Basolateral amygdala oscillations enable fear learning in a biophysical model DOI Open Access
Anna Cattani, Don B. Arnold, Michelle M. McCarthy

et al.

Published: Nov. 4, 2024

The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (∼3-6 Hz), high (∼6-12 and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it not understood what role these play supporting Here, we create biophysically detailed model of circuit to show that several classes interneurons (PV, SOM, VIP) can be critically involved producing rhythms; promote formation dedicated shaped spike-timing-dependent Each class necessary for We find rhythm biomarker successful conditioning. makes use commonly found cortex and, hence, may apply wide variety associative situations.

Language: Английский

Basal forebrain innervation of the amygdala: an anatomical and computational exploration DOI Creative Commons
Tuğçe Tuna, Tyler Banks, Gregory Glickert

et al.

Brain Structure and Function, Journal Year: 2025, Volume and Issue: 230(1)

Published: Jan. 13, 2025

Abstract Theta oscillations of the mammalian amygdala are associated with processing, encoding and retrieval aversive memories. In hippocampus, power network theta oscillation is modulated by basal forebrain (BF) GABAergic projections. Here, we combine anatomical computational approaches to investigate if similar BF projections amygdaloid complex provide an analogous modulation local activity. We used retrograde tracing fluorescent immunohistochemistry identify cholinergic non-cholinergic parvalbumin- or calbindin-immunoreactive neuronal subgroups targeting input (lateral basolateral nuclei) output (central nucleus central bed stria terminalis) regions complex. observed a dense non-cholinergic, putative projection from ventral pallidum (VP) substantia innominata (SI) (BLA). The VP/SI axonal BLA were confirmed using viral anterograde transsynaptic labeling. tested potential function this VP/SI-BLA pathway in 1000-cell biophysically realistic model, which incorporated principal neurons three major interneuron groups BLA, together extrinsic glutamatergic, cholinergic, inputs. silico that theta-modulation enhanced via their selective innervation parvalbumin-expressing interneurons. Ablation parvalbumin-, but not somatostatin- calretinin-expressing, interneurons reduced model. These results suggest long-range may modulate activity at target through formation common interneuron-type oscillatory phase-specific disinhibitory motif.

Language: Английский

Citations

1
Basolateral amygdala parvalbumin and cholecystokinin-expressing GABAergic neurons modulate depressive and anxiety-like behaviors DOI Creative Commons
Muhammad Asim, Huajie Wang, Abdul Waris

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 5, 2024

Language: Английский

Citations

5
Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety DOI Creative Commons
Xin Fu, Jeffrey G. Tasker

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: June 27, 2024

The basolateral amygdala plays pivotal roles in the regulation of fear and anxiety these processes are profoundly modulated by different neuromodulatory systems that recruited during emotional arousal. Recent studies suggest activities BLA interneurons inhibitory synaptic transmission principal cells regulated neuromodulators to influence output oscillatory network states BLA, ultimately behavioral expression anxiety. In this review, we first summarize a cellular mechanism stress-induced anxiogenesis mediated interaction glucocorticoid endocannabinoid signaling at synapses BLA. Then discuss cell type-specific activity patterns induced converging on Gq pathway perisomatic parvalbumin-expressing (PV) cholecystokinin-expressing (CCK) basket their effects oscillations learning.

Language: Английский

Citations

3
Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations DOI Creative Commons
Alexander J. McDonald

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(3)

Published: March 1, 2024

Abstract The projections of the basal forebrain (BF) to hippocampus and neocortex have been extensively studied shown be important for higher cognitive functions, including attention, learning, memory. Much less is known about BF basolateral nuclear complex amygdala (BNC), although cholinergic innervation this region by actually far more robust than that cortical areas. This review will focus on light electron microscopic tract‐tracing immunohistochemical (IHC) studies, many which were published in last decade, analyzed relationship inputs their receptors specific neuronal subtypes BNC order better understand anatomical substrates BF‐BNC circuitry. results indicate mainly target nucleus (BL) arise from cholinergic, GABAergic, perhaps glutamatergic neurons. Cholinergic dendrites spines pyramidal neurons (PNs) express muscarinic (MRs). MRs are also expressed axons, as well thalamic axons synapse with PN spines. GABAergic BL interneurons contain parvalbumin. It suggested BF‐BL circuitry could very generating rhythmic oscillations critical emotional learning. might contribute memory formation activating M1 located dendritic shafts NMDA receptors.

