Vision Research, Journal Year: 2023, Volume and Issue: 208, P. 108224 - 108224
Published: April 1, 2023
Language: Английский
Current Biology, Journal Year: 2023, Volume and Issue: 33(15), P. 3179 - 3191.e4
Published: July 11, 2023
Language: Английский
Citations
15
Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 57, P. 101391 - 101391
Published: April 17, 2024
Animal brains are probably the most complex computational machines on our planet, and like everything in biology, they product of evolution. Advances developmental palaeobiology have been expanding general understanding how nervous systems can change at a molecular structural level. However, these changes translate into altered function — that is, 'computation' remains comparatively sparsely explored. What, concretely, does it mean for neuronal computation when neurons their morphology connectivity, new appear or old ones disappear, transmitter slowly modified over many generations? And evolution use possible knobs dials to constantly tune give rise amazing diversity animal behaviours we see today? Addressing major gaps benefits from choosing suitable model system. Here, I present vertebrate retina as one perhaps unusually promising candidate. The is ancient displays highly conserved core organisational principles across entire lineage, alongside myriad adjustments extant species were shaped by history visual ecology. Moreover, logic readily interrogated experimentally, existing retinal circuits handful serve an anchor exploring circuit adaptations tree life, fish deep aphotic zone oceans eagles soaring high up sky.
Language: Английский
Citations
5
Cell Reports, Journal Year: 2023, Volume and Issue: 42(2), P. 112055 - 112055
Published: Feb. 1, 2023
The vertebrate inner retina is driven by photoreceptors whose outputs are already pre-processed; in zebrafish, outer retinal circuits split "color" from "grayscale" information across four cone-photoreceptor types. It remains unclear how the processes incoming spectral while also combining cone signals to shape grayscale functions. We address this question imaging light-driven responses of amacrine cells (ACs) and bipolar (BCs) larval zebrafish presence pharmacological absence inhibition. find that ACs enhance opponency some at same time suppressing pre-existing others, so that, depending on region, net change number color-opponent units essentially zero. To achieve "dynamic balance," counteract intrinsic color BCs via On channel. Consistent with these observations, Off-stratifying exclusively achromatic, all stratify sublamina.
Language: Английский
Citations
12
Developmental Cell, Journal Year: 2024, Volume and Issue: 59(16), P. 2158 - 2170.e6
Published: Aug. 1, 2024
Unlike humans, teleosts like zebrafish exhibit robust retinal regeneration after injury from endogenous stem cells. However, it is unclear if regenerating cone photoreceptors regain physiological function and integrate correctly into post-synaptic circuits. We used two-photon calcium imaging of living adult retina to examine photoreceptor responses before light-induced lesions. To assess functional recovery cones downstream outer circuits, we exploited color opponency; UV intrinsic Off-response blue light, but On-response green which depends on feedback signals Accordingly, assessed the presence quality Off- vs. On-responses found that regenerated both Off-responses short-wavelength long-wavelength light within 3 months lesion. Therefore, circuit functionality restored in photoreceptors, suggesting inducing a promising strategy for human repair.
Language: Английский
Citations
4
Science Advances, Journal Year: 2021, Volume and Issue: 7(41)
Published: Oct. 8, 2021
A transcriptional regulator Foxq2 controls blue-type cone opsin gene in vertebrate species having tetrachromatic visual system.
Language: Английский
Citations
27
PLoS Biology, Journal Year: 2025, Volume and Issue: 23(5), P. e3003157 - e3003157
Published: May 7, 2025
Vertebrate photoreceptors have been studied for well over a century, but fixed nomenclature referring to orthologous cell types across diverse species has lacking. Instead, variably—and often confusingly—named according morphology, presence/absence of ‘rhodopsin’, spectral sensitivity, chromophore usage, and/or the gene family opsin(s) they express. Here, we propose unified vertebrate rods and cones that aligns with naming systems other retinal classes is based on photoreceptor type’s putative evolutionary history. This classification informed by functional, anatomical, developmental, molecular identities neuron as whole, including expression deeply conserved transcription factors required development. The proposed names will be applicable all vertebrates indicative widest possible range properties, their postsynaptic wiring, hence allude common species-specific roles in vision. Furthermore, system open-ended accommodate future discovery as-yet unknown types.
