Microbial education plays a crucial role in harnessing the beneficial properties of microbiota for infectious disease protection in Crassostrea gigas DOI Creative Commons
Luc Dantan,

Prunelle Carcassonne,

Lionel Dégremont

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 6, 2024

Abstract The increase in marine diseases, particularly economically important mollusks, is a growing concern. Among them, the Pacific oyster ( Crassostrea gigas ) production faces challenges from several such as Oyster Mortality Syndrome (POMS) or vibriosis. microbial education, which consists of exposing host immune system to beneficial microorganisms during early life stages promising approach against diseases. This study explores concept education using controlled and pathogen-free bacterial communities assesses its protective effects POMS Vibrio aestuarianus infections, highlighting potential applications production. We demonstrate that it possible educate by adding larval stage. Adding culture based mixes larvae protects only disease while whole donors both efficiency protection depends on origin composition used for exposure. No preferential was observed when oysters were stimulated with their sympatric strains. Furthermore, added bacteria not maintained into microbiota, but this addition induced long term changes microbiota gene expression. Our reveals successful introducing improved long-term resistance critical diseases (POMS infections) aquaculture.

Language: Английский

Diseases of marine fish and shellfish in an age of rapid climate change DOI Creative Commons
Andrew F. Rowley, Craig Baker‐Austin, Annette S. Boerlage

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110838 - 110838

Published: Aug. 28, 2024

Language: Английский

Citations

9
DNA methylation landscapes before and after Pacific Oyster Mortality Syndrome are different within and between resistant and susceptible Magallana gigas DOI

Alejandro Valdivieso,

Benjamín Morga, Lionel Dégremont

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 962, P. 178385 - 178385

Published: Jan. 1, 2025

Language: Английский

Citations

1
Epigenetic variation in light of population genetic practice DOI Creative Commons
Sarah A. Mueller, Justin Meröndun, Sonja Lečić

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 25, 2025

The evolutionary impact of epigenetic variation depends on its transgenerational stability and source - whether genetically determined, environmentally induced, or due to spontaneous, genotype-independent mutations. Here, we evaluate current approaches for investigating an independent role epigenetics in evolution, pinpointing methodological challenges. We further identify opportunities arising from integrating data with population genetic analyses natural populations. Efforts advance quality, study design, statistical treatment are encouraged consolidate our understanding the heritable variation, quantify autonomous potential enrich additional layer information.

Language: Английский

Citations

1
Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life DOI Creative Commons
Delphine Destoumieux‐Garzón, Caroline Montagnani, Luc Dantan

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1901)

Published: March 18, 2024

The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected to rapid environmental changes. It harbours a diversified and fluctuating microbiota that cohabits with immune cells expressing gene repertoire. In the early stages of development, just after fertilization, plays key role educating system. Exposure rich microbial environment at larval stage leads an increase competence throughout life oyster, conferring better protection against pathogenic infections later juvenile/adult stages. This beneficial effect, which is intergenerational, associated epigenetic remodelling. At juvenile stages, educated system participates control homeostasis. particular, fine-tuned by antimicrobial peptides acting through specific synergistic effects. However, this balance fragile, as illustrated Oyster Mortality Syndrome, disease causing mass mortalities oysters worldwide. disease, weakening defences OsHV-1 µVar virus induces dysbiosis leading fatal sepsis. review illustrates continuous interaction between highly its dynamic life, importance cross-talk for health. article part theme issue ‘Sculpting microbiome: how host factors determine respond colonization’.

