Fos ensembles encode and shape stable spatial maps in the hippocampus DOI Creative Commons
Noah L. Pettit, Ee-Lynn Yap, Michael E. Greenberg

et al.

Nature, Journal Year: 2022, Volume and Issue: 609(7926), P. 327 - 334

Published: Aug. 24, 2022

Abstract In the hippocampus, spatial maps are formed by place cells while contextual memories thought to be encoded as engrams 1–6 . Engrams typically identified expression of immediate early gene Fos , but little is known about neural activity patterns that drive, and shaped by, in behaving animals 7–10 Thus, it unclear whether Fos-expressing hippocampal neurons also encode correlates with affects specific features code 11 Here we measured CA1 calcium imaging monitoring induction mice performing a hippocampus-dependent learning task virtual reality. We find high form ensembles highly correlated activity, exhibit reliable fields evenly tile environment have more stable tuning across days than nearby non-Fos-induced cells. Comparing neighbouring without function using sparse genetic loss-of-function approach, disrupted less decreased selectivity lower across-day stability. Our results demonstrate Fos-induced contribute codes encoding accurate, spatially uniform itself has causal role shaping these codes. may therefore link two key aspects function: for underlie cognitive maps.

Language: Английский

Illuminating dendritic function with computational models DOI
Panayiota Poirazi, Athanasia Papoutsi

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(6), P. 303 - 321

Published: May 11, 2020

Language: Английский

Citations

250
Neural Circuit Motifs in Valence Processing DOI Creative Commons
Kay M. Tye

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 436 - 452

Published: Oct. 1, 2018

Language: Английский

Citations

223
Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior DOI Creative Commons

Nick T.M. Robinson,

Lucie A.L. Descamps, Lloyd Russell

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(6), P. 1586 - 1599.e10

Published: Nov. 6, 2020

The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment have been proposed to form the neural basis of a cognitive map space that supports these mnemonic functions. However, direct influence cell on behavior has not yet demonstrated. Using 'all-optical' combination simultaneous two-photon calcium imaging optogenetics, we identified selectively activated encoded behaviorally relevant locations in virtual reality environment. Targeted stimulation small number was sufficient bias animals during task, providing causal evidence hippocampal actively support memory.

Language: Английский

Citations

221
Increased Prevalence of Calcium Transients across the Dendritic Arbor during Place Field Formation DOI Creative Commons
Mark Sheffield,

Michael D. Adoff,

Daniel A. Dombeck

et al.

Neuron, Journal Year: 2017, Volume and Issue: 96(2), P. 490 - 504.e5

Published: Oct. 1, 2017

Language: Английский

Citations

206
The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales DOI Creative Commons
William Mau, David W. Sullivan, Nathaniel R. Kinsky

et al.

Current Biology, Journal Year: 2018, Volume and Issue: 28(10), P. 1499 - 1508.e4

Published: April 26, 2018

Language: Английский

Citations

205
Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future DOI Creative Commons
Zuzanna Brzosko, Susanna B. Mierau, Ole Paulsen

et al.

Neuron, Journal Year: 2019, Volume and Issue: 103(4), P. 563 - 581

Published: Aug. 1, 2019

Language: Английский

Citations

202
Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits DOI
Alexandre Payeur, Jordan Guerguiev, Friedemann Zenke

et al.

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(7), P. 1010 - 1019

Published: May 13, 2021

Language: Английский

Citations

201
Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning DOI Creative Commons
Gergely F. Turi, Wenke Li, Spyridon Chavlis

et al.

Neuron, Journal Year: 2019, Volume and Issue: 101(6), P. 1150 - 1165.e8

Published: Feb. 1, 2019

Language: Английский

Citations

194
A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning DOI Creative Commons

Alexandra M. Kaufman,

Tristan Geiller, Attila Losonczy

et al.

Neuron, Journal Year: 2020, Volume and Issue: 105(6), P. 1018 - 1026.e4

Published: Jan. 21, 2020

Language: Английский

Citations

178
Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output DOI Creative Commons

Matt Udakis,

Victor Pedrosa,

Sophie E.L. Chamberlain

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 2, 2020

Abstract The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns inhibition from diverse interneuron populations. Although it known that inhibitory synaptic strength malleable, induction long-term plasticity at distinct synapses its regulation network activity not well understood. Here, we show parvalbumin somatostatin expressing interneurons undergo depression potentiation respectively (PV-iLTD SST-iLTP) during physiological patterns. Both forms rely on T-type calcium channel activation to confer synapse specificity but otherwise employ mechanisms. Since preferentially target perisomatic distal dendritic regions CA1 pyramidal cells, PV-iLTD SST-iLTP coordinate a reprioritisation excitatory inputs entorhinal cortex CA3. Furthermore, circuit-level modelling reveals cooperate stabilise place cells while facilitating representation multiple unique environments the network.

Language: Английский

Citations

165