Conducting Hydrogel‐Based Neural Biointerfacing Technologies

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Language: Английский

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Design Strategies and Emerging Applications of Conductive Hydrogels in Wearable Sensing

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 258 - 258

Published: April 1, 2025

Conductive hydrogels, integrating high conductivity, mechanical flexibility, and biocompatibility, have emerged as crucial materials driving the evolution of next-generation wearable sensors. Their unique ability to establish seamless interfaces with biological tissues enables real-time acquisition physiological signals, external stimuli, even therapeutic feedback, paving way for intelligent health monitoring personalized medical interventions. To fully harness their potential, significant efforts been dedicated tailoring conductive networks, properties, environmental stability these hydrogels through rational design systematic optimization. This review comprehensively summarizes strategies categorized into metal-based, carbon-based, polymer-based, ionic, hybrid systems. For each type, highlights structural principles, conductivity enhancement, approaches simultaneously enhance robustness long-term under complex environments. Furthermore, emerging applications in sensing systems are thoroughly discussed, covering signal monitoring, mechano-responsive platforms, closed-loop diagnostic–therapeutic Finally, this identifies key challenges offers future perspectives guide development multifunctional, intelligent, scalable hydrogel sensors, accelerating translation advanced flexible electronics smart healthcare technologies.

Language: Английский

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Stimuli-responsive nanoscale drug delivery system for epilepsy theranostics

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Commentary: Therapeutic Seizure Monitoring: A Closed-Loop Device for Direct Delivery of Antiseizure Therapeutics

Epiliepsy currents/Epilepsy currents, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Multifunctional hydrogel electronics for closed-loop antiepileptic treatment Qu J., Xie K., Chen S., He X., Wang Y., Chamberlin M., Zhao Zhu G., Xu C., Shi P. Sci Adv . 2024;10,(47):eadq9207. Closed-loop strategies offer advanced therapeutic potential through intelligent disease management. Here, we develop a hydrogel-based, single-component, organic electronic device neurotherapy. Fabricated out of conductive hydrogels, the consists flexible array microneedle electrodes, each which can be individually addressed to perform electrical recording and control chemical release with sophisticated spatiotemporal control, thus pioneering smart antiseizure system by combining pharmacological interventions. The recorded neural signal acts as trigger voltage-driven drug in detected pathological conditions predicted real-time electrophysiology analysis. When implanted into epileptic animals, enables autonomous management, where dosing is controlled time-sensitive, region-selective, dose-adaptive manner, allowing inhibition seizure outbursts delivery just-necessary dosages. side effects are minimized dosages three orders magnitude lower than usage approaches simulating existing clinical treatments.

Language: Английский

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Anti-Freezing Conductive Ionic Hydrogel-Enabled Triboelectric Nanogenerators for Wearable Speech Recognition

Materials, Journal Year: 2025, Volume and Issue: 18(9), P. 2014 - 2014

Published: April 29, 2025

Flexible wearable electronics face critical challenges in achieving reliable physiological monitoring, particularly due to the trade-off between sensitivity and durability flexible electrodes, compounded by mechanical modulus mismatch with biological tissues. To address these limitations, we develop an anti-freezing ionic hydrogel through a chitosan/acrylamide/LiCl system engineered via solution post-treatment strategy. The optimized exhibits exceptional conductivity (24.1 mS/cm at 25 °C) excellent cryogenic tolerance. Leveraging attributes, construct gel-based triboelectric nanogenerator (G-TENG) that demonstrates ultrahigh (1.56 V/kPa) under low pressure. device enables precise capture of subtle vibrations frequency 1088 Hz signal-to-noise ratio 16.27 dB operational stability (>16,000 cycles), successfully differentiating complex activities including swallowing, coughing, phonation. Through machine learning-assisted analysis, achieves 96.56% recognition accuracy for five words good signal ability different ambient sound scenarios. This work provides paradigm designing environmentally adaptive sensors interfacial engineering ion transport optimization.

Language: Английский

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Microfabricated Conductive PEDOT:PSS Hydrogels for Soft Electronics

Korean Journal of Chemical Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

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