Artificial Intelligence‐Assisted High‐Throughput Screening of Printing Conditions of Hydrogel Architectures for Accelerated Diabetic Wound Healing DOI

Baiqi Chen,

Jianpei Dong, Marina Ruelas

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(38)

Published: July 10, 2022

Abstract In 3D (bio)printing, it is critical to optimize the printing conditions obtain scaffolds with designed structures and good uniformities. Traditional approaches for optimizing parameters oftentimes rely on prior knowledge of operators tedious optimization experiments, which can be both time‐consuming labor‐intensive. Moreover, rapid increase in types biomaterial inks geometrical complexities fabricated, such a traditional strategy may prove less effective. To address challenge, an artificial intelligence‐assisted high‐throughput printing‐condition‐screening system (AI‐HTPCSS) proposed, composed programmable pneumatic extrusion (bio)printer AI‐assisted image‐analysis algorithm. Based AI‐HTPCSS, obtaining uniformly structured hydrogel architectures are screened manner. The results show that printed under optimized demonstrate satisfying mechanical properties, vitro biological performances, efficacy accelerating diabetic wound healing vivo. unique AI‐HTPCSS expected offer enabling platform technology streamlining manufacturing tissue‐engineering through (bio)printing techniques future.

Language: Английский

Multi-material additive manufacturing: A systematic review of design, properties, applications, challenges, and 3D printing of materials and cellular metamaterials DOI Creative Commons
Aamer Nazir, Ozkan Gokcekaya, Kazi Md Masum Billah

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 226, P. 111661 - 111661

Published: Jan. 27, 2023

Extensive research on nature-inspired cellular metamaterials has globally inspired innovations using single material and limited multifunctionality. Additive manufacturing (AM) of intricate geometries multi-materials provides additional functionality, environmental adaptation, improved mechanical properties. Recently, several studies have been conducted multi-material additive (MMAM) technologies, including multi-materials, methodologies, design, optimization. However, in the past six years, very few or no systematic complete reviews this domain. This review intends to comprehensively summarize MMAM systems working principles its fundamental processes. Herein, Multi-material combinations their modeling, analysis strategies reviewed systematically. In particular, focus is applications opportunities for industries postprocessing fabricated parts. Furthermore, identified limitations challenges existing software packages, processes, materials, joining mechanisms, especially at interfaces. Finally, we discuss possible overcome aforementioned technological state future directions, which will provide insights researchers engineers designing complex objects.

Language: Английский

Citations

381
3D extrusion bioprinting DOI
Yu Shrike Zhang, Ghazaleh Haghiashtiani, Tania Hübscher

et al.

Nature Reviews Methods Primers, Journal Year: 2021, Volume and Issue: 1(1)

Published: Nov. 11, 2021

Language: Английский

Citations

223
Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review DOI Creative Commons
Ahmed Fatimi, Oseweuba Valentine Okoro, Daria Podstawczyk

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(3), P. 179 - 179

Published: March 14, 2022

Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due the increasing global demand for organ replacement and regeneration. In 3D bioprinting, which a step ahead of biomaterial printing, ink employed impregnated with cells, without compromising printability. This allows immediate scaffold cellularization generation complex structures. The use cell-laden inks or bio-inks provides opportunity enhanced cell differentiation fabrication Recognizing importance such bio-inks, current study comprehensively explores state art utilization based on natural polymers (biopolymers), as cellulose, agarose, alginate, decellularized matrix, bioprinting. Discussions regarding progress techniques approaches bioprinting polymers, limitations prospects concerning future trends human-scale are also presented.

Language: Английский

Citations

171
Advances in 3D bioprinting of tissues/organs for regenerative medicine and in-vitro models DOI
Pooja Jain, Himanshu Kathuria, Nileshkumar Dubey

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121639 - 121639

Published: June 20, 2022

Language: Английский

Citations

142
Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds DOI Creative Commons

Tejas M. Koushik,

Catherine Miller, Elsa Antunes

et al.

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(9)

Published: Dec. 13, 2022

Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, understanding bone healing pathways have opened new avenues research. The dual responsibility BTE scaffolds providing load-bearing capability interaction with local extracellular matrix to promote challenge synthetic scaffolds. This article describes usage multi-materials hierarchical structures mimic structure natural tissues function as bioactive first part this literature review physiology responses interactions at different stages repair. following section reviews available on biomaterials used followed by some multi-material approaches. next discusses impact scaffold's structural features necessity distribution scaffold structure. Finally, highlights emerging trends developments that can inspire strategies truly develop generation

Language: Английский

Citations

138
Recent advances in hyaluronic acid-based hydrogels for 3D bioprinting in tissue engineering applications DOI Creative Commons
Yanwen Ding, Xu-Wei Zhang,

Chen‐Hui Mi

et al.