Language: Английский

Citations

7
Redox control of antioxidants, metabolism, immunity, and development at the core of stress adaptation of the oyster Crassostrea gigas to the dynamic intertidal environment DOI Creative Commons
Rafael Trevisan, Danielle F. Mello

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 210, P. 85 - 106

Published: Nov. 11, 2023

Language: Английский

Citations

14
Ancestors’ Gift: Parental Early Exposure to the Environmentally Realistic Pesticide Mixture Drives Offspring Phenotype in a Larger Extent Than Direct Exposure in the Pacific Oyster, Crassostrea gigas DOI
Thomas Sol Dourdin, Killian Guyomard, Manuella Rabiller

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(4), P. 1865 - 1876

Published: Jan. 13, 2024

Marine organisms are threatened by the presence of pesticides in coastal waters. Among them, Pacific oyster is one most studied invertebrates marine ecotoxicology where numerous studies highlighted multiscale impacts pesticides. In past few years, a growing body literature has reported epigenetic outcomes xenobiotics. Because DNA methylation an mark implicated organism development and meiotically heritable, it raises question multigenerational implications xenobiotic-induced alterations. Therefore, we performed exposure to environmentally relevant mixture 18 (nominal sum concentration: 2.85 μg·L

Language: Английский

Citations

4
Hemolymph microbiota and immune effectors’ expressions driven by geographical rearing acclimation of the aquacultured Penaeus stylirostris DOI Creative Commons
Valérie Perez,

Viviane Boulo,

Julien de Lorgeril

et al.

Animal Microbiome, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

In holobiont, microbiota is known to play a central role on the health and immunity of its host. Then, understanding microbiota, dynamic according environmental conditions link would help react potential dysbiosis aquacultured species. While gut highly studied, in marine invertebrates hemolymph often set aside even if it remains an important actor homeostasis. Indeed, harbors factors involved animal homeostasis that interacts with immunity. Southwest Pacific, high economical valued shrimp Penaeus stylirostris reared two contrasted sites, New Caledonia (NC) French Polynesia (FP). We characterized active inhabiting shrimps while considering stability during seasons at one-month interval evidenced microbial variability between rearing sites. highlighted specific biomarkers along common core composed 6 ASVs. Putative functions were mostly associated bacterial competition, infections metabolism NC, they cell FP suggesting site discrimination. Differential relative expression immune effectors measured populations from NC FP, exhibited higher level compared FP. addition, differential was correlated based their geographical location. Our data suggest that, Pacific shrimps, both could have undergone immunostimulation as well adaptative divergence Further, identification proxies such biomarkers, be used guide future actions monitor thus preserve productions.

Language: Английский

Citations

0
DNA Methylation of Somatic Tissues in Oysters is Influenced by Sex and Heredity DOI
Wen Teng,

Chengxun Xu,

Shikai Liu

et al.

Marine Biotechnology, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 14, 2025

Language: Английский

Citations

0
Experimentally mimicking 30 years of Magallana gigas infections with the OsHV-1 virus reveals evolution through positive selection DOI Creative Commons
Camille Pelletier,

Nicole Faury,

Mickaël Mege

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Abstract Ostreid herpesvirus 1 (OsHV-1) poses a significant threat to the global oyster farming industry, causing substantial economic losses due mortality outbreaks. While OsHV-1 primarily affects Pacific Magallana gigas , it has been linked events in various host species. Despite advancements understanding epidemiology, knowledge gaps persist regarding its evolutionary mechanisms and adaptation genetic backgrounds. This study employs experimental evolution extensive genomic analysis unravel dynamics of response variation. Our results show that mutations, particularly transitions transversions, played role shaping viral population, leading trend toward homogenization. Stronger positive selection signals were observed population with higher susceptibility, suggesting genotypes specific These findings shed light on complex interactions hosts. Understanding how this virus adapts diversity is crucial for developing strategies mitigate impact industry provides valuable insights into broader

Language: Английский

Citations

0
DNA methylation provides new insights into the epigenetic regulation of Vibrio parahaemolyticus infection in Portunus trituberculatus DOI

Dongfang Sun,

Xudong Zhou,

Shaoting Jia

et al.

Aquaculture Reports, Journal Year: 2025, Volume and Issue: 41, P. 102693 - 102693

Published: March 3, 2025

Language: Английский

Citations

0