Precision microbial regulation: Strategies for modulating GIT microbiota for host health DOI Creative Commons

Zhong Pei,

Qin Li, Yanmei Zhang

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Recent advancements in analytical techniques have unveiled the spatiotemporal diversity of gastrointestinal tract (GIT) microbiota and their associations with host well‐being. Despite these insights, precise regulation GIT remains a significant challenge. Currently, microbial regulatory strategies, including fecal transplantation (FMT), synthetic communities (SynComs), genetically engineered microorganisms (GEMs), phages, nanomaterials, are increasingly utilized for influence on microbiota. This review emphasizes necessity developing targeted strategies provides comprehensive summary comparison approaches to explore potential. We discuss recent focusing mechanisms, efficacy, safety considerations, clinical trials, optimization at application level. Finally, we highlight support methods optimizing modulation timing regulation, selection targets, importance monitoring environment guide effective interventions.

Language: Английский

Synthesis, characterization, and antibacterial effect of St. John's wort oil loaded chitosan hydrogel DOI
İlter DEMİRHAN, Ahmet Korkmaz, Erkan Öner

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129444 - 129444

Published: Jan. 21, 2024

Language: Английский

Citations

7
Eumelanin-like Poly(levodopa) Nanoscavengers for Inflammation Disease Therapy DOI

Xianheng Wang,

Jianhua Zhang, Lei Yang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2563 - 2573

Published: March 14, 2024

In the current years, polydopamine nanoparticles (PDA NPs) have been extensively investigated as an eumelanin mimic. However, unlike natural eumelanin, PDA NPs contain no 5,6-dihydroxyindole-2-carboxylic acid (DHICA)-derived units and may be limited in certain intrinsic properties; superior eumelanin-like nanomaterials are still actively being sought. Levodopa (l-DOPA) is a precursor expected to convert into DHICA further remain within final product through covalent or physical interactions. Herein, poly(levodopa) [P(l-DOPA) NPs] were synthesized with assistance of zinc oxide supplement synthetic eumelanin. This study found that P(l-DOPA) had ∼90% DHICA-derived subunits on their surface exhibited antioxidant activity compared due looser polymeric microstructure. Benefitting from stronger ROS scavenging ability, outperformed treating cellular oxidative stress acute inflammation. research opens up new possibilities for development application novel melanin-like materials.

Language: Английский

Citations

7
Tannic acid based multifunctional hydrogels with mechanical stability for wound healing DOI
Lanlan Dong, Ru Jia, Zhong Liu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 243, P. 114127 - 114127

Published: July 26, 2024

Language: Английский

Citations

7
Recent development of micro-nano carriers for oral antineoplastic drug delivery DOI Creative Commons
Hongzheng Li, Xiang Chen,

Shangrui Rao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101445 - 101445

Published: Jan. 5, 2025

Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral stands prevailing utilized method delivering chemotherapy drugs. However, majority anti-tumor medications exhibit limited solubility permeability, poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy chemotherapy. Therefore, more micro-nano drug delivery carriers have been developed used effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate administration, ultimately improve efficacy. In this paper, we first discuss effects various biological barriers on approach. Then, development based biomedical components, such micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, current dilemma potential clinical treatment discussed. The primary objective review introduce methods serve point reference advancement novel carriers, with ultimate goal informing future applications.

Language: Английский

Citations

1
Precision microbial regulation: Strategies for modulating GIT microbiota for host health DOI Creative Commons

Zhong Pei,

Qin Li, Yanmei Zhang

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Recent advancements in analytical techniques have unveiled the spatiotemporal diversity of gastrointestinal tract (GIT) microbiota and their associations with host well‐being. Despite these insights, precise regulation GIT remains a significant challenge. Currently, microbial regulatory strategies, including fecal transplantation (FMT), synthetic communities (SynComs), genetically engineered microorganisms (GEMs), phages, nanomaterials, are increasingly utilized for influence on microbiota. This review emphasizes necessity developing targeted strategies provides comprehensive summary comparison approaches to explore potential. We discuss recent focusing mechanisms, efficacy, safety considerations, clinical trials, optimization at application level. Finally, we highlight support methods optimizing modulation timing regulation, selection targets, importance monitoring environment guide effective interventions.

Language: Английский

Citations

1