bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 16, 2024
ABSTRACT
Cardiovascular
diseases
(CVDs)
and
pathologies
are
often
driven
by
changes
in
molecular
signaling
communication,
as
well
cellular
tissue
components,
particularly
those
involving
the
extracellular
matrix
(ECM),
cytoskeleton,
immune
response.
The
fine-wire
vascular
injury
model
is
commonly
used
to
study
neointimal
hyperplasia
vessel
stiffening,
but
it
not
typically
considered
a
for
CVDs.
In
this
paper,
we
hypothesize
that
induces
gene
expression,
biological
processes
similar
observed
CVDs
at
both
transcriptome
protein
levels.
To
investigate
this,
analyzed
expression
microarray
datasets
from
injured
uninjured
femoral
arteries
mice
two
weeks
post-injury,
identifying
1,467
significantly
differentially
expressed
genes
involved
several
such
including
vaso-occlusion,
arrhythmia,
atherosclerosis.
We
further
constructed
protein-protein
interaction
network
with
seven
functionally
distinct
clusters,
notable
enrichment
ECM,
metabolic
processes,
actin-based
process,
Significant
communications
were
between
most
prominently
among
ECM
cytoskeleton
organizations,
inflammation,
cell
cycle.
Machine
Learning
Disease
pathway
analysis
revealed
injury-induced
crosstalk
remodeling
response
clusters
contributed
aortic
aneurysm,
neovascularization
of
choroid,
kidney
failure.
Additionally,
found
interactions
actin
cytoskeletal
reorganization
linked
cardiac
damage,
carotid
artery
occlusion,
lesions.
Overall,
through
multi-scale
bioinformatic
analyses,
demonstrated
robustness
eliciting
transcriptomic
associated
CVDs,
highlighting
its
potential
use
cardiovascular
research.
Cellular and Molecular Bioengineering,
Journal Year:
2024,
Volume and Issue:
17(5), P. 329 - 344
Published: Oct. 1, 2024
In
many
diseases,
an
overabundance
of
macrophages
contributes
to
adverse
outcomes.
While
numerous
studies
have
compared
macrophage
phenotype
after
mechanical
stimulation
or
with
varying
local
stiffness,
it
is
unclear
if
and
how
directly
contribute
forces
in
their
microenvironment.
Trends in Parasitology,
Journal Year:
2024,
Volume and Issue:
40(9), P. 788 - 804
Published: Aug. 23, 2024
HighlightsOxygen
and
arginine
availability,
the
tonicity
acidity
in
tissue,
have
a
major
impact
on
type
2
nitric
oxide
synthase
(NOS2)
activity
situ.Commensal
microbiota
of
skin
is
critical
for
induction
protective
immune
responses
to
Leishmania,
but
it
also
contributes
tissue
pathology,
depending
context.During
both
acute
persistent
phases
infection,
Leishmania
parasites
retreat
into
hematopoietic
as
well
non-hematopoietic
host
cells
that
function
safe
replicative
niches.AbstractLeishmania
an
intracellular
protozoan
transmitted
by
sand
fly
vectors;
causes
cutaneous,
mucocutaneous,
or
visceral
disease.
Its
growth
survival
are
impeded
1
T
helper
cell
responses,
which
entail
interferon
(IFN)-γ-mediated
macrophage
activation.
partially
escapes
this
defense
triggering
cytokine
favor
parasite
replication
rather
than
killing.
Novel
methods
situ
analyses
revealed
pathways
control
microbial
evasion
strongly
influenced
context,
micro
milieu
factors,
metabolism
at
site
we
collectively
term
'immunomicrotope'.
Understanding
components
immunomicrotope
will
enable
development
novel
strategies
treatment
chronic
leishmaniasis.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(10), P. 1017 - 1017
Published: Oct. 12, 2024
Wound
healing
is
a
complex
and
precisely
regulated
process
that
encompasses
multiple
stages,
including
inflammation,
anti-inflammation,
tissue
repair.
It
involves
various
cells
signaling
molecules,
with
macrophages
demonstrating
significant
degree
of
plasticity
playing
crucial
regulatory
role
at
different
stages.
In
recent
years,
the
use
biomaterials,
which
include
both
natural
synthetic
polymers
or
macromolecules,
has
proliferated
for
purpose
enhancing
wound
healing.
This
review
summarizes
how
these
diverse
biomaterials
promote
by
modulating
macrophage
behavior
examines
broader
implications
modulations.
Additionally,
we
discuss
limitations
associated
clinical
application
immunomodulatory
propose
potential
solutions.
Finally,
look
towards
future
developments
in
design
intended
to
enhance
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 16, 2024
ABSTRACT
Cardiovascular
diseases
(CVDs)
and
pathologies
are
often
driven
by
changes
in
molecular
signaling
communication,
as
well
cellular
tissue
components,
particularly
those
involving
the
extracellular
matrix
(ECM),
cytoskeleton,
immune
response.
The
fine-wire
vascular
injury
model
is
commonly
used
to
study
neointimal
hyperplasia
vessel
stiffening,
but
it
not
typically
considered
a
for
CVDs.
In
this
paper,
we
hypothesize
that
induces
gene
expression,
biological
processes
similar
observed
CVDs
at
both
transcriptome
protein
levels.
To
investigate
this,
analyzed
expression
microarray
datasets
from
injured
uninjured
femoral
arteries
mice
two
weeks
post-injury,
identifying
1,467
significantly
differentially
expressed
genes
involved
several
such
including
vaso-occlusion,
arrhythmia,
atherosclerosis.
We
further
constructed
protein-protein
interaction
network
with
seven
functionally
distinct
clusters,
notable
enrichment
ECM,
metabolic
processes,
actin-based
process,
Significant
communications
were
between
most
prominently
among
ECM
cytoskeleton
organizations,
inflammation,
cell
cycle.
Machine
Learning
Disease
pathway
analysis
revealed
injury-induced
crosstalk
remodeling
response
clusters
contributed
aortic
aneurysm,
neovascularization
of
choroid,
kidney
failure.
Additionally,
found
interactions
actin
cytoskeletal
reorganization
linked
cardiac
damage,
carotid
artery
occlusion,
lesions.
Overall,
through
multi-scale
bioinformatic
analyses,
demonstrated
robustness
eliciting
transcriptomic
associated
CVDs,
highlighting
its
potential
use
cardiovascular
research.
