Modulation of cerebellar-cortical connectivity induced by modafinil and its relationship with receptor and transporter expression DOI Creative Commons
Stefano Delli Pizzi,

Federica Tomaiuolo,

Antonio Ferretti

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 10(3), P. 304 - 313

Published: Nov. 26, 2024

Modafinil is primarily used to treat narcolepsy but also as an off-label cognitive enhancer. Functional magnetic resonance imaging studies indicate that modafinil modulates the connectivity of neocortical networks involved in attention and executive functions. However, much less known about drug's effects on subcortical structures. Following preliminary findings, we evaluated modafinil's activity distinct cerebellar regions with neocortex. We assessed spatial relationship these expression neurotransmitter receptors/transporters. Patterns resting-state functional were estimated 50 participants from scans acquired pre- postadministration a single (100 mg) dose (n = 25) or placebo 25). Using specific seeds for voxelwise analyses, examined modulation cerebellar-neocortical connectivity. Next, conducted quantitative evaluation overlap between receptors/transporters obtained by publicly available databases. increased crus I vermis IX prefrontal regions. Crus changes associated dopaminergic D2 receptors. The I-II showed enhanced coupling dorsal anterior cingulate cortex matched histaminergic H3 VII-VIII displayed visual cortex, neurotransmission. Our study reveals modulatory mainly involves spatially overlaps distribution

Language: Английский

Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine‐D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture DOI Creative Commons
Liyong Yu, Lili Yang, Xiaoqin Chen

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(4)

Published: March 1, 2025

ABSTRACT This study integrated neuroimaging and neurochemistry data to explore brain mechanisms in chronic insomnia disorder (CID) the neuromodulatory effects of acupuncture. We analyzed a cross‐sectional arterial spin labeling (ASL) dataset ( N = 197) CID patients healthy controls identify cerebral blood flow (CBF) changes. Additionally, longitudinal ASL 44) examined CBF changes after 4‐week acupuncture treatment or on waitlist. then assessed impact 19 neurotransmitter receptors/transporters these alterations. In comparisons, exhibited increased cortical areas decreased subcortical regions, correlating with severity. enhanced alleviated symptoms, not observed waitlist group. The left putamen was identified as an overlapping region involved both CID‐related post‐treatment Moreover, patterns induced by negatively correlated abnormal patients, were significantly associated GABAa dopamine‐D1 receptor densities. decrease could potentially serve neural biomarker for CID, while may alleviate symptoms increasing this region, through modulation D1 expressions.

Language: Английский

Citations

0
Disorders of Consciousness and pharmacotherapy: a systematic update on drugs inducing consciousness improvement DOI
Davide Cardile, Lilla Bonanno, Rosella Ciurleo

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177532 - 177532

Published: March 1, 2025

Language: Английский

Citations

0
Local Orchestration of Global Functional Patterns Supporting Loss and Restoration of Consciousness in the Primate Brain DOI Creative Commons
Andrea I. Luppi, Lynn Uhrig, Jordy Tasserie

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 3, 2023

Abstract A central challenge of neuroscience is to elucidate how the orchestration brain function modulated by different states consciousness. Here, we investigate link between distributed structural and functional organisation in MRI signals non-human primates, through bi-directional causal manipulations During varying levels propofol, sevoflurane, or ketamine anaesthesia, subsequent restoration responsiveness deep stimulation thalamus, loss consciousness impacts patterns structure-function across scales. Combining specificity electrical with global fMRI coverage entire cortex, report that activity under anaesthesia increasingly constrained structure scales, coinciding anaesthetic-induced collapse multiple dimensions hierarchical cortical organisation. Crucially, show these signatures are observed anaesthetics, they reversed recovery behavioural markers during propofol anaesthesia. No such effects were upon a control anatomical site, ventral lateral demonstrating specificity. Through integrate pharmacology intracranial our results identify local specific nuclei thalamus. Overall, present work broadens understanding network supporting consciousness, interplay architecture.

Language: Английский

Citations

10
Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications DOI Creative Commons
Taynah Pereira Galdino, Lucas Cordeiro de Oliveira, Mateus Araújo da Luz

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 380 - 380

Published: March 7, 2025

The growing body of evidence supporting the therapeutic efficacy psychoactive substances, like psilocybin, has driven significant interest in recent decades due to their low toxicity and potential applications treating various mental health disorders. However, producing pharmaceutical-grade psilocybin remains challenging, with three primary approaches: chemical synthesis, biosynthesis, extraction from Psilocybe mushroom fruiting bodies. This systematic review evaluates quantification methods for psilocin, aiming contribute development standardized protocols that ensure compound quality purity. A total 25 relevant studies were selected an initial pool 9152 publications indexed platforms such as Scopus, ScienceDirect, Web Science, PubMed. findings indicate both method choice species significantly influence yields. Ultrasonic bath was identified most efficient technique, particularly including cyanescens cubensis. High-performance liquid chromatography (HPLC) most-used identifying quantifying these compounds. Furthermore, polar solvents critical effective solubilization, parameters temperature, solvent-to-material ratio, time playing key roles optimizing serves a scientific reference advancing research, enhancing analytical precision, ensuring reproducibility through standardization protocols.

