particular, focus is applications opportunities for industries postprocessing fabricated parts. Furthermore, identified limitations challenges existing software packages, processes, materials, joining mechanisms, especially at interfaces. Finally, we discuss possible overcome aforementioned technological state future directions, which will provide insights researchers engineers designing complex objects.

Language: Английский

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Highly stable flexible pressure sensors with a quasi-homogeneous composition and interlinked interfaces

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: March 10, 2022

Abstract Electronic skins (e-skins) are devices that can respond to mechanical stimuli and enable robots perceive their surroundings. A great challenge for existing e-skins is they may easily fail under extreme conditions due multilayered architecture with mismatch weak adhesion between the interlayers. Here we report a flexible pressure sensor tough interfaces enabled by two strategies: quasi-homogeneous composition ensures match of interlayers, interlinked microconed interface results in high interfacial toughness 390 J·m −2 . The endows exceptional signal stability determined performing 100,000 cycles rubbing, fixing on car tread driving 2.6 km an asphalt road. topological interlinks be further extended soft robot-sensor integration, enabling seamless robot highly stable sensing performance during manipulation tasks complicated conditions.

Language: Английский

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4D printing of shape memory polymer composites: A review on fabrication techniques, applications, and future perspectives

Journal of Manufacturing Processes, Journal Year: 2022, Volume and Issue: 81, P. 759 - 797

Published: July 25, 2022

Language: Английский

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Two‐Photon Polymerization Lithography for Optics and Photonics: Fundamentals, Materials, Technologies, and Applications

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(39)

Published: March 22, 2023

Abstract The rapid development of additive manufacturing has fueled a revolution in various research fields and industrial applications. Among the myriad advanced 3D printing techniques, two‐photon polymerization lithography (TPL) uniquely offers significant advantage nanoscale print resolution, been widely employed diverse fields, for example, life sciences, materials mechanics, microfluidics. More recently, by virtue optical transparency most resins used, TPL is finding new applications optics photonics, with nanometer to millimeter feature dimensions. It enables minimization elements systems, exploration light‐matter interactions degrees freedom, never possible before. To review recent progress related research, it starts fundamentals material formulation, then discusses novel fabrication methods, wide range These notably include diffractive, topological, quantum, color optics. With panoramic view development, concluded insights perspectives future potential

Language: Английский

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Emerging Technologies in Multi‐Material Bioprinting

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(49)

Published: Oct. 1, 2021

Bioprinting, within the emerging field of biofabrication, aims at fabrication functional biomimetic constructs. Different 3D bioprinting techniques have been adapted to bioprint cell-laden bioinks. However, single-material oftentimes fail reproduce complex compositions and diversity native tissues. Multi-material as an approach enables heterogeneous multi-cellular constructs that replicate their host microenvironments better than approaches. Here, modalities are reviewed, being multi-material is discussed, advantages challenges, encompassing both custom-designed commercially available technologies analyzed. A perspective how opens up new opportunities for tissue engineering, model therapeutics development, personalized medicine offered.

Language: Английский

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Advances in 3D/4D printing of mechanical metamaterials: From manufacturing to applications

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 254, P. 110585 - 110585

Published: Feb. 4, 2023

Language: Английский

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Recent Progress in Active Mechanical Metamaterials and Construction Principles

Advanced Science, Journal Year: 2021, Volume and Issue: 9(1)

Published: Oct. 29, 2021

Abstract Active mechanical metamaterials (AMMs) (or smart metamaterials) that combine the configurations of and active control stimuli‐responsive materials have been widely investigated in recent decades. The elaborate artificial microstructures stimulus response characteristics both contribute to AMMs, making them achieve excellent properties beyond conventional metamaterials. micro macro structures AMMs are designed based on structural construction principles such as, phase transition, strain mismatch, instability. Considering controllability efficiency materials, physical fields temperature, chemicals, light, electric current, magnetic field, pressure adopted as external stimuli practice. In this paper, frontier works latest progress from aspects mechanics reviewed. functions engineering applications also discussed. Finally, existing issues future perspectives field briefly described. This review is expected provide basis inspiration for follow‐up research AMMs.

Language: Английский

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Recent Advances in Stimuli‐Responsive Shape‐Morphing Hydrogels

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(39)

Published: July 14, 2022

Abstract Inspired by shape‐morphing organisms in nature, researchers have developed various hydrogels with stimuli‐responsive swelling, shrinking, bending, folding, origami, rolling, twisting, or locomotion. These smart are usually created patterning 4D printing. The shape morphing of allows the fabrication helixing, and rolling microstructures, all which hard to reproduce directly ordinary techniques. More importantly, under external stimuli (e.g., solvent, humidity, temperature, light, pH, electric/magnetic fields), many exhibit recoverable thus find promising applications grippers, sensors, valves, soft robotics, etc. Since determines functions a great number cases, herein, recent advances summarized, their types, mechanisms, methods, modes, extensive covered. conclusion perspectives also presented guide design functional hydrogels.

Language: Английский

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Recent advances in 3D printing of tough hydrogels: A review

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 238, P. 109895 - 109895

Published: April 13, 2022

Language: Английский

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