Language: Английский
Citations
0
Annual Review of Vision Science, Journal Year: 2022, Volume and Issue: 8(1), P. 171 - 193
Published: June 9, 2022
An ultimate goal in retina science is to understand how the neural circuit of processes natural visual scenes. Yet most studies laboratories have long been performed with simple, artificial stimuli such as full-field illumination, spots light, or gratings. The underlying assumption that features thus identified carry over more complex scenario As application corresponding settings becoming commonplace experimental investigations, this being put test and opportunities arise discover processing are triggered by specific aspects Here, we review used probe, refine, complement knowledge accumulated under simplified stimuli, discuss challenges along way toward a comprehensive understanding encoding
Language: Английский
Citations
15
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 13, 2023
ABSTRACT Vertebrates rely on rod photoreceptors for vision in low-light conditions 1 . Mammals have a specialized downstream circuit signaling called the primary pathway, which comprises specific cell types and wiring patterns that are thought to be unique this lineage 2–6 Thus, it has been long assumed pathway evolved mammals 3, 5–7 Here, we challenge view by demonstrating mammalian is conserved zebrafish, diverged from extant ∼400 million years ago. Using single-cell RNA-sequencing, identified two bipolar (BC) zebrafish related BCs (RBCs) of pathway. By combining electrophysiology, histology, ultrastructural reconstruction RBCs, found that, like RBCs 8 , both RBC connect with all rods red-cones their dendritic territory, provide output largely onto amacrine cells. The pattern cells post-synaptic one type strikingly similar RBCs. This suggests design may emerged before divergence teleost fish amniotes (mammals, bird, reptiles). second forms separate pathways first type, either lost or serve yet unknown roles. Highlights - Zebrafish (RBC1/2). Synaptic connectivity RBC1 resembles therefore probably more than 400 RBC2, RBC1.
Language: Английский
Citations
9
Current Biology, Journal Year: 2021, Volume and Issue: 31(23), P. 5214 - 5226.e4
Published: Oct. 16, 2021
Retinal bipolar cells integrate cone signals at dendritic and axonal sites. The route, involving amacrine cells, remains largely uncharted. However, because types differ in their spectral sensitivities, insights into cells' integration might be gained based on tunings. We therefore recorded vivo responses of cell presynaptic terminals larval zebrafish to widefield but spectrally resolved flashes light mapped the results onto four cones. This "spectral circuit mapping" allowed explaining ∼95% temporal variance a simple linear model, thereby revealing several notable rules inner retina. Bipolar were dominated by red-cone inputs, often alongside equal sign inputs from blue green In contrast, UV-cone uncorrelated with those remaining led new axis opponency where red-, green-, blue-cone "Off" circuits connect "natively-On" outermost fraction plexiform layer—much as how key color opponent are established mammals. Beyond this, despite substantial diversity that was not present cones, tunings surprisingly simple. They either approximately resembled both non-opponent motifs already cones or exhibited stereotyped broadband response. this way, only preserved efficient representations also diversified them set up total six dominant motifs, which included three axes opponency.
Language: Английский
Citations
16
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 5, 2024
SUMMARY Vision begins when photoreceptors convert light fluctuations into temporal patterns of glutamate release that drive the retinal network. The input-output relation at this first stage has not been systematically measured in vivo so it is known how operates across a photoreceptor population. Using kHz-rate imaging zebrafish, we find individual red cones encode visual stimuli with high reliability and time-precision, but routinely vary sensitivity to luminance, contrast, frequency Variations relations are generated by feedback from horizontal cell network effectively decorrelate feature representation. A model capturing zebrafish sample their environment indicates heterogeneity expands dynamic range retina improve coding natural scenes. Moreover, different kinetic components used distinct stimulus features parallel: sustained linearly encodes low amplitude dark contrasts, transient large contrasts. Together, study reveals an unprecedented degree functional within same-type illustrates separation synapse vision.
Language: Английский
Citations
2