Annals of Neurology, Journal Year: 2023, Volume and Issue: 95(2), P. 274 - 287
Published: Oct. 14, 2023
We aimed to test whether region-specific factors, including spatial expression patterns of the tau-encoding gene MAPT and regional levels amyloid positron emission tomography (PET), enhance connectivity-based modeling variability in tau-PET deposition Alzheimer disease (AD) spectrum.
Language: Английский
European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: May 6, 2025
Language: Английский
Citations
0
Neuroglia, Journal Year: 2025, Volume and Issue: 6(2), P. 22 - 22
Published: May 6, 2025
This review synthesizes the emerging understanding of roles glial cells and non-coding RNAs (ncRNAs) in pathogenesis progression Alzheimer’s disease related dementias (ADRDs). ADRDs encompass a spectrum neurodegenerative disorders characterized by cognitive decline, memory impairment, functional deterioration. The interplay between most common types cells—astrocytes, microglia, oligodendrocytes—and ncRNAs is as critical factor development ADRDs. Glial are essential for maintaining homeostasis within central nervous system (CNS); however, their dysregulation can lead to neuroinflammation neuronal dysfunction, exacerbating neurodegeneration. Reactive astrocytes activated microglia create neurotoxic environments that further impair health. Concurrently, ncRNAs, particularly long (lncRNAs) microRNAs (miRNAs), have emerged significant regulators gene expression, influencing inflammatory responses cell function. Understanding complex interactions crucial developing targeted therapeutic strategies. By elucidating mechanisms underlying interactions, this aims highlight importance context diseases, paving way innovative approaches prevent treat Ultimately, enhancing our these processes may novel therapies improved outcomes individuals affected debilitating conditions.
Language: Английский
Citations
0
Current Opinion in Neurology, Journal Year: 2023, Volume and Issue: 36(5), P. 481 - 490
Published: Aug. 3, 2023
The purpose is to review the latest advances of brain imaging for diagnosis Alzheimer disease (AD).Brain techniques provide valuable and complementary information support in clinical research settings. recent FDA accelerated approvals aducanumab, lecanemab donanemab made amyloid-PET critical helping determine optimal window anti-amyloid therapeutic interventions. Tau-PET, on other hand, considered key importance tracking progression monitoring interventions trials. PET microglial activation, astrocyte reactivity synaptic degeneration are still new only used field, more studies needed validate their use AD. Finally, artificial intelligence has opened prospective early detection AD using MRI modalities.Brain improve our understanding different AD-related pathologies relationship with each along course disease. With robust validation, machine learning deep algorithms could be integrated neuroimaging modalities serve as tools clinicians make prognosis
Language: Английский
Citations
9
Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15
Published: June 16, 2023
More women have Alzheimer disease (AD) than men, but the reasons for this phenomenon are still unknown. Including in clinical research and studying their biology is key to understand not just increased risk also resilience against disease. In sense, more affected by AD reserve or mechanisms might delay symptom onset. The aim of review was explore what known about underlying women’s identify emerging themes area that merit further research. We conducted a studies analyzing molecular may induce neuroplasticity women, as well cognitive brain reserve. analyzed how loss steroid hormones aging be linked AD. included empirical with human animal models, literature reviews meta-analyses. Our search identified importance 17-b-estradiol (E2) mechanism driving women. broadly, our analysis revealed following perspectives: (1) effects on both neurons glia study AD, (2) E2’s crucial role reserve, (3) verbal memory advantage factor, (4) potential linguistic experiences such multilingualism hearing loss. Future directions include neuronal glial plasticity, identifying links between hormone
Language: Английский
Citations
6
Annals of Neurology, Journal Year: 2023, Volume and Issue: 95(2), P. 274 - 287
Published: Oct. 14, 2023
We aimed to test whether region-specific factors, including spatial expression patterns of the tau-encoding gene MAPT and regional levels amyloid positron emission tomography (PET), enhance connectivity-based modeling variability in tau-PET deposition Alzheimer disease (AD) spectrum.
Language: Английский
Citations
5