Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols DOI
Chengu Niu, Miaoxian Dong,

Yingcai Niu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

ABSTRACT Oxidative stress is recognized to have a central role in the initiation and progression of Parkinson's disease (PD). Within brain, neurons are particularly sensitive oxidation due part their weak intrinsic antioxidant defense. Theoretically, mostly depend on neighboring astrocytes provide protection by supplying cysteine‐containing products for glutathione (GSH) synthesis. Astrocytes possess several amino acid transport systems GSH its precursors. Indeed, most abundant nervous system. The depletion and/or alterations metabolism brain contribute pathogenesis PD. Noteworthy, polyphenols potent activity can augment redox Numerous vitro vivo studies indicated that exhibit neuroprotective effects Epidemiological found an association between consumption dietary lower PD risk. In this review, we summarize current knowledge biosynthesis with emphasis contribution therapeutic potential particular, focus increase levels against Furthermore, some challenges future perspectives polyphenol‐based therapies also discussed.

Language: Английский

Effect of lens crystallins aggregation on cataract formation DOI
Yue Wang, Kai Cao, Ziang Guo

et al.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: 253, P. 110288 - 110288

Published: Feb. 13, 2025

Language: Английский

Citations

0
Cyclic cell-penetrating peptide-engineered ceria nanoparticles for non-invasive alleviation of ultraviolet radiation-induced cataract DOI Creative Commons

Luyang Jiang,

Jinxia Liu, Silong Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 7, 2025

Oxidative stress, which results from the accumulation of free radicals, plays a substantial role in cataract formation. Antioxidants have shown promise mitigating or even preventing this process. However, delivering antioxidants noninvasively to anterior segment eye has been significant challenge. In study, we developed ceria nanoparticles modified with cyclic cell-penetrating peptides overcome obstruction dense corneal barrier on topical drug delivery. Our demonstrated that (CPPs) facilitate opening tight junctions human epithelial cells. This characteristic considerably enhances trans-corneal transport and improves cellular uptake efficiency, while also contributing their intracellular enrichment toward mitochondria. Further experiments confirmed effectively counteracted ferroptosis induced by oxidative stress lens cells both vitro vivo, substantially reducing The successful development (cCPPs) opens new avenues for research prevention treatment. Additionally, could serve as noninvasive delivery system, holds remarkable potential advancing diseases affecting eye.

Language: Английский

Citations

0
Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon? DOI Creative Commons
Jingyan Li, Francesco Buonfiglio, Ying Zeng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1249 - 1249

Published: Oct. 16, 2024

Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-induced damage lens epithelial cells (LECs). Key factors contributing cataract formation include aging, arterial hypertension, and diabetes mellitus. Given the high global prevalence cataracts, burden cataract-related visual impairment is substantial, highlighting need for pharmacological strategies supplement surgical interventions. Understanding molecular pathways involved in stress during development may offer valuable insights designing novel therapeutic approaches. This review explores role formation, focusing on critical mechanisms, such as mitochondrial dysfunction, endoplasmic reticulum stress, loss gap junctions, various cell death LECs. Additionally, we discuss emerging potential targeting options, including antioxidant-based treatments.

Language: Английский

Citations

3
Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols DOI
Chengu Niu, Miaoxian Dong,

Yingcai Niu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

ABSTRACT Oxidative stress is recognized to have a central role in the initiation and progression of Parkinson's disease (PD). Within brain, neurons are particularly sensitive oxidation due part their weak intrinsic antioxidant defense. Theoretically, mostly depend on neighboring astrocytes provide protection by supplying cysteine‐containing products for glutathione (GSH) synthesis. Astrocytes possess several amino acid transport systems GSH its precursors. Indeed, most abundant nervous system. The depletion and/or alterations metabolism brain contribute pathogenesis PD. Noteworthy, polyphenols potent activity can augment redox Numerous vitro vivo studies indicated that exhibit neuroprotective effects Epidemiological found an association between consumption dietary lower PD risk. In this review, we summarize current knowledge biosynthesis with emphasis contribution therapeutic potential particular, focus increase levels against Furthermore, some challenges future perspectives polyphenol‐based therapies also discussed.

Language: Английский

Citations

0