First Organoid Intelligence (OI) workshop to form an OI community DOI Creative Commons
Itzy E. Morales Pantoja, Lena Smirnova,

Alysson R. Muotri

et al.

Frontiers in Artificial Intelligence, Journal Year: 2023, Volume and Issue: 6

Published: Feb. 28, 2023

The brain is arguably the most powerful computation system known. It extremely efficient in processing large amounts of information and can discern signals from noise, adapt, filter faulty all while running on only 20 watts power. human brain's efficiency, progressive learning, plasticity are unmatched by any computer system. Recent advances stem cell technology have elevated field culture to higher levels complexity, such as development three-dimensional (3D) organoids that recapitulate functionality better than traditional monolayer systems. Organoid Intelligence (OI) aims harness innate biological capabilities for biocomputing synthetic intelligence interfacing them with technology. With latest strides technology, bioengineering, machine we explore ability compute, store given (input), execute a task (output), study how this affects structural functional connections themselves. Furthermore, understanding learning generates changes patterns connectivity shed light early stages cognition brain. Investigating these concepts an enormous, multidisciplinary endeavor necessitates engagement both scientific community public. Thus, Feb 22–24 2022, Johns Hopkins University held first Workshop form OI Community lay out groundwork establishment new discipline. potential revolutionize computing, neurological research, drug was discussed, along vision roadmap its over coming decade.

Language: Английский

Mechanically-Guided 3D Assembly for Architected Flexible Electronics DOI Creative Commons
Renheng Bo, Shiwei Xu,

Youzhou Yang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 11137 - 11189

Published: Sept. 7, 2023

Architected flexible electronic devices with rationally designed 3D geometries have found essential applications in biology, medicine, therapeutics, sensing/imaging, energy, robotics, and daily healthcare. Mechanically-guided assembly methods, exploiting mechanics principles of materials structures to transform planar fabricated using mature semiconductor techniques into architected ones, are promising routes such devices. Here, we comprehensively review mechanically-guided methods for electronics. Mainstream classified discussed on the basis their fundamental deformation modes (i.e., rolling, folding, curving, buckling). Diverse interconnects device forms then summarized, which correspond two key components an device. Afterward, structure-induced functionalities highlighted provide guidelines function-driven structural designs electronics, followed by a collective summary resulting applications. Finally, conclusions outlooks given, covering achieve extreme deformations dimensions, inverse design encapsulation strategies as well perspectives future

Language: Английский

Citations

66
Low-dimensional nanostructures for monolithic 3D-integrated flexible and stretchable electronics DOI
Qilin Hua, Guozhen Shen

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(3), P. 1316 - 1353

Published: Jan. 1, 2024

Low-dimensional nanostructures, with their small size, unique characteristics, flexible/elastic adaptability, and effective vertical stacking capability, play a crucial role in advancing monolithic 3D-integrated flexible/stretchable systems.

Language: Английский

Citations

61
Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids DOI
Xiao Yang, Csaba Forró, Thomas L. Li

et al.

Nature Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 22, 2024

Language: Английский

Citations

50
Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity DOI Creative Commons
Mengge Wu, Kuanming Yao,

Ningge Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(14)

Published: Feb. 24, 2023

Abstract A critical challenge lies in the development of next‐generation neural interface, mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft multichannel interface is presented based on organic‐electrochemical‐transistor‐(OECT)‐based network, with capabilities continuous high‐fidelity mapping signals biosafety active degrading performing functions. Such platform yields a high spatiotemporal resolution 1.42 ms 20 µm, signal‐to‐noise ratio up to ≈37 dB. The implantable OECT arrays can well establish functional interfaces, designed as fully biodegradable electronic platforms vivo. Demonstrated applications such implants include real‐time monitoring electrical activities from cortical surface rats under various conditions (e.g., narcosis, epileptic seizure, electric stimuli) electrocorticography 100 channels. This technology offers general applicability great potential utility treatment/diagnosis neurological disorders.