Language: Английский

Citations

0
A comprehensive review of neurotransmitter modulation via artificial intelligence: A new frontier in personalized neurobiochemistry DOI

Jaleh Bagheri Hamzyan Olia,

Arasu Raman, Chou‐Yi Hsu

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 189, P. 109984 - 109984

Published: March 14, 2025

Language: Английский

Citations

0
Modafinil alters the functional connectivity of distinct thalamic nuclei with the neocortex DOI Creative Commons
Stefano Delli Pizzi,

Federica Tomaiuolo,

Carlo Sestieri

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121242 - 121242

Published: April 1, 2025

Modafinil promotes wakefulness and enhances cognitive function through mechanisms neural effects that are still partially unknown. Several studies have shown the compound alters functional cortical architecture. In contrast, its influence on subcortical regions thalamocortical connections, which crucial for modulating neocortical connectivity, remains unexplored. The acute modulation of thalamo-cortical connectivity was assessed in two groups participants who received either a single 100 mg dose modafinil (N=25) or placebo (N=25). Magnetic Resonance Imaging (MRI) used to parcel thalamus into constituent nuclei, served as seeds voxel-wise resting state analyses. Additionally, maps nuclei-specific reorganization were compared those receptor/transporter expression assess their spatial overlaps. Modafinil, but not placebo, altered three thalamic nuclei. Specifically, medial pulvinar nuclei showed increased with Sensorimotor Salience/Ventral Attention (SVAN) Networks. These changes spatially overlapped distribution norepinephrine transporter (NET). anterior inferior complex exhibited enhanced insular supramarginal SVAN superior frontal area Default Mode Network (DMN). However, unlike pulvinar, these linked any specific receptor transporter. Finally, ventrolateral posterior region DMN FrontoParietal Network, along decreased premotor cortex. topography modifications mainly overlaps glutamatergic serotonergic receptors. summary, our findings highlight modafinil's circuits, emphasizing role higher-order complex.

Language: Английский

Citations

0
Acute changes in functional connectivity associated with first osteopathic manual treatment in chronic low back pain spatially overlap with opioid receptor expression DOI Creative Commons

Federica Tomaiuolo,

Francesco Cerritelli, Carlo Sestieri

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111375 - 111375

Published: May 1, 2025

Language: Английский

Citations

0
Brain connectivity changes to fast versus slow dopamine increases DOI Creative Commons
Peter Manza, Dardo Tomasi,

Leah Vines

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(6), P. 924 - 932

Published: Feb. 7, 2024

The rewarding effects of stimulant drugs such as methylphenidate (MP) depend crucially on how fast they raise dopamine in the brain. Yet rate drug-induced increases impacts brain network communication remains unresolved. We manipulated route MP administration to generate versus slow increases. hypothesized that would result a differential pattern global connectivity (GBC) association with regional levels D1 receptors, which are critical for drug reward. Twenty healthy adults received intravenously (0.5 mg/kg; increases) and orally (60 mg; during simultaneous [

Language: Английский

Citations

3
Whole-brain modelling supports the use of serotonergic psychedelics for the treatment of disorders of consciousness DOI Creative Commons
Iván Mindlin, Rubén Herzog, Laouen Belloli

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 30, 2023

Abstract Disorders of consciousness (DoC) are a challenging and complex group neurological conditions characterised by absent or impaired awareness. The current range therapeutic options for DoC patients is limited, offering few non-invasive pharmacological alternatives. This situation has sprung growing interest in the development novel treatments, such as proposal to study efficacy 5HT2A receptor agonists (also known psychedelics) restore consciousness. Given ethical implications exploring compounds non-communicative individuals, we assessed silico their effects whole-brain dynamics patients. We embedded activity low-dimensional space, then used this representation visualise simulated neuromodulation across receptors representing potential drug targets. Our findings show that activation serotonergic opioid shifted brain towards patterns typically seen conscious awake effect was mediated brain-wide density activated receptors. These results showcase role models discovery treatments neuropsychiatric conditions, while also supporting feasibility accelerating recovery with psychedelics.

Language: Английский

Citations

7
Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness DOI Creative Commons
Iván Mindlin, Rubén Herzog, Laouen Belloli

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Sept. 19, 2024

Language: Английский

Citations

2