An exploratory study on lipidomic profiles in a cohort of individuals with posttraumatic stress disorder DOI Creative Commons
Aditi Bhargava,

Johannes D. Knapp,

Oliver Fiehn

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 2, 2024

Abstract Posttraumatic stress disorder (PTSD) can develop after trauma exposure. Some studies report that women PTSD at twice the rate of men, despite greater exposure in men. Lipids and their metabolites (lipidome) regulate a myriad key biological processes pathways such as membrane integrity, oxidative stress, neuroinflammation brain by maintaining neuronal connectivity homeostasis. In this study, we analyzed lipidome 40 adults with trauma-exposed non-PTSD individuals (n = 20/sex/condition; 19–39 years old). Plasma samples were for lipidomics using Quadrupole Time-of-Flight (QToF) mass spectrometry. Additionally, ~ 90 measures collected, on sleep, mental physical health indices. Poorer sleep quality was associated severity both sexes. The analysis identified total 348 quantifiable known lipid 1951 are yet unknown; part 13 subclasses. After adjusting BMI quality, PTSD, only one subclass, phosphatidylethanolamine (PE) altered, whereas, men 9 out subclasses altered compared to respectively. Severe 22% 5% women, Of changed metabolites, 0.5% (2 PEs cholesterol) common between PTSD. Several sphingomyelins, PEs, ceramides, triglycerides increased severe correlations ceramide cholesterol systolic blood pressure dependent upon sex status. Alterations ceramides linked cardiac metabolic function humans. Thus, disturbed higher body may have contributed changes found

Language: Английский

New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease DOI

Rohan Gupta,

Smita Kumari,

Anusha Senapati

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 102013 - 102013

Published: July 8, 2023

Language: Английский

Citations

60
Lipidome atlas of the adult human brain DOI Creative Commons
Maria Osetrova, Anna Tkachev,

Waltraud Mair

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 25, 2024

Abstract Lipids are the most abundant but poorly explored components of human brain. Here, we present a lipidome map brain comprising 75 regions, including 52 neocortical ones. The composition varies greatly among affecting 93% 419 analyzed lipids. These differences reflect brain’s structural characteristics, such as myelin content (345 lipids) and cell type (353 lipids), also functional traits: connectivity (76 information processing hierarchy (60 lipids). Combining lipid mRNA expression data further enhances association. Biochemically, lipids linked with features display distinct class distribution, unsaturation extent, prevalence omega-3 omega-6 fatty acid residues. We verified our conclusions by parallel analysis three adult macaque brains, targeted 216 lipids, mass spectrometry imaging, assessment sorted murine neurons.

Language: Английский

Citations

27
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine DOI Creative Commons
Yanhong Duo, Lei Han, Yaoqiang Yang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347

Published: Oct. 9, 2024

Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),

Language: Английский

Citations

19
Shattering the Amyloid Illusion: The Microbial Enigma of Alzheimer’s Disease Pathogenesis—From Gut Microbiota and Viruses to Brain Biofilms DOI Creative Commons
Anna Onisiforou, Eleftheria G. Charalambous, Panos Zanos

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 90 - 90

Published: Jan. 5, 2025

For decades, Alzheimer's Disease (AD) research has focused on the amyloid cascade hypothesis, which identifies amyloid-beta (Aβ) as primary driver of disease. However, consistent failure Aβ-targeted therapies to demonstrate efficacy, coupled with significant safety concerns, underscores need rethink our approach AD treatment. Emerging evidence points microbial infections environmental factors in pathoetiology. Although a definitive causal link remains unestablished, collective is compelling. This review explores unconventional perspectives and emerging paradigms regarding involvement pathogenesis, emphasizing gut-brain axis, brain biofilms, oral microbiome, viral infections. Transgenic mouse models show that gut microbiota dysregulation precedes Aβ accumulation, signaling pathways. Viral like Herpes Simplex Virus Type 1 (HSV-1) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may lead by modulating host processes immune system. peptide's antimicrobial function response infection might inadvertently promote AD. We discuss potential microbiome-based promising strategies for managing potentially preventing progression. Fecal transplantation (FMT) restores balance, reduces improves cognition preclinical models. Probiotics prebiotics reduce neuroinflammation plaques, while antiviral targeting HSV-1 vaccines shingles vaccine mitigate pathology. Developing effective treatments requires standardized methods identify measure patients, enabling personalized address individual contributions pathogenesis. Further needed clarify interactions between microbes Aβ, explore bacterial interplay, understand their broader effects translate these insights into clinical interventions.

