Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Dec. 3, 2020
Abstract
The
implementation
of
continuous
flow
technology
is
critical
towards
enhancing
the
application
photochemical
reactions
for
industrial
process
development.
However,
there
are
significant
time
and
resource
constraints
associated
with
translating
discovery
scale
vial-based
batch
to
scale-up
conditions.
Herein
we
report
development
a
droplet
microfluidic
platform,
which
enables
high-throughput
reaction
in
generate
pharmaceutically
relevant
compound
libraries.
This
platform
allows
enhanced
material
efficiency,
as
can
be
performed
on
picomole
scale.
Furthermore,
data
collection
via
on-line
ESI
mass
spectrometry
facilitates
rapid
analysis
individual,
nanoliter-sized
droplets
at
acquisition
rates
0.3
samples/s.
We
envision
this
screening
expand
upon
robust
capabilities
impact
drug
Science,
Journal Year:
2019,
Volume and Issue:
365(6453)
Published: Aug. 8, 2019
Pairing
prediction
and
robotic
synthesis
Progress
in
automated
of
organic
compounds
has
been
proceeding
along
parallel
tracks.
One
goal
is
algorithmic
viable
routes
to
a
desired
compound;
the
other
implementation
known
reaction
sequence
on
platform
that
needs
little
no
human
intervention.
Coley
et
al.
now
report
preliminary
integration
these
two
protocols.
They
paired
retrosynthesis
algorithm
with
robotically
reconfigurable
flow
apparatus.
Human
intervention
was
still
required
supplement
predictor
practical
considerations
such
as
solvent
choice
precise
stoichiometry,
although
predictions
should
improve
accessible
data
accumulate
for
training.
Science
,
this
issue
p.
eaax1566
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2752 - 2906
Published: Aug. 10, 2021
Photoinduced
chemical
transformations
have
received
in
recent
years
a
tremendous
amount
of
attention,
providing
plethora
opportunities
to
synthetic
organic
chemists.
However,
performing
photochemical
transformation
can
be
quite
challenge
because
various
issues
related
the
delivery
photons.
These
challenges
barred
widespread
adoption
steps
industry.
past
decade,
several
technological
innovations
led
more
reproducible,
selective,
and
scalable
photoinduced
reactions.
Herein,
we
provide
comprehensive
overview
these
exciting
advances,
including
flow
chemistry,
high-throughput
experimentation,
reactor
design
scale-up,
combination
photo-
electro-chemistry.
Science,
Journal Year:
2018,
Volume and Issue:
363(6423)
Published: Nov. 30, 2018
The
synthesis
of
complex
organic
compounds
is
largely
a
manual
process
that
often
incompletely
documented.
To
address
these
shortcomings,
we
developed
an
abstraction
maps
commonly
reported
methodological
instructions
into
discrete
steps
amenable
to
automation.
These
unit
operations
were
implemented
in
modular
robotic
platform
by
using
chemical
programming
language
formalizes
and
controls
the
assembly
molecules.
We
validated
concept
directing
automated
system
synthesize
three
pharmaceutical
compounds,
diphenhydramine
hydrochloride,
rufinamide,
sildenafil,
without
any
human
intervention.
Yields
purities
products
intermediates
comparable
or
better
than
those
achieved
manually.
syntheses
are
captured
as
digital
code
can
be
published,
versioned,
transferred
flexibly
between
platforms
with
no
modification,
thereby
greatly
enhancing
reproducibility
reliable
access
Journal of Hematology & Oncology,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: Feb. 12, 2021
Mesenchymal
stromal
cells
(MSCs),
also
known
as
mesenchymal
stem
cells,
have
been
intensely
investigated
for
clinical
applications
within
the
last
decades.
However,
majority
of
registered
trials
applying
MSC
therapy
diverse
human
diseases
fallen
short
expectations,
despite
encouraging
pre-clinical
outcomes
in
varied
animal
disease
models.
This
can
be
attributable
to
inconsistent
criteria
MSCs
identity
across
studies
and
their
inherited
heterogeneity.
Nowadays,
with
emergence
advanced
biological
techniques
substantial
improvements
bio-engineered
materials,
strategies
developed
overcome
challenges
application.
Here
this
review,
we
will
discuss
major
therapies
application,
factors
impacting
diversity
MSCs,
potential
approaches
that
modify
products
highest
therapeutic
potential,
finally
usage
COVID-19
pandemic
disease.
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
120(15), P. 7219 - 7347
Published: July 15, 2020
The
ever
increasing
industrial
production
of
commodity
and
specialty
chemicals
inexorably
depletes
the
finite
primary
fossil
resources
available
on
Earth.
forecast
population
growth
over
next
3
decades
is
a
very
strong
incentive
for
identification
alternative
other
than
petro-based
ones.
In
contrast
with
resources,
renewable
biomass
virtually
inexhaustible
reservoir
chemical
building
blocks.
Shifting
current
paradigm
from
almost
exclusively
to
bio-based
raw
materials
requires
more
vibrant
political
messages;
it
profound
revision
concepts
technologies
which
processes
rely.
Only
small
fraction
molecules
extracted
bears
significant
commercial
potentials
be
considered
as
ubiquitous
platforms
upon
new,
industry
can
thrive.
Owing
its
inherent
assets
in
terms
unique
process
experience,
scalability,
reduced
environmental
footprint,
flow
chemistry
arguably
has
major
role
play
this
context.
This
review
covers
selection
C2
C6
existing
markets
including
polyols
(ethylene
glycol,
1,2-propanediol,
1,3-propanediol,
glycerol,
1,4-butanediol,
xylitol,
sorbitol),
furanoids
(furfural
5-hydroxymethylfurfural)
carboxylic
acids
(lactic
acid,
succinic
fumaric
malic
itaconic
levulinic
acid).
aim
illustrate
various
aspects
upgrading
platform
toward
or
using
new
that
fall
under
umbrella
continuous
technology
could
change
future
perspectives
biorefineries.
