Some molecular-genetic determinants of premature aging in women DOI Creative Commons
Е. V. Kudryavtseva, D. A. Berezina, Daniil O. Kornilov

et al.

Consilium Medicum, Journal Year: 2024, Volume and Issue: 26(12), P. 809 - 814

Published: Dec. 18, 2024

Background. Accelerated biological aging is associated with age-related diseases and an increased risk of mortality. Genetic predisposition may be important factor in this process. Aim. To determine the significance genetic polymorphisms VDR COL1A1 genes accelerated aging. Materials methods. The study included 100 women aged 20–35 years, divided into groups (Group 1) normal/slow 2) rates. We assessed age using V.P. Voytenko's formula. analyzed were: 283 AG (Bsml), 2 (Fokl), 1546 GT, -1997 CA. Results. (AA) polymorphism was aging, occurring more frequently Group 1 (18% vs 4% 2, p=0.025). CA prevalent (76% 56% 1, p=0.035). A multifactorial model identified combinations that predict or slow accuracy 0.72. Conclusion. plays a significant role Analysis can help identify premature serve as basis for further research development new approaches to prevent diseases.

Language: Английский

3D Composite SERS Substrate Constructed by Au-Ag core-satellite NPs and Polystyrene Sphere for Ultrasensitive Ratiometric Raman Detection of Cotinine DOI
Gaofeng Wu,

Jian Zhu,

Guojun Weng

et al.

Talanta, Journal Year: 2025, Volume and Issue: 289, P. 127742 - 127742

Published: Feb. 14, 2025

Language: Английский

Citations

2
Early-life risk factors for recurrent wheezing in preschool children: A meta-analysis of 15 cohort studies DOI
Kaiwen Zheng, Xiang Wang

Allergy and Asthma Proceedings, Journal Year: 2025, Volume and Issue: 46(3), P. e98 - e109

Published: May 1, 2025

Background: Recurrent wheezing (RW) is particularly prevalent in preschool-age children and strongly associated with the future development of asthma. Objective: Because no meta-analysis risk factors for RW comprehensively assess needful. Methods: The research was conducted accordance Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. A comprehensive search English-language studies performed across four medical literature data bases. Subgroup analyses, sensitivity evaluations publication bias were carried out. Multiple cohort included. Stata software Grading Recommendations, Assessment, Development Evaluation (GRADE) used analysis; positive results discussed qualitatively. Results: total 15 that covered 128,065 Some factors, including allergic rhinitis (odds ratio [OR] 4.16 [95% confidence interval {CI}, 1.06-16.33]), family history asthma (OR 2.14 CI, 1.24-3.69]), food allergy 2.25 1.73-2.93]), preterm 1.87 1.36-2.58]), male 1.47 1.17-1.84]), cesarean section 1.36 1.08-1.71]), environmental tobacco smoke 2.15 1.55-2.99]), got results. Conclusion: Risk preschool sought. This provides a new perspective theoretical basis preventing childhood

Language: Английский

Citations

1
Smoking-attributable neurological health loss: age-specific burden and health disparities DOI
Yingjie Zhao, Fei Lu

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. jnnp - 335536

Published: Feb. 12, 2025

Background Smoking is a significant risk factor for neurological disorders, yet its global impact on these conditions remains underexplored. Methods Using Global Burden of Diseases 2021 data, we analysed trends in age-standardised disability-adjusted life-years (DALYs) and deaths attributable to smoking from 1990 three disorders: stroke, Alzheimer’s disease other dementias, Multiple Sclerosis. Socioeconomic disparities were assessed using the lope index inequality relative concentration index. Bayesian age-period-cohort models employed forecast smoking-attributable burden through 2050. Results Between 2021, annual DALYs death rates slightly declined by −1.93% −1.92%, respectively, but absolute numbers continued rise, 26.10 million 30.18 0.93 1.15 deaths. Older adults (aged 60 above) experienced greatest burden, contributing 58.15% 75.57% 2021. Smoking-attributable stroke was increasingly concentrated low sociodemographic regions, whereas dementias multiple sclerosis more pronounced socioeconomically advantaged particularly sclerosis. Conclusions This study identified an age-specific widening disorders smoking, with older disproportionately experiencing escalating impact. Targeted prevention equitable healthcare access tailored are critical mitigating health loss.

Language: Английский

Citations

0
The impact of in utero tobacco exposure on smoking behaviors, cardiovascular disease risk and all-cause mortality in adulthood: A UK Biobank study DOI Creative Commons

Yanxu Zheng,

Xinyu Xiong, Jing Bao

et al.

Current Research in Toxicology, Journal Year: 2025, Volume and Issue: 8, P. 100226 - 100226

Published: Jan. 1, 2025

Language: Английский

Citations

0
The association between biological aging markers and valvular heart diseases DOI Creative Commons

X Z Liu,

Da Luo,

Zheng Hu

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

To analyze the association between biological aging markers phenotypic age and acceleration valvular heart diseases. Research subjects met inclusion exclusion criteria were selected from UK Biobank 2006 to 2010. The calculated. of with diseases was analyzed Cox multivariate analysis, sensitivity analysis conducted by removing missing values subgroup analysis. predictive accuracy for using receiver operating characteristic (ROC) curves, a clinical decision curve generated based on logistic regression. A total 411 687 included in study, among whom there 14 258 patients overall median follow-up time 12.80 years, non-rheumatic aortic valve (n=5238), mitral (n=4558), tricuspid (n=411) 12.82 12.83 years 12.84 respectively. After adjusting demographic factors (gender, race, education, Townsend deprivation Index, Dietary Approaches Stop Hypertension score), anthropometric (body mass index), lifestyle (smoking, alcohol consumption), hypertension hyperlipidemia, showed independent risk diseases, including (phenotypic age: corrected HR=1.04, P<0.01; acceleration: HR=1.03, P<0.01), which also confirmed ROC curves that compared acceleration, had higher stronger practicality predicting diseases; single indicator, combination two indicators are Compared has greater advantage is more suitable