Language: Английский

Citations

4
Lipid metabolism, remodelling and intercellular transfer in the CNS DOI
Sam Vanherle, Melanie Loix, Véronique E. Miron

et al.

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

2
Impacts of polypropylene microplastics on lipid profiles of mouse liver uncovered by lipidomics analysis and Raman spectroscopy DOI Open Access
Mingying Liu,

Ju Mu,

Miao Wang

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 458, P. 131918 - 131918

Published: June 22, 2023

Language: Английский

Citations

26
Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics DOI Creative Commons
Yaxi Luo,

Ling-Ling Yang,

Xiu‐Qing Yao

et al.

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 16, 2024

Abstract Trillions of intestinal bacteria in the human body undergo dynamic transformations response to physiological and pathological changes. Alterations their composition metabolites collectively contribute progression Alzheimer’s disease. The role gut microbiota disease is diverse complex, evidence suggests lipid metabolism may be one potential pathways. However, mechanisms that mediate pathology remain unclear, necessitating further investigation for clarification. This review highlights current understanding how disrupts discusses implications these discoveries guiding strategies prevention or treatment based on existing data.

Language: Английский

Citations

15
Cholesterol imbalance and neurotransmission defects in neurodegeneration DOI Creative Commons
Kyung Chul Shin,

Houda Yasmine Ali Moussa,

Yongsoo Park

et al.

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(8), P. 1685 - 1690

Published: Aug. 1, 2024

The brain contains the highest concentration of cholesterol in human body, which emphasizes importance physiology. Cholesterol is involved neurogenesis and synaptogenesis, age-related reductions levels can lead to synaptic loss impaired plasticity, potentially contribute neurodegeneration. maintenance homeostasis neuronal plasma membrane essential for normal function, imbalances distribution are associated with various neurodegenerative disorders, including Alzheimer's disease, Parkinson's Huntington's disease. This review aims explore molecular pathological mechanisms by imbalance neurotransmission defects neurodegeneration, focusing on four key mechanisms: (1) dysfunction, (2) alterations structure protein clustering, (3) oligomers amyloid beta (Aβ) protein, (4) α-synuclein aggregation.

Language: Английский

Citations

12
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4 DOI
Femke M. Feringa,

Sascha J. Koppes-den Hertog,

Lian Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Abstract Lipid changes in the brain have been implicated many neurodegenerative diseases including Alzheimer’s Disease (AD), Parkinson’s disease and Amyotrophic Lateral Sclerosis. To facilitate comparative lipidomic research across brain-diseases we established a data commons named Neurolipid Atlas, that pre-populated with novel human, mouse isogenic induced pluripotent stem cell (iPSC)-derived lipidomics for different diseases. We show iPSC-derived neurons, microglia astrocytes display distinct lipid profiles recapitulate vivo lipotypes. Leveraging multiple datasets, AD risk gene ApoE4 drives cholesterol ester (CE) accumulation human recapitulating CE measured brain. Multi-omic interrogation of revealed plays major role astrocyte interferon-dependent pathways such as immunoproteasome histocompatibility complex (MHC) class I antigen presentation. through enhanced esterification suppresses immune activation astrocytes. Our commons, available at neurolipidatlas.com, provides user-friendly tool knowledge base better understanding dyshomeostasis

Language: Английский

Citations

10
The ABC's of Alzheimer risk gene ABCA7 DOI Creative Commons
Lena Duchateau, Nicole Wawrzyniak, Kristel Sleegers

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(5), P. 3629 - 3648

Published: March 31, 2024

Alzheimer's disease (AD) is a growing problem worldwide. Since ABCA7's identification as risk gene, it has been extensively researched for its role in the disease. We review recently characterized structure and what mechanistic insights teach us about function. furthermore provide an overview of identified ABCA7 mutations, their presence different ancestries protein domains how they might cause AD. For PTC variants VNTR expansion, haploinsufficiency proposed most likely mode-of-action, although splice events could further influence risk. Overall, need to better understand expression canonical isoforms indicated. Finally, potential functions lipid metabolism, phagocytosis, amyloid deposition, interplay between these three, described. To conclude, this review, we comprehensive discussion current knowledge on AD, research questions remain. HIGHLIGHTS: risk-increasing can be found up 7% AD patients. ABCA7. present latest genetics, patterns,

Language: Английский

Citations

9