Identification of stress-induced epigenetic methylation onto dopamine D2 gene and neurological and behavioral consequences DOI Creative Commons
Kenneth Blum, Abdalla Bowirrat, David Baron

et al.

Gene & Protein in Disease, Journal Year: 2024, Volume and Issue: 3(1), P. 1966 - 1966

Published: March 29, 2024

The D2 dopamine receptor (DRD2) gene has garnered substantial attention as one of the most extensively studied genes across various neuropsychiatric disorders. Since its initial association with severe alcoholism in 1990, particularly through identification DRD2 Taq A1 allele, numerous international investigations have been conducted to elucidate role different conditions. As February 22, 2024, there are 5485 articles focusing on listed PUBMED. There 120 meta-analyses mixed results. In our opinion, primary cause negative reports regarding polymorphisms is inadequate screening controls, not adequately eliminating many hidden reward deficiency syndrome behaviors. Moreover, pleiotropic effects variants identified neuropsychologic, neurophysiologic, stress response, social defeat, maternal deprivation, and gambling disorder, epigenetic DNA methylation histone post-translational discussed this article. 70 PUBMED for 20 October 19, 2022. For commentary, we did denote and/or methylation; instead, provided a brief summary based behavioral effects. Based fact that Blum Noble characterized allele generalized necessarily specific alcoholism, it now behooves field find ways either use effector moieties edit neuroepigenetic insults or possibly harness idea potentially removing mRNA-reduced expression by inducing “dopamine homeostasis.”

Language: Английский

Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities DOI
Wiramon Rungratanawanich,

Jacob W. Ballway,

Xin Wang

et al.

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 251, P. 108547 - 108547

Published: Oct. 13, 2023

Language: Английский

Citations

10
The Promise of Epigenetic Editing for Treating Brain Disorders DOI
Luis Alfonso González-Molina, Amalia M. Dolga, Marianne G. Rots

et al.

Sub-cellular biochemistry/Subcellular biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 111 - 190

Published: Jan. 1, 2025

Language: Английский

Citations

0
Epigenetic Insights into Substance Use Disorder and Associated Psychiatric Conditions DOI Creative Commons
A. Ngo,

Christopher M Ahmad,

Niki Gharavi Alkhansari

et al.

Complex Psychiatry, Journal Year: 2025, Volume and Issue: 11(1), P. 12 - 36

Published: March 3, 2025

Background: Substance use disorder (SUD) is closely associated with epigenetic modifications that significantly impact mental health outcomes. Alcohol and drug misuse induce widespread changes in the epigenome transcriptome of central nervous system, disrupting critical processes such as reward signaling emotional regulation. These alterations regulation gene expression often persist even after substance cessation, potentially contributing to onset or worsening psychiatric conditions, including schizophrenia, depression, stress, anxiety. Summary: This review delves into key mechanisms underlying SUD its comorbid disorders, a focus on DNA methylation, histone modifications, noncoding RNA Additionally, it examines influence environmental biological factors evaluates emerging epigenetic-based therapeutic strategies aimed at treating related conditions. Key Messages: Gaining deeper understanding driving disorders crucial for development effective interventions. highlights potential pharmacological mitigate societal personal burdens linked complications.

Language: Английский

Citations

0
Influential Attributes on Medical Expense for Korean Older Adults Based on Mental Accounting: Panel Data Analysis Using Korean Longitudinal Study of Aging Data DOI Open Access
Min Gyung Kim, Joonho Moon

Healthcare, Journal Year: 2025, Volume and Issue: 13(5), P. 558 - 558

Published: March 5, 2025

Backgrounds: Korean society is entering an aging society, and this phenomenon indicates the need for preparation in society. In such a situation, exploring characteristics of elderly can be considered important preparation. The objective study to identify determinants medical expenses among older adults South Korea. key factors analyzed include food, leisure, housing expenses, as well lifestyle choices drinking smoking. Method: Data from Longitudinal Study Aging, covering 7374 observations years 2018 2020, are adopted statistical analysis. This research explores inverted-U-shape effect expenditures on costs, grounded concepts diminishing marginal utility mental accounting. A quadratic panel regression analysis used test hypotheses, controlling variables birth year, gender, personal assets. Results: results show that food have inverted-U relationship with based accounting theoretical foundation. However, leisure drinking, smoking do not significantly affect expenses. Furthermore, identifies optimal expenditure levels maximizing spending through first-order condition. Conclusions: These findings provide insights development policies aimed at improving financial well-being Moreover, contributes literature by applying law better understand behavior adults.

