Nature, Journal Year: 2020, Volume and Issue: 586(7827), P. 133 - 138
Published: July 29, 2020
Language: Английский
Nature, Journal Year: 2020, Volume and Issue: 586(7827), P. 133 - 138
Published: July 29, 2020
Language: Английский
Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 243 - 278
Published: Jan. 1, 2023
Language: Английский
Citations
2975Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(10), P. 555 - 572
Published: Aug. 10, 2020
Language: Английский
Citations
1021Nature, Journal Year: 2020, Volume and Issue: 578(7793), P. 122 - 128
Published: Feb. 5, 2020
Cancer develops through a process of somatic evolution
Language: Английский
Citations
921Science, Journal Year: 2019, Volume and Issue: 366(6465)
Published: Oct. 31, 2019
As people age, their tissues accumulate an increasing number of somatic mutations. Although most these mutations are little or no functional consequence, a mutