Advances in human intracranial electroencephalography research, guidelines and good practices

NeuroImage, Journal Year: 2022, Volume and Issue: 260, P. 119438 - 119438

Published: July 2, 2022

Since the second half of twentieth century, intracranial electroencephalography (iEEG), including both electrocorticography (ECoG) and stereo-electroencephalography (sEEG), has provided an intimate view into human brain. At interface between fundamental research clinic, iEEG provides high temporal resolution spatial specificity but comes with constraints, such as individual's tailored sparsity electrode sampling. Over years, researchers in neuroscience developed their practices to make most approach. Here we offer a critical review didactic framework for newcomers, well addressing issues encountered by proficient researchers. The scope is threefold: (i) common research, (ii) suggest potential guidelines working data answer frequently asked questions based on widespread practices, (iii) current neurophysiological knowledge methodologies, pave way good practice standards research. organization this paper follows steps processing. first section contextualizes collection. focuses localization electrodes. third highlights main pre-processing steps. fourth presents signal analysis methods. fifth discusses statistical approaches. sixth draws some unique perspectives Finally, ensure consistent nomenclature throughout manuscript align other guidelines, e.g., Brain Imaging Data Structure (BIDS) OHBM Committee Best Practices Analysis Sharing (COBIDAS), provide glossary disambiguate terms related

Language: Английский

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Frequency-specific and state-dependent neural responses to brain stimulation

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 17, 2023

Traumatic events result in vivid and enduring fear memories. Suppressing the retrieval of these memories is central to behavioral therapies for pathological fear. The medial prefrontal cortex (mPFC) hippocampus (HPC) have been implicated suppression, but how mPFC-HPC activity coordinated during extinction unclear. Here we show that after training, coherent theta oscillations (6-9 Hz) HPC mPFC are correlated with suppression conditioned freezing male female rats. Inactivation nucleus reuniens (RE), a thalamic hub interconnecting HPC, reduces extinction-related Fos expression both dampens coherence, impairs retrieval. Conversely, theta-paced optogenetic stimulation RE augments relapse extinguished Collectively, results demonstrate role coordinating interactions suppress extinction.

Language: Английский

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Anxiety and depression: A top‐down, bottom‐up model of circuit function

Annals of the New York Academy of Sciences, Journal Year: 2023, Volume and Issue: 1525(1), P. 70 - 87

Published: May 2, 2023

Abstract A functional interplay of bottom‐up and top‐down processing allows an individual to appropriately respond the dynamic environment around them. These modalities can be represented as attractor states using a dynamical systems model brain. The transition probability move from one state another is dependent on stability, depth, neuromodulatory tone, tonic changes in plasticity. However, how does relationship between these change disease states, such anxiety or depression? We describe Marr's computational‐algorithmic‐implementation perspective understand depressive anxious states. illustrate examples basolateral amygdala signaling projections medial prefrontal cortex internal projections. Understanding dynamics help us better multifaceted elements depression.

Language: Английский

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A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 24, 2023

Abstract The neurophysiological mechanisms in the human amygdala that underlie post-traumatic stress disorder (PTSD) remain poorly understood. In a first-of-its-kind pilot study, we recorded intracranial electroencephalographic data longitudinally (over one year) two male individuals with electrodes implanted for management of treatment-resistant PTSD (TR-PTSD) under clinical trial NCT04152993. To determine electrophysiological signatures related to emotionally aversive and clinically relevant states (trial primary endpoint), characterized neural activity during unpleasant portions three separate paradigms (negative emotional image viewing, listening recordings participant-specific trauma-related memories, at-home-periods symptom exacerbation). We found selective increases theta (5–9 Hz) bandpower across all negative experiences. Subsequent use elevations low-frequency as trigger closed-loop neuromodulation led significant reductions TR-PTSD symptoms secondary endpoint) following year treatment well aversive-related activity. Altogether, our findings provide early evidence elevated range negative-related behavioral may be promising target future therapies PTSD.

Language: Английский

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Neuromodulation of Neural Oscillations in Health and Disease

Biology, Journal Year: 2023, Volume and Issue: 12(3), P. 371 - 371

Published: Feb. 26, 2023

Using EEG and local field potentials (LFPs) as an index of large-scale neural activities, research has been able to associate oscillations in different frequency bands with markers cognitive functions, goal-directed behavior, various neurological disorders. While this gives us a glimpse into how neurons communicate throughout the brain, causality these synchronized network activities remains poorly understood. Moreover, effect major neuromodulatory systems (e.g., noradrenergic, cholinergic, dopaminergic) on brain drawn much attention. More recent studies have suggested that cross-frequency coupling (CFC) is heavily responsible for mediating network-wide communication across subcortical cortical structures, implicating importance neurotransmitters shaping coordinated actions. By bringing light role each system plays regulating brain-wide oscillations, we hope paint clearer picture pivotal play variety functions disorders, neuromodulation techniques can be optimized means controlling dynamics. The aim review showcase important dynamics, informing future pay close attention their involvement specific features associated behaviors.

Language: Английский

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Synchronized LFP rhythmicity in the social brain reflects the context of social encounters

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Jan. 2, 2024

Abstract Mammalian social behavior is highly context-sensitive. Yet, little known about the mechanisms that modulate according to its context. Recent studies have revealed a network of mostly limbic brain regions which regulates behavior. We hypothesize coherent theta and gamma rhythms reflect organization this into functional sub-networks in context-dependent manner. To test concept, we simultaneously record local field potential (LFP) from multiple adult male mice performing three discrimination tasks. While LFP rhythmicity across all tasks dominated by global internal state, pattern coherence between various behavioral task more than other variables. Moreover, Granger causality analysis implicate ventral dentate gyrus as main player coordinating context-specific rhythmic activity. Thus, our results suggest coordinated activity within reflects subject’s

Language: Английский

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Acetylcholine engages distinct amygdala microcircuits to gate internal theta rhythm

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. e1568232024 - e1568232024

Published: March 4, 2024

Acetylcholine (ACh) is released from basal forebrain cholinergic neurons in response to salient stimuli and engages brain states supporting attention memory. These high ACh are associated with theta oscillations, which synchronize neuronal ensembles. Theta oscillations basolateral amygdala (BLA) both humans rodents have been shown underlie emotional memory, yet their mechanism remains unclear. Here, using slice electrophysiology male female mice, we show large evoke prolonged BLA local field potentials that depend upon M3 muscarinic receptor activation of cholecystokinin (CCK) interneurons (INs) without the need for external glutamate signaling. Somatostatin (SOM) INs inhibit CCK themselves inhibited by ACh, providing a functional SOM-CCK IN circuit connection gating theta. Parvalbumin (PV) INs, can drive baseline states, not involved generation ACh-induced theta, highlighting induces cellular switch control oscillatory activity establishes an internally BLA-driven oscillation through INs. more readily evoked over cortex or hippocampus, suggesting preferential during states. data reveal gates internal suggest acting into network state enabling Significance statement While plays critical role establishing behaviors, mechanisms acts on circuits processes remain The receives dense projections key behaviors. Using recordings mouse slices, induce CCK, but PV gated SOM CCK-SOM microcircuit oscillations. Further, induced compared hippocampus cortex. results detailed circuit-specific modulation play processing.

Language: Английский

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Neuronal theta oscillation of hippocampal ensemble and memory function

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: 481, P. 115429 - 115429

Published: Jan. 10, 2025

Language: Английский

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The case for hemispheric lateralization of the human amygdala in fear processing

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The amygdala has increasingly been proposed as a therapeutic target for patients with post-traumatic stress disorder (PTSD). However, the distinct contributions of left and right to various aspects fear processing remain inadequately understood. Here, we critically re-evaluate key findings from human functional neuroimaging lesion studies on conditioning extinction. We propose that while both amygdalae likely make critical processing, is more associated sensory-mediated expression, cognitive-mediated acquisition With accumulating evidence studies, suggest differentially targeting versus ablative or neuromodulatory therapies can be crucial optimizing PTSD treatment.

Language: Английский

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