DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

Nature, Journal Year: 2020, Volume and Issue: 583(7814), P. 133 - 138

Published: June 11, 2020

Language: Английский

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The matrix in cancer

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(4), P. 217 - 238

Published: Feb. 15, 2021

Language: Английский

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Circulating tumor cells: biology and clinical significance

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Nov. 22, 2021

Abstract Circulating tumor cells (CTCs) are that have sloughed off the primary and extravasate into circulate in blood. Understanding of metastatic cascade CTCs has tremendous potential for identification targets against cancer metastasis. Detecting these very rare among massive blood is challenging. However, emerging technologies detection profoundly contributed to deepening investigation biology facilitated their clinical application. Current summarized herein, together with advantages disadvantages. The usually dependent on molecular markers, epithelial cell adhesion molecule being most widely used, although markers vary between different types cancer. Properties associated epithelial-to-mesenchymal transition stemness been identified CTCs, indicating increased capacity. Only a small proportion can survive eventually initiate metastases, suggesting an interaction modulation hostile microenvironment essential CTC Single-cell sequencing extensively investigated, enabled researchers reveal genome transcriptome CTCs. Herein, we also review applications especially monitoring response treatment evaluating prognosis. Hence, will continue contribute providing significant insights processes open new avenues useful applications.

Language: Английский

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Defining the Hallmarks of Metastasis

Cancer Research, Journal Year: 2019, Volume and Issue: 79(12), P. 3011 - 3027

Published: May 3, 2019

Abstract Metastasis is the primary cause of cancer morbidity and mortality. The process involves a complex interplay between intrinsic tumor cell properties as well interactions cells multiple microenvironments. outcome development nearby or distant discontiguous secondary mass. To successfully disseminate, metastatic acquire in addition to those necessary become neoplastic. Heterogeneity mechanisms involved, routes dissemination, redundancy molecular pathways that can be utilized, ability piggyback on actions surrounding stromal makes defining hallmarks metastasis extraordinarily challenging. Nonetheless, this review identifies four distinguishing features are required: motility invasion, modulate site local microenvironments, plasticity, colonize tissues. By these first principles metastasis, we provide means for focusing efforts aspects will improve patient outcomes.

Language: Английский

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Neutrophils as emerging therapeutic targets

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(4), P. 253 - 275

Published: Jan. 22, 2020

Language: Английский

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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

Immunity, Journal Year: 2020, Volume and Issue: 52(5), P. 856 - 871.e8

Published: April 13, 2020

Language: Английский

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Cancer Stem Cells: The Architects of the Tumor Ecosystem

Cell stem cell, Journal Year: 2019, Volume and Issue: 24(1), P. 41 - 53

Published: Jan. 1, 2019

Language: Английский

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Neutrophils in cancer: heterogeneous and multifaceted

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(3), P. 173 - 187

Published: July 6, 2021

Language: Английский

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The Extracellular Matrix Modulates the Metastatic Journey

Developmental Cell, Journal Year: 2019, Volume and Issue: 49(3), P. 332 - 346

Published: May 1, 2019

Language: Английский

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Tumor Immunology and Tumor Evolution: Intertwined Histories

Immunity, Journal Year: 2020, Volume and Issue: 52(1), P. 55 - 81

Published: Jan. 1, 2020

Language: Английский

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