Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
The
E3
ubiquitin
ligase
RNF112
is
significantly
downregulated
in
bladder
cancer
(BLCA)
and
correlated
with
disease
progression.
In
vitro
vivo
studies
indicated
that
suppresses
BLCA
cell
proliferation,
migration,
lipid
synthesis.
Mechanistically,
directly
interacts
the
MB
II
domain
of
MYC
through
its
N-terminal
zinc
finger
motif,
catalytic
site
C97
facilitates
K48-linked
polyubiquitination
K389
residue
on
c-Myc
protein,
accelerating
degradation.
Additionally,
this
research
validated
interaction
promoter
ATP
citrate
lyase
(ACLY),
a
central
enzyme
metabolism,
promoting
transcriptional
activity.
restoration
or
ACLY
expression
attenuated
inhibitory
effects
growth,
conclusion,
study
confirmed
suppressed
synthesis
cells
by
facilitating
ubiquitin-mediated
degradation
c-Myc.
Trends in Pharmacological Sciences,
Journal Year:
2024,
Volume and Issue:
45(6), P. 537 - 551
Published: May 17, 2024
Cancer
cells
perturb
lipid
metabolic
pathways
for
a
variety
of
pro-tumorigenic
functions,
and
deregulated
cellular
metabolism
is
hallmark
cancer
cells.
Although
alterations
in
have
been
appreciated
over
20
years,
there
are
no
FDA-approved
treatments
that
target
lipid-related
pathways.
Recent
advances
pertaining
to
cell
fatty
acid
synthesis
(FAS),
desaturation,
uptake,
microenvironmental
dietary
lipids,
tumor-infiltrating
immune
illuminated
promising
clinical
applications
targeting
metabolism.
This
review
highlights
emerging
targets
tumor
may
soon
impact
treatment.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2025,
Volume and Issue:
unknown, P. 189259 - 189259
Published: Jan. 1, 2025
As
immunosuppressive
cells,
Regulatory
T
cells
(Tregs)
exert
their
influence
on
tumor
immune
escape
within
the
microenvironment
(TME)
by
effectively
suppressing
activity
of
other
thereby
significantly
impeding
anti-tumor
response.
In
recent
years,
metabolic
characteristics
Tregs
have
become
a
focus
research,
especially
important
role
lipid
metabolism
in
maintaining
function
Tregs.
Consequently,
targeted
interventions
aimed
at
modulating
been
recognized
as
an
innovative
and
promising
approach
to
enhance
effectiveness
immunotherapy.
This
review
presents
comprehensive
overview
pivotal
regulating
Tregs,
with
specific
targeting
augment
responses.
Furthermore,
we
discuss
potential
opportunities
challenges
associated
this
strategy,
aiming
provide
novel
insights
for
enhancing
efficacy
cancer
Hepatology,
Journal Year:
2024,
Volume and Issue:
80(3), P. 536 - 551
Published: March 27, 2024
Tumor
microenvironment
(TME)
heterogeneity
leads
to
a
discrepancy
in
survival
prognosis
and
clinical
treatment
response
for
patients
with
HCC.
The
applications
of
documented
molecular
subtypes
are
constrained
by
several
issues.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4717 - 4737
Published: July 27, 2024
Over
the
past
decade,
research
has
increasingly
identified
unique
dysregulations
in
lipid
metabolism
within
tumor
microenvironment
(TME).
Lipids,
diverse
biomolecules,
not
only
constitute
biological
membranes
but
also
function
as
signaling
molecules
and
energy
sources.
Enhanced
synthesis
or
uptake
of
lipids
TME
significantly
promotes
tumorigenesis
proliferation.
Moreover,
secreted
into
influence
tumor-resident
immune
cells
(TRICs),
thereby
aiding
survival
against
chemotherapy
immunotherapy.
This
review
aims
to
highlight
recent
advancements
understanding
both
TRICs,
with
a
particular
emphasis
on
exogenous
endogenous
Seminars in Cancer Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Elevated
lipid
metabolism
is
one
of
hallmarks
malignant
tumors.
Lipids
not
only
serve
as
essential
structural
components
biological
membranes
but
also
provide
energy
and
substrates
for
the
proliferation
cancer
cells
tumor
growth.
Cancer
meet
their
needs
by
coordinating
processes
absorption,
synthesis,
transport,
storage,
catabolism.
As
research
in
this
area
continues
to
deepen,
numerous
new
discoveries
have
emerged,
making
it
crucial
scientists
stay
informed
about
developments
metabolism.
In
review,
we
first
discuss
relevant
concepts
theories
or
assumptions
that
help
us
understand
-based
therapies.
We
then
systematically
summarize
latest
advancements
including
mechanisms,
novel
targets,
up-to-date
pre-clinical
clinical
investigations
anti-cancer
treatment
with
targeted
drugs.
Finally,
emphasize
emerging
directions
therapeutic
strategies,
future
prospective
challenges.
This
review
aims
insights
guidance
field