Language: Английский

Citations

45
Bionic octopus-like flexible three-dimensional force sensor for meticulous handwriting recognition in human-computer interactions DOI

Diqing Ruan,

Guanzheng Chen,

Xuanzi Luo

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 123, P. 109357 - 109357

Published: Feb. 8, 2024

Language: Английский

Citations

27
Soft, full Wheatstone bridge 3D pressure sensors for cardiovascular monitoring DOI Creative Commons
Yoonseok Park, Haiwen Luan, Kyeongha Kwon

et al.

npj Flexible Electronics, Journal Year: 2024, Volume and Issue: 8(1)

Published: Jan. 29, 2024

Abstract Variations in parameters associated with the ambient environment can introduce noise soft, body-worn sensors. For example, many piezoresistive pressure sensors exhibit a high degree of sensitivity to fluctuations temperature, thereby requiring active compensation strategies. The research presented here addresses this challenge multilayered 3D microsystem design that integrates four full-Wheatstone bridge configuration. An optimized layout relative neutral mechanical plane leads both an insensitivity temperature and increased pressure, previously reported devices rely on similar operating principles. Integrating sensor into flexible electronics platform yields system capable real-time, wireless measurements from surface skin. Placement above radial carotid arteries high-quality waveforms pulsatile blood flow, quantitative correlations pressure. results establish materials engineering aspects technology broad potential remote health monitoring.

Language: Английский

Citations

26
Bio‐Inspired Dynamically Morphing Microelectronics toward High‐Density Energy Applications and Intelligent Biomedical Implants DOI Creative Commons
Leandro Merces,

Letícia M. M. Ferro,

A. Thomas

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: Feb. 25, 2024

Choreographing the adaptive shapes of patterned surfaces to exhibit designable mechanical interactions with their environment remains an intricate challenge. Here, a novel category strain-engineered dynamic-shape materials, empowering diverse multi-dimensional shape modulations that are combined form fine-grained microarchitectures is introduced. Using micro-origami tessellation technology, heterogeneous materials provided strategic creases featuring stimuli-responsive micro-hinges morph precisely upon chemical and electrical cues. Freestanding multifaceted foldable packages, auxetic mesosurfaces, morphable cages three forms demonstrated herein these complex 4-dimensional (4D) metamaterials. These systems integrated in dual proof-of-concept bioelectronic demonstrations: soft supercapacitor enhancing its power density (≈108 mW cm

Language: Английский

Citations

17
In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium DOI Creative Commons
Young‐Geun Park, Yong Won Kwon, Chin Su Koh

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 27, 2024

Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which deteriorate the integrity of device biological systems and restrict free behavior subject. We report soft, conformable interface system that can monitor single-unit activities neurons with long-term stability. The implements in brain, their subsidiary directly printed on cranial surface. high-resolution printing liquid metals forms cellular-scale diameter adaptable lengths. Also, metal-based circuits interconnections along curvature cranium enables conformal integration circuit delivers signals smartphone wirelessly. In in-vivo studies using mice, demonstrates recording (33 weeks) arbitrary brain regions. T-maze behavioral tests, shows behavior-induced activation multiple

Language: Английский

Citations

17
A patient-specific lung cancer assembloid model with heterogeneous tumor microenvironments DOI Creative Commons
Yanmei Zhang, Qifan Hu,

Yuquan Pei

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 20, 2024

Abstract Cancer models play critical roles in basic cancer research and precision medicine. However, current vitro are limited by their inability to mimic the three-dimensional architecture heterogeneous tumor microenvironments (TME) of vivo tumors. Here, we develop an innovative patient-specific lung assembloid (LCA) model using droplet microfluidic technology based on a microinjection strategy. This method enables precise manipulation clinical microsamples rapid generation LCAs with good intra-batch consistency size cell composition evenly encapsulating patient tumor-derived TME cells organoids inside microgels. recapitulate inter- intratumoral heterogeneity, cellular diversity, genomic transcriptomic landscape parental LCA could reconstruct functional heterogeneity cancer-associated fibroblasts reflect influence drug responses compared organoids. Notably, accurately replicate outcomes patients, suggesting potential predict personalized treatments. Collectively, our studies provide valuable for precisely fabricating assembloids promising

Language: Английский

Citations

17
Highly stretchable and customizable microneedle electrode arrays for intramuscular electromyography DOI Creative Commons
Qinai Zhao, Ekaterina Gribkova, Yiyang Shen

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(18)

Published: May 1, 2024

Stretchable three-dimensional (3D) penetrating microelectrode arrays have potential utility in various fields, including neuroscience, tissue engineering, and wearable bioelectronics. These 3D can penetrate conform to dynamically deforming tissues, thereby facilitating targeted sensing stimulation of interior regions a minimally invasive manner. However, fabricating custom stretchable presents material integration patterning challenges. In this study, we present the design, fabrication, applications microneedle electrode (SMNEAs) for local intramuscular electromyography signals ex vivo. We use unique hybrid fabrication scheme based on laser micromachining, microfabrication, transfer printing enable scalable individually addressable SMNEA with high device stretchability (60 90%). The geometries recording regions, impedance, array layout, length distribution are highly customizable. demonstrate SMNEAs as bioelectronic interfaces from muscle groups buccal mass

Language: Английский

Citations

17