Language: Английский

Citations

1
Basolateral amygdala oscillations enable fear learning in a biophysical model DOI Creative Commons
Anna Cattani, Don B. Arnold, Michelle M. McCarthy

et al.

eLife, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 26, 2024

The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (~3–6 Hz), high (~6–12 and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it not understood what role these play supporting Here, we create biophysically detailed model of circuit to show that several classes interneurons (PV, SOM, VIP) can be critically involved producing rhythms; promote formation dedicated shaped spike-timing-dependent Each class necessary for We find rhythm biomarker successful conditioning. makes use commonly found cortex and, hence, may apply wide variety associative situations.

Language: Английский

Citations

1
Basolateral amygdala oscillations enable fear learning in a biophysical model DOI Creative Commons
Anna Cattani, Don B. Arnold, Michelle M. McCarthy

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Aug. 14, 2023

The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (~3–6 Hz), high (~6–12 and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it not understood what role these play supporting Here, we create biophysically detailed model of circuit to show that several classes interneurons (PV, SOM, VIP) can be critically involved producing rhythms; promote formation dedicated shaped spike-timing-dependent Each class necessary for We find rhythm biomarker successful conditioning. makes use commonly found cortex and, hence, may apply wide variety associative situations.

Language: Английский

Citations

2
Basolateral amygdala oscillations enable fear learning in a biophysical model DOI Creative Commons
Anna Cattani, Don B. Arnold, Michelle M. McCarthy

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 28, 2023

Abstract The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (∼3-6 Hz), high (∼6-12 and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it not understood what role these play supporting Here, we create biophysically detailed model of circuit to show that several classes interneurons (PV, SOM, VIP) can be critically involved producing rhythms; promote formation dedicated shaped spike-timing-dependent Each class necessary for We find rhythm biomarker successful conditioning. makes use commonly found cortex and, hence, may apply wide variety associative situations. Significance Our paper accounts experimental evidence showing amygdalar exist, suggests network origins rhythms, points their central mechanisms plasticity learning. It one few papers address high-order cognition with models, which are sometimes thought too adequately constrained. provides template how information about brain constrain biophysical models. detail, first time, multiple help provide time scales some kinds (STDP). spells out conditions under such interactions between needed STDP why. Finally, our work helps framework by discrepancies literature might reevaluated. In particular, discuss issues Hebbian learning; context neuromodulation resolve those issues. addresses more general than since based on cortex, as well amygdala.

Language: Английский

Citations

1
Scopolamine infusion in the basolateral amygdala after saccharin intake induces conditioned taste avoidance in rats DOI Creative Commons
Víctor Manuel Torres-García,

Emmanuel Rodríguez-Nava,

Rosa Itzel Alcántara-Rivas

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(10), P. 2133 - 2144

Published: June 1, 2024

Abstract Rationale Muscarinic receptor activity in the basolateral amygdala (BLA) is known to be involved plasticity mechanisms that underlie emotional learning. The BLA Attenuation of Neophobia, an incidental taste learning task which a novel becomes familiar and recognized as safe. Objective Here we assessed role muscarinic Methods Young adult male Wistar rats were bilaterally implanted with cannulas aimed at BLA. After recovery, randomly assigned either vehicle or antagonist group, for each experiment. We tested effect specific non-specific antagonists administered 1) 20 min before presentation; 2) immediately after 3) retrieval (the second presentation on Day 5 -S2-) fifth 8 (S5). Results Non-specific scopolamine infused prior taste, while not affecting preference, abolished AN, i.e., increased preference observed control animals presentation. When consumption, intra-BLA only prevented AN but caused steep decrease This scopolamine-induced avoidance was dependent novelty, nor did it generalize another taste. Targeting putative postsynaptic receptors M1 M3 appeared produce partial avoidance, M2 antagonism had no effect. Conclusion These data suggest if salient gustatory experience followed by BLA, will strongly persistently avoided future. study also shows just amnesic drug, its cognitive effects may highly structure involved.

Language: Английский

Citations

0
Basolateral amygdala oscillations enable fear learning in a biophysical model DOI Open Access
Anna Cattani, Don B. Arnold, Michelle M. McCarthy

et al.

Published: Nov. 4, 2024

The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (∼3-6 Hz), high (∼6-12 and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it not understood what role these play supporting Here, we create biophysically detailed model of circuit to show that several classes interneurons (PV, SOM, VIP) can be critically involved producing rhythms; promote formation dedicated shaped spike-timing-dependent Each class necessary for We find rhythm biomarker successful conditioning. makes use commonly found cortex and, hence, may apply wide variety associative situations.

Language: Английский

Citations

0