Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC DOI Creative Commons
Ling‐Shuang Zhu,

Chuan Lai,

Chao-Wen Zhou

et al.

Cell Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 20, 2024

Individuals' continuous success in competitive interactions with conspecifics strongly affects their social hierarchy. Medial prefrontal cortex (mPFC) is the key brain region mediating both competition and However, molecular regulatory mechanisms underlying neural ensemble mPFC remains unclear. Here, we demonstrate that excitatory neurons of prelimbic (PL), lncRNA Sera remodels utilization Pkm Exon9 Exon10, resulting a decrease Pkm1/2 ratio highly mice. By employing tet-on/off system, disrupt or rebuild normal by controlling expression Pkm2 PL neurons. We find long-term modulation induces timely alteration hysteretic rank change, through phosphorylating Ser845 site GluA1. Together, this study uncovers crucial role Sera/Pkm2 pathway transition to remodeling mPFC.

Language: Английский

Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knock in mouse model of Alzheimer’s disease DOI
Mattia Bonzanni, Alice Braga, Takashi Saito

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

The disease's trajectory of Alzheimer's disease (AD) is associated with and worsened by hippocampal hyperexcitability. Here we show that during the asymptomatic stage in a knock mouse model (APP

Language: Английский

Citations

2
RECCIPE: A new framework assessing localized cell-cell interaction on gene expression in multicellular ST data DOI Creative Commons
Weiping Ma, Xiaoyu Song, Guo‐Cheng Yuan

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 24, 2024

Cell-cell interaction (CCI) plays a pivotal role in cellular communication within the tissue microenvironment. The recent development of spatial transcriptomics (ST) technology and associated data analysis methods has empowered researchers to systematically investigate CCI. However, existing are tailored single-cell resolution datasets, whereas majority ST platforms lack such resolution. Additionally, detection CCI through association screening based on data, which complicated dependence structure, necessitates proper control false discovery rates due multiple hypothesis testing issue high dimensional spaces. To address these challenges, we introduce RECCIPE, novel method designed for identifying cell signaling interactions across types transcriptomic data. RECCIPE integrates gene expression information type composition multivariate regression framework, enabling genome-wide changes levels attributed CCIs. We show that not only achieves accuracy simulated datasets but also provides new biological insights from real obtained mouse model Alzheimer’s disease (AD). Overall, our framework useful tool studying impact cell-cell multicellular systems.

Language: Английский

Citations

1
Microglial purinergic signaling in Alzheimer’s disease DOI
Shuya Mei, Ning Zhang, Mengjing Wang

et al.

Purinergic Signalling, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Language: Английский

Citations

1
In vivo reactive astrocyte imaging using [18F]SMBT-1 in tauopathy and familial Alzheimer's disease mouse models: A multi-tracer study DOI
Yanyan Kong, Lei Cao, Jiao Wang

et al.

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 462, P. 123079 - 123079

Published: June 5, 2024

Language: Английский

Citations

1
Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC DOI Creative Commons
Ling‐Shuang Zhu,

Chuan Lai,

Chao-Wen Zhou

et al.

Cell Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 20, 2024

Individuals' continuous success in competitive interactions with conspecifics strongly affects their social hierarchy. Medial prefrontal cortex (mPFC) is the key brain region mediating both competition and However, molecular regulatory mechanisms underlying neural ensemble mPFC remains unclear. Here, we demonstrate that excitatory neurons of prelimbic (PL), lncRNA Sera remodels utilization Pkm Exon9 Exon10, resulting a decrease Pkm1/2 ratio highly mice. By employing tet-on/off system, disrupt or rebuild normal by controlling expression Pkm2 PL neurons. We find long-term modulation induces timely alteration hysteretic rank change, through phosphorylating Ser845 site GluA1. Together, this study uncovers crucial role Sera/Pkm2 pathway transition to remodeling mPFC.

Language: Английский

Citations

1