The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

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Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(48)

Published: Oct. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Language: Английский

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A radical eliminating and antibacterial dual-functional nanomedicine: Epigallocatechin-3-gallate-coated Prussian blue decorated polydopamine nanoparticles for wound healing

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102671 - 102671

Published: April 1, 2025

Language: Английский

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Review of light activated antibacterial nanomaterials in the second biological window

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 15, 2025

Language: Английский

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Biomimetic Polymeric Nanoreactors with Photooxidation-Initiated Therapies and Reinvigoration of Antigen-Dependent and Antigen-Free Immunity

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122884 - 122884

Published: Oct. 10, 2024

Language: Английский

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Fullerene‐Based Immunoregulatory Nanomaterials for Immunotherapy of Tumor and Immune‐Related Inflammatory Diseases

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(49)

Published: Aug. 24, 2024

Abstract Immunoregulatory strategies for activating or inhibiting immune responses have emerged as a promising approach treating tumors and immune‐related inflammatory diseases. Nanomaterials, also known their inherent immunoregulatory capacity, are extensively investigated potential in immunotherapy. Among these nanomaterials, fullerene‐based nanomaterials with unique properties attracted considerable attention use In this study, comprehensive review of the recent research progress on is presented. It illustrates specific mechanism activation using fullerene reviews applications tumor immunotherapy tumor‐enhancement Now introduces molecular over‐activated inflammation. Herein, different negative developed to inhibit Additionally, current challenges prospects developing efficient clinical usage discussed.

Language: Английский

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Targeting the tumor microenvironment with biomaterials for enhanced immunotherapeutic efficacy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 27, 2024

The tumor microenvironment (TME) is a complex system characterized by low oxygen, pH, high pressure, and numerous growth factors protein hydrolases that regulate wide range of biological behaviors in the have profound impact on cancer progression. Immunotherapy an innovative approach to treatment activates immune system, resulting spontaneous killing cells. However, therapeutic efficacy these clinically approved immunotherapies (e.g., checkpoint blocker (ICB) therapies chimeric antigen receptor (CAR) T-cell therapies) far from satisfactory due presence immunosuppressive TMEs created part hypoxia, acidity, levels reactive oxygen species (ROS), dense extracellular matrix (ECM). With continuous advances materials science drug-delivery technologies, biomaterials hold considerable potential for targeting TME. This article reviews biomaterial-based TME advance our current understanding role enhancing immunity. In addition, strategies remodeling offer enticing advantages; however, represent double-edged sword. process reshaping TME, risk growth, infiltration, distant metastasis may increase.

Language: Английский

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NIR Responsive Scaffold with Multistep Shape Memory and Photothermal-Chemodynamic Properties for Complex Tissue Defects Repair and Antibacterial Therapy

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122794 - 122794

Published: Aug. 30, 2024

Language: Английский

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Exploration of Novel Metabolic Mechanisms Underlying Primary Biliary Cholangitis Using Hepatic Metabolomics, Lipidomics, and Proteomics Analysis

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: 24(2), P. 562 - 578

Published: Jan. 10, 2025

Metabolic reprogramming is important in primary biliary cholangitis (PBC) development. However, studies investigating the metabolic signature within liver of PBC patients are limited. In this study, biopsies from 31 and 15 healthy controls were collected, comprehensive metabolomics, lipidomics, proteomics analysis conducted to characterize landscape PBC. We observed distinct lipidome remodeling with increased polyunsaturated fatty acid levels augmented β-oxidation (FAO), evidenced by acylcarnitine upregulated expression proteins involved FAO. Notably, exhibited an increase glucose-6-phosphate (G6P) purines, alongside a reduction pyruvate, suggesting impaired glycolysis purines biosynthesis Additionally, accumulation bile acids as well decrease branched chain amino aromatic liver. also aberrant upregulation associated ductular reaction, apoptosis, autophagy. conclusion, our study highlighted substantial glycolysis, metabolism, purine biosynthesis, coupled apoptosis autophagy patients. Targeting specific may offer potential targets for therapeutic intervention

Language: Английский

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Chryxanthone A, an extracted substance from endophytic fungal Aspergillus versicolor, produces anti-oxidant neuroprotection possibly via the action on mTOR/CREB axis

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149298 - 149298

Published: Jan. 1, 2025

Language: Английский

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