Chronic Pain and Comorbid Emotional Disorders: Neural Circuitry and Neuroimmunity Pathways

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 436 - 436

Published: Jan. 7, 2025

Chronic pain is a multidimensional experience that not only involves persistent nociception but also frequently accompanied by significant emotional disorders, such as anxiety and depression, which complicate its management amplify impact. This review provides an in-depth exploration of the neurobiological mechanisms underlying comorbidity chronic disturbances. Key areas focus include dysregulation major neurotransmitter systems (serotonin, gamma-aminobutyric acid, glutamate) resulting functional remodeling critical neural circuits implicated in processing, regulation, reward. Given contribution neuroimmune to chronicity mood we further conducted investigation into role factors, including resident immune cells, infiltrating release inflammatory mediators. discusses current therapeutic strategies, encompassing pharmacological interventions, neuromodulation, integrative approaches, emphasizes necessity targeted treatments address both components. Finally, it identifies gaps understanding outlines future research directions aimed at elucidating complex interplay between thereby laying foundation for more effective holistic treatment paradigms.

Language: Английский

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Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVN^CRH Neurons via GABA_A Receptor β3 Subunits

Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)

Published: April 19, 2024

Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role in pain-associated is not yet described. This study investigates therapeutic potential single dose propofol (100 mg kg

Language: Английский

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Chronic Neuropathic Pain and Comorbid Depression Syndrome: From Neural Circuit Mechanisms to Treatment

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(13), P. 2432 - 2444

Published: June 25, 2024

Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide health problem that affects the quality of life patients imposes tremendous socioeconomic burden. More than half with chronic also suffer from moderate or severe depression. Due to complex pathogenesis CDS, there are no effective therapeutic drugs available. The lack research on neural circuit mechanisms CDS limits development treatments. purpose this article provide an overview various circuits involved in CDS. Notably, activating some can alleviate and/or depression, while other exacerbate these conditions. Moreover, we discuss current emerging pharmacotherapies for such as ketamine. Understanding may clues novel drug treatments improved management.

Language: Английский

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Role of Prefrontal Cortex Circuitry in Maintaining Social Homeostasis

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

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CD38-mediated oxytocin signaling in paraventricular nucleus contributes to empathic pain

Neuropharmacology, Journal Year: 2025, Volume and Issue: 267, P. 110301 - 110301

Published: Jan. 13, 2025

Language: Английский

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Enhancing mPFC to BLA information transmission through chemical genetics to improve exploratory behavior in chronic stress rats

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 225, P. 111335 - 111335

Published: April 8, 2025

The pathogenesis of depression is fundamentally linked to the dysregulation neural circuit structure and function. Notably, medial prefrontal cortex (mPFC) basolateral amygdala (BLA) are critical brain regions in regulation depression-related behaviors. Depressed rats exhibited attenuated messaging between mPFC BLA, along with abnormally enhanced theta oscillations BLA during execution an exploratory task. However, whether specific activation improves behavior recovery mediated by mPFC-BLA circuitry unknown. We modeled using chronic unpredictable mild stimulation (CUMS) employed chemogenetic approaches selectively activate glutamatergic neurons depressed rats. Through simultaneous monitoring behavioral patterns local field potentials (LFPs) both open-field exploration, we conducted comparative analyses chemogenetically activated sham-stimulated groups. Our investigation focused on oscillation dynamics, network connectivity strength, interregional information transfer behavior. results demonstrated that not only ameliorated deficits but also mPFC-to-BLA while attenuating oscillations. These findings suggest restoration flow may play a crucial role improving behavior, thereby revealing potential mechanism underlying depressive state modulation.