Language: Английский

Citations

0
Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study DOI Creative Commons
X M Shi,

YiNi Wang,

Fei Yang

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 22, 2025

Language: Английский

Citations

0
Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration DOI Creative Commons

Qiankun Yang,

Xiaoyu Zhu, Li Zhang

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 25, 2025

Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker dyslipidemia. However, whether AIP can be used as indicator aging remains unclear. This study aims investigate the relationship between US adult population. 4,471 American adults with age over 20 years National Health Nutrition Examination Survey (NHANES) database were included this study. Biological was assessed by phenotypic acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses interaction tests employed explore association PhenoAgeAccel. Furthermore, adjusted restricted cubic spline (RCS) assess potential nonlinear relationships, while mediation analysis utilized identify mediating effects homeostatic model assessment insulin resistance (HOMA-IR). Besides, network pharmacology performed determine mechanisms underlying dyslipidemia-related acceleration. A total participants study, median chronological age, PhenoAge PhenoAgeAccel for overall population 49 (35-64) years, 42.85 (27.30-59.68) - 6.92 (- 10.52 -2.46) respectively. In fully model, one unit increase correlated 1.820-year (β = 1.820, 95% CI: 1.085-2.556), which more pronounced among individuals being female, diabetic hypertensive. RCS revealed PhenoAgeAccel, inflection point identified at -0.043 via threshold saturation effect analysis. demonstrated positive correlation both before 6.550, 5.070-8.030) after 3.898, 2.474-5.322) point. Additionally, HOMA-IR found mediate 39.21% Finally, INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A, SERPINE1 core targets aging, functionally linked key signaling pathways like AMPK, apelin, JAK-STAT, FoxO, etc. CONCLUSIONS: An elevated notably positively accelerated suggesting that may serve predictor evaluate

Language: Английский

Citations

0
Early-life smoking, cardiovascular disease risk, and the mediating role of DNA methylation biomarkers of aging DOI Creative Commons

Chang Sheng,

Rui Zhou, Hongcai Wang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 29, 2025

Early-life smoking is linked to biological aging and chronic diseases, yet its specific relationship with cardiovascular disease (CVD) risk the role of DNA methylation biomarkers as potential mediators that remain underexplored. In this study, we analyzed data from 2345 participants in National Health Nutrition Examination Survey (NHANES; 1999-2002). status was assessed on basis age initiation (ASI) categorized into three periods (SIPs): childhood (5-14 years), adolescence/adulthood (> 14 never smoked. (DNAm PhenoAge, DunedinPoAm, HorvathTelo) were measured, CVD outcomes determined via self-reported, physician-confirmed diagnoses. Multivariate logistic regression causal mediation analyses performed assess associations between SIP explore mediating effects those associations. Earlier more strongly associated an increased developing CVD, showing highest (OR = 1.95, 95% CI: 1.15-3.29; P 0.013). Furthermore, independently (1-year increase DNAm PhenoAge: OR 1.03, 1.01-1.05, < 0.001; 0.1-unit DunedinPoAm: 1.19, 1.00-1.40, 0.05; 1-kb HorvathTelo: 0.57, 0.34-0.96, 0.05). Subgroup analysis revealed association early-life stronger among individuals without household exposure (P for interaction 0.035). Moreover, compared status, later correlated delayed epigenetic aging, indicated by lower PhenoAge (β=-0.02, -0.03--0.01, 0.01), slower DunedinPoAm (β=-0.01, -0.01--0.01, 0.001), longer HorvathTelo (β 0.01, 0.01-0.01, 0.001). Mediation significantly mediated risk, accounting 6% total effect (ASI: ACME=-0.000100, 0.010; SIP: ACME 0.004796, 0.022). risk. partially mediates relationship, suggesting a target prevention. these findings highlight need early prevention reduce

Language: Английский

Citations

0
Adherence to EAT-Lancet diet, biological aging and life expectancy in the UK Biobank: a cohort study DOI

Yang-Wei Cai,

Jing‐Wei Gao, Maoxiong Wu

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Serum sodium within the normal range and its U-shaped relationship with biological aging in U.S. adults DOI Creative Commons

Xianxiang Tong,

Fei Wang, Mengxue Liu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 8, 2025

This cross-sectional study evaluated the correlation between serum sodium levels (135-145 mmol/L) and biological aging in U.S. adults. Biological age, derived from multi-system biomarkers, provides a more accurate assessment of than chronological age. Hydration balance, reflected by sodium, may modulate age-related diseases mortality, but its link to remains underexplored. Using NHANES data (1999-2018), we focused on normonatremic adults (≥20 years). The final cohort included 18,301 participants. age was estimated using Klemera Doubal method, ∆age (biological age-chronological age) calculated. Associations were assessed multivariate regression, generalized additive models, threshold analysis. Subgroup analyses conducted for variations across different populations. Nonlinear analysis revealed U-shaped relationship lowest occurred at 139.3 mmol/L: each 1 mmol/L increase below this associated with reduction 0.10 years (95% CI: -0.15, -0.05), whereas values above it showed 0.08-year 0.04, 0.13). For ∆age, negative association observed 141.2 mmol/L, linked 0.07-year decrease -0.10, -0.04). significant interactions diabetic smoking Maintaining within an optimal range (138-142 help delay aging. management serve as modifiable factor healthy aging, particularly high-risk groups such individuals diabetes or tobacco use.

Language: Английский

Citations

0