Smart Materials in Medicine, Journal Year: 2022, Volume and Issue: 4, P. 59 - 68

Published: July 31, 2022

3D bioprinting technology can rapidly process cell-loaded biomaterials to prepare personalized scaffolds for repairing defective tissues, tissue regeneration, and even printing tissues or organs. relies on bioinks with appropriate rheology cytocompatibility, hydrogels are among the most promising bioink materials bioprinting. Among many hydrogel precursor materials, hyaluronic acid (HA) stands out due its excellent physicochemical biological properties, such as biocompatibility, hydrophilicity, non-immunogenicity, complete biodegradability, has become attractive bioinks. In this review, we discuss strategies adopted application of HA-based bioinks, including printability, improving their mechanical loaded cells. Finally, summarize bioprinted in various engineering applications recent years, aim provide fresh inspiration further development

Language: Английский

Citations

116
In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing DOI Creative Commons
Xiaocheng Wang, Chaoyu Yang, Yunru Yu

et al.

Research, Journal Year: 2022, Volume and Issue: 2022

Published: Jan. 1, 2022

Three-dimensional (3D) bioprinting has been extensively explored for tissue repair and regeneration, while the insufficient nutrient oxygen availability in printed constructs, as well lack of adaptive dimensions shapes, compromises overall therapeutic efficacy limits their further application. Herein, inspired by natural symbiotic relationship between salamanders algae, we present novel living photosynthetic scaffolds using an situ microfluidic-assisted 3D strategy adapting irregular-shaped wounds promoting healing. As oxygenic photosynthesis unicellular microalga (Chlorella pyrenoidosa) was incorporated during printing, generated could produce sustainable under light illumination, which facilitated cell proliferation, migration, differentiation even hypoxic conditions. Thus, when microalgae-laden were directly into diabetic wounds, they significantly accelerate chronic wound closure alleviating local hypoxia, increasing angiogenesis, extracellular matrix (ECM) synthesis. These results indicate that microalgae offers effective autotrophic biosystem healing, suggesting a promising diverse engineering applications.

Language: Английский

Citations

102
Volumetric additive manufacturing of pristine silk-based (bio)inks DOI Creative Commons
Maobin Xie, Liming Lian, Xuan Mu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 13, 2023

Volumetric additive manufacturing (VAM) enables fast photopolymerization of three-dimensional constructs by illuminating dynamically evolving light patterns in the entire build volume. However, lack bioinks suitable for VAM is a critical limitation. This study reports rapid volumetric (bio)printing pristine, unmodified silk-based (silk sericin (SS) and silk fibroin (SF)) (bio)inks to form sophisticated shapes architectures. Of interest, combined with post-fabrication processing, (bio)printed SS reveal properties including reversible as well repeated shrinkage expansion, or shape-memory; whereas SF exhibit tunable mechanical performances ranging from few hundred Pa hundreds MPa. Both types are cytocompatible. work supplies expanded bioink libraries provides path forward constructs, towards broadened biomedical applications.

Language: Английский

Citations

89
Light-based vat-polymerization bioprinting DOI
Riccardo Levato, Oksana Y. Dudaryeva, Carlos Ezio Garciamendez‐Mijares

et al.

Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)

Published: June 22, 2023

Language: Английский

Citations

76
Recent Inventions in Additive Manufacturing: Holistic Review DOI Creative Commons
Ismail Fidan,

Orkhan Huseynov,

Mohammad Alshaikh Ali

et al.

Inventions, Journal Year: 2023, Volume and Issue: 8(4), P. 103 - 103

Published: Aug. 11, 2023

This general review paper presents a condensed view of recent inventions in the Additive Manufacturing (AM) field. It outlines factors affecting development and commercialization via research collaboration discusses breakthroughs materials AM technologies their integration with emerging technologies. The explores impact across various sectors, including aerospace, automotive, healthcare, food, construction industries, since 1970s. also addresses challenges future directions, such as hybrid manufacturing bio-printing, along socio-economic environmental implications. collaborative study provides concise understanding latest AM, offering valuable insights for researchers, practitioners, decision makers diverse industries institutions.

Language: Английский

Citations

75