Language: Английский

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Association between mental disorders and trigeminal neuralgia: a cohort study and Mendelian randomization analysis

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 11, 2025

Clinical observational evidence suggests a close association between Trigeminal Neuralgia (TN) and Mental disorders (MDs). However, the causal relationship two remains unclear. This study aims to observe analyse associations depression, anxiety, insomnia, TN through clinical research. It also employs Mendelian randomization (MR) analysis verify potential genetic correlation various mental disorders. offering new insights for diagnosis, prevention, intervention strategies TN. In cohort section, data were collected from 154 patients with TN, all of whom excluded preoperative use psychotropic drugs such as carbamazepine. The PHQ-9, GAD-7, ISI scales used assess symptoms insomnia. Multivariable linear regression models identify factors associated questionnaire scores, model performance evaluated by adjusted R², AIC, BIC, p-values. Patients significant positive preoperatively followed up one-year after surgery, non-parametric tests employed examine changes in disorder pain relief. MR main methods include Inverse Variance Weighted (IVW), Egger, Median, Simple Mode, Mode. Benjamini-Hochberg (BH) method was adjust p -values ​​and control false discovery rate (FDR). Subsequent sensitivity analyses involved Cochran's Q test, MR-Egger intercept, MR-pleiotropy residual sum outlier test (MR-PRESSO). Multiple revealed that longer disease duration greater involvement trigeminal branches consistently higher while demographic baseline BNI scores showed no predictive value. indicated autism (OR = 0.697, 95% CI [0.494-0.982], P 0.039), schizophrenia 0.910, [0.831-0.997], 0.042), ADHD combined OCD 0.175, [0.044-0.693], 0.013) reduced risk Conversely, bipolar 1.249, [1.016-1.535], 0.034), depression 2.375, [1.043-5.409], anxiety 1.174, [1.008-1.368], insomnia 2.036, [1.074-3.861], 0.029)increased elevated 1.43, [1.04-1.96], 1.00305, [1.00036-1.00549], 0.013), 1.00918, [1.00236-1.01605], 0.008). Longer broader nerve independently increased severity depressive, symptoms, highlighting importance early And results provide supporting MDs contrast traditional view causes mood variety alter developing

Language: Английский

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Bi-directional causal association between 17 neurosurgical diseases and three emotional disorders: perspective from Mendelian randomization analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Background Although numerous studies have reported correlations between emotional disorders and neurosurgical conditions, their causal relationships is not convincing. Therefore, we seek to comprehensively investigate the connection two using bidirectional Mendelian randomization studies. Methods The GWAS aggregated data encompassed 17 types of diseases (including cerebrovascular diseases, functional disorders, central nervous system neoplasms, spinal cord other brain conditions) 3 (anxiety, mania, depression), sourced from IEU FINNGEN. The primary analysis method applied was inverse variance-weighted (IVW) analysis, supplemented by MR-Egger weighted median methods ensure robust estimates. A series sensitivity analyses, including Cochran’s Q test, regression, leave-one-out were conducted detect pleiotropy or heterogeneity. Results IVW estimates indicated that trigeminal neuralgia significantly associated with risk mania (p=0.002, odds ratio [OR]=1.008, 95 % confidence interval [CI] = 1.003 1.014), a higher genetic predisposition congenital malformations may reduce development depression OR= 0.996; %CI 0.992 0.998) effect on transient ischemic attack (IVW, P=0.004, (p=0.004, OR 4.141; 1.560 10.988). results comprehensive analyses consistent main causality estimate. No heterogeneity detected in our MR study. Conclusions Our large-scaled predispose patients while depression, particular, increases vulnerability stroke.

Language: Английский

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Progress in research of corticotropin-releasing hormone receptor 2 in inflammatory bowel disease

Shijie huaren xiaohua zazhi, Journal Year: 2024, Volume and Issue: 32(10), P. 742 - 749

Published: Oct. 28, 2024

Language: Английский

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Ginsenoside Rg1 promotes non-rapid eye movement sleep via inhibition of orexin neurons of the lateral hypothalamus and corticotropin-releasing hormone neurons of the paraventricular hypothalamic nucleus

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(6), P. 719 - 728

Published: Nov. 1, 2024

This study investigates the sleep-modulating effects of ginsenoside Rg1 (Rg1, C

Language: Английский

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