Language: Английский

Citations

0
Emerging Trends and Hot Spots in Epigenetic Modifications in Neurology: A Bibliometric Analysis DOI

Shu-Ying Xu,

Siyao Zhang,

Chun-Li Zeng

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Adolescent Binge Ethanol Exposure Confers Lasting Alcohol Tolerance across a Cumulative Ethanol Challenge in Adulthood: Involvement of Proinflammatory HMGB1 Signaling DOI Creative Commons
Fulton T. Crews, Ryan P. Vetreno

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Background Epidemiological studies suggest heavy adolescent binge drinking is strongly associated with later development of an alcohol use disorder (AUD). Alcohol tolerance (i.e., acquired reduction in acute responsivity) a universally recognized symptom AUD, but the direct contribution to adult poorly understood. Methods and Materials To investigate contributions ethanol exposure lasting acquisition tolerance, we used our response battery (ERB) assess intoxication rating, hypothermia, motor coordination, balance across cumulative doses 0.0, 0.5, 1.0, 2.0, 3.0 g/kg) female Wistar rats following intermittent (AIE), lipopolysaccharide (LPS), glycyrrhizic acid treatment AIE. Results We report AIE, which models human drinking, confers blunts ethanol-induced increases proinflammatory HMGB1 plasma levels. Adolescent LPS (1.0 mg/kg, i.p.) treatment, mimics AIE-induced HMGB1-mediated neuroinflammation, induces release on ERB. Assessment involvement revealed that post-AIE administration inhibitor reversed adulthood. Conclusions These data reveal (1) long-lasting low responsivity, (2) neuroimmune activation contributes (3) blockade signaling reverses findings potential mechanistic target for novel therapeutics AUD.

Language: Английский

Citations

0
Targeting neuronal epigenomes for brain rejuvenation DOI Creative Commons
Sara Zocher

The EMBO Journal, Journal Year: 2024, Volume and Issue: 43(16), P. 3312 - 3326

Published: July 15, 2024

Abstract Aging is associated with a progressive decline of brain function, and the underlying causes possible interventions to prevent this cognitive have been focus intense investigation. The maintenance neuronal function over lifespan requires proper epigenetic regulation, accumulating evidence suggests that deterioration landscape contributes dysfunction during aging. Epigenetic aging neurons may, however, be malleable. Recent reports shown age-related changes in reversible targetable by rejuvenation strategies can restore This review discusses current identifies as driver promising target strategies, it highlights potential approaches for specific manipulation epigenome youthful state brain.

Language: Английский

Citations

3
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats DOI Creative Commons

Carlotta Gobbi,

Laura Sánchez‐Marín, María Flores-López

et al.

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 26, 2024

Language: Английский

Citations

3
From cellular to fear memory: An epigenetic toolbox to remember DOI Creative Commons

Davide Martino Coda,

Johannes Gräff

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 84, P. 102829 - 102829

Published: Dec. 20, 2023

Throughout development, the neuronal epigenome is highly sensitive to external stimuli, yet capable of safeguarding cellular memory for a lifetime. In adult brain, memories fearful experiences are rapidly instantiated, can last decades, but mechanisms underlying such longevity remain unknown. Here, we showcase how fear formation and storage – traditionally thought exclusively affect synapse-based events elicit profound enduring changes chromatin, proposing epigenetic regulation as plausible molecular template mnemonic processes. By comparing these occurring in development differentiation, notice that an machinery similar preserving might be employed by brain cells so form, store, retrieve behavioral memories.

Language: Английский

Citations

8
Researching Mitigation of Alcohol Binge Drinking in Polydrug Abuse: KCNK13 and RASGRF2 Gene(s) Risk Polymorphisms Coupled with Genetic Addiction Risk Severity (GARS) Guiding Precision Pro-Dopamine Regulation DOI Open Access
Kenneth Blum, Mark S. Brodie, Subhash C. Pandey

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(6), P. 1009 - 1009

Published: June 20, 2022

Excessive alcohol intake, e.g., binge drinking, is a serious and mounting public health problem in the United States throughout world. Hence need for novel insights into underlying neurobiology that may help improve prevention therapeutic strategies. Therefore, our group employed darkness-induced intake protocol to define reward deficiency domains of other substance use disorders terms pathways' reduced dopamine signaling its restoration via specifically-designed compounds. It has been determined KCNK13 RASGRF2 genes, respectively, code potassium two pore domain channel subfamily K member 13 Ras-specific guanine nucleotide-releasing factor 2, both genes have important dopamine-related functions pertaining drinking. We present hypothesis identification genes' risk polymorphism, coupled with genetic addiction score (GARS)-guided precision pro-dopamine regulation, will mitigate Accordingly, we review published reports on benefits this unique approach provide data favorable outcomes binge-drinking animals drunk drivers, including reductions relapse drinking behavior. Since driving under influence often leads incarceration rather than rehabilitation, there converging evidence support utilization GARS or without polymorphism legal arena, whereby argument "determinism" overrides "free will" account be plausible defense strategy. Obviously, type research tantamount helping resolve major related polydrug abuse.

Language: Английский

Citations

12