Near-Infrared Optogenetic Nanosystem for Spatiotemporal Control of CRISPR-Cas9 Gene Editing and Synergistic Photodynamic Therapy DOI
Junyi Zeng, Xinbo Huang,

Yajie Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 701 - 710

Published: Dec. 16, 2024

Controlling CRISPR/Cas9 gene editing at the spatiotemporal resolution level, especially for in vivo applications, remains a great challenge. Here, we developed near-infrared (NIR) light-activated nanophotonic system (UCPP) controlled CRISPR-Cas9 and synergistic photodynamic therapy (PDT). Lanthanide-doped upconversion nanoparticles are not only employed as carriers intracellular plasmid delivery but also serve nanotransducers to convert NIR light (980 nm) into visible with emission 460 650 nm, which could result simultaneous activation of PDT processes, respectively. Such unique design achieves light-controlled precise hypoxia-inducible factor 1α minimal off-target effect, effectively ameliorates hypoxic state tumor sites, facilitates deep-seated process antitumor effect. This optogenetically activatable nanosystem holds potential spatially targeted cancer therapy.

Language: Английский

NIR stimulated epigallocatechin gallate loaded polydopamine with enhanced antibacterial and ROS scavenging abilities for improved infectious wound healing DOI
Jiaxi Wang, Zhiwei Gao, Hao Liang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110569 - 110569

Published: Oct. 1, 2024

Language: Английский

Citations

2
Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors DOI

ZhouXue Wu,

Junru Chen,

Biqiong Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158081 - 158081

Published: Nov. 1, 2024

Language: Английский

Citations

2
Photoresponsive Hydrogel Dressing Containing Nanoparticles with Excellent Synergetic Photodynamic, Photothermal, and Chemodynamic Therapies for Effective Infected Wound Healing DOI

Zhangjie Ge,

Hao Wu, Jianing Wu

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(10), P. 6970 - 6984

Published: Oct. 1, 2024

Bacterial resistance to antibiotics can negatively affect the treatment of infected skin wounds. The combination synergistic antibacterial therapies with photodynamic, photothermal, and chemodynamic has been recognized as one most promising approaches. In this study, we have developed MSN@Ce6@MnO

Language: Английский

Citations

1
Bacteria-Based Bioactive Materials for Tumor Immunotherapy DOI Creative Commons

Yongcan Li,

Fangfang Cao, Lie Ma

et al.

Precision medicine and engineering., Journal Year: 2024, Volume and Issue: unknown, P. 100013 - 100013

Published: Nov. 1, 2024

Language: Английский

Citations

1
Near-Infrared Optogenetic Nanosystem for Spatiotemporal Control of CRISPR-Cas9 Gene Editing and Synergistic Photodynamic Therapy DOI
Junyi Zeng, Xinbo Huang,

Yajie Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 701 - 710

Published: Dec. 16, 2024

Controlling CRISPR/Cas9 gene editing at the spatiotemporal resolution level, especially for in vivo applications, remains a great challenge. Here, we developed near-infrared (NIR) light-activated nanophotonic system (UCPP) controlled CRISPR-Cas9 and synergistic photodynamic therapy (PDT). Lanthanide-doped upconversion nanoparticles are not only employed as carriers intracellular plasmid delivery but also serve nanotransducers to convert NIR light (980 nm) into visible with emission 460 650 nm, which could result simultaneous activation of PDT processes, respectively. Such unique design achieves light-controlled precise hypoxia-inducible factor 1α minimal off-target effect, effectively ameliorates hypoxic state tumor sites, facilitates deep-seated process antitumor effect. This optogenetically activatable nanosystem holds potential spatially targeted cancer therapy.

Language: Английский

Citations

1