Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(17)
Published: Jan. 13, 2024
Abstract
Biomaterials
are
defined
as
“engineered
materials”
and
include
a
range
of
natural
synthetic
products,
designed
for
their
introduction
into
interaction
with
living
tissues.
considered
prominent
tools
in
regenerative
medicine
that
support
the
restoration
tissue
defects
retain
physiologic
functionality.
Although
commonly
used
medical
field,
these
constructs
inherently
foreign
toward
host
induce
an
immune
response
at
material–tissue
interface,
body
(FBR).
A
strong
connection
between
regeneration
is
suggested,
which
appropriate
amount
macrophage
polarization
necessary
to
trigger
autologous
formation.
Recent
developments
this
field
have
led
characterization
immunomodulatory
traits
optimizes
bioactivity,
integration
biomaterials
determines
fate
regeneration.
This
review
addresses
variety
aspects
involved
steering
inflammatory
response,
including
cell
interactions,
physical
characteristics,
biochemical
cues,
metabolomics.
Harnessing
advancing
knowledge
FBR
allows
optimization
biomaterial‐based
implants,
aiming
prevent
damage
implant,
improve
regeneration,
provide
efficient
successful
vivo
implantation.
AJP Cell Physiology,
Journal Year:
2023,
Volume and Issue:
325(4), P. C1046 - C1057
Published: Sept. 11, 2023
Pulmonary
fibrosis
results
from
a
plethora
of
abnormal
pathogenetic
events.
In
idiopathic
pulmonary
(IPF),
inhalational,
environmental,
or
occupational
exposures
in
genetically
and
epigenetically
predisposed
individuals
trigger
recurrent
cycles
alveolar
epithelial
cell
injury,
activation
coagulation
pathways,
chemoattraction,
differentiation
monocytes
into
monocyte-derived
macrophages
(Mo-AMs).
When
these
events
happen
intermittently
repeatedly
throughout
the
individual's
life
cycle,
wound
repair
process
becomes
aberrant
leading
to
bronchiolization
distal
air
spaces,
fibroblast
accumulation,
extracellular
matrix
deposition,
loss
alveolar-capillary
architecture.
The
role
immune
dysregulation
IPF
pathogenesis
progression
has
been
underscored
past
mainly
after
disappointing
immunosuppressant
use
patients;
however,
recent
reports
highlighting
prognostic
mechanistic
roles
Mo-AMs
revived
interest
IPF.
this
review,
we
will
discuss
cells
onset
IPF,
as
well
potential
targeted
therapies.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(13), P. 3468 - 3468
Published: July 2, 2023
Various
cancer
cell-associated
intrinsic
and
extrinsic
inputs
act
on
YAP/TAZ
proteins
to
mediate
the
hyperactivation
of
TEAD
transcription
factor-based
transcriptome.
This
YAP/TAZ-TEAD
activity
can
override
growth-limiting
Hippo
tumor-suppressor
pathway
that
maintains
normal
tissue
homeostasis.
Herein,
we
provide
an
integrated
summary
contrasting
roles
during
homeostasis
versus
tumor
initiation
progression.
In
addition
upstream
factors
regulate
in
TME,
critical
insights
emerging
functions
immune
suppression
abnormal
vasculature
development
tumorigenesis
are
illustrated.
Lastly,
discuss
current
methods
intervene
with
oncogenic
signaling
applications
combination
therapies,
gut
microbiota,
epigenetic
plasticity
could
potentiate
efficacy
chemo/immunotherapy
as
improved
therapeutic
strategies.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(5)
Published: Dec. 3, 2023
Abstract
The
interplay
between
immune
cells/macrophages
and
fibroblast‐like
synoviocytes
(FLSs)
plays
a
pivotal
role
in
initiating
synovitis;
however,
their
involvement
metabolic
disorders,
including
diabetic
osteoarthritis
(DOA),
is
largely
unknown.
In
this
study,
single‐cell
RNA
sequencing
(scRNA‐seq)
employed
to
investigate
the
synovial
cell
composition
of
DOA.
A
significant
enrichment
activated
macrophages
within
eight
distinct
clusters
found
DOA
synovium.
Moreover,
it
demonstrated
that
increased
glycolysis
FLSs
key
driver
for
patients’
macrophage
infiltration
polarization.
addition,
yes‐associated
protein
1
(YAP1)/thioredoxin‐interacting
(TXNIP)
signaling
axis
play
crucial
regulating
glucose
transporter
(GLUT1)‐dependent
FLSs,
thereby
controlling
expression
series
adhesion
molecules
such
as
intercellular
molecule‐1
(ICAM‐1)
which
may
subsequently
fine‐tune
M1‐polarized
patients
db/db
OA
mice.
For
treatment,
M1
membrane‐camouflaged
Verteporfin
(Vt)‐loaded
PLGA
nanoparticles
(MVPs)
are
developed
ameliorate
progression
by
YAP1/TXNIP
axis,
thus
suppressing
macrophages.
results
provide
several
novel
insights
into
pathogenesis
offer
promising
treatment
approach
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(17)
Published: Jan. 13, 2024
Abstract
Biomaterials
are
defined
as
“engineered
materials”
and
include
a
range
of
natural
synthetic
products,
designed
for
their
introduction
into
interaction
with
living
tissues.
considered
prominent
tools
in
regenerative
medicine
that
support
the
restoration
tissue
defects
retain
physiologic
functionality.
Although
commonly
used
medical
field,
these
constructs
inherently
foreign
toward
host
induce
an
immune
response
at
material–tissue
interface,
body
(FBR).
A
strong
connection
between
regeneration
is
suggested,
which
appropriate
amount
macrophage
polarization
necessary
to
trigger
autologous
formation.
Recent
developments
this
field
have
led
characterization
immunomodulatory
traits
optimizes
bioactivity,
integration
biomaterials
determines
fate
regeneration.
This
review
addresses
variety
aspects
involved
steering
inflammatory
response,
including
cell
interactions,
physical
characteristics,
biochemical
cues,
metabolomics.
Harnessing
advancing
knowledge
FBR
allows
optimization
biomaterial‐based
implants,
aiming
prevent
damage
implant,
improve
regeneration,
provide
efficient
successful
vivo
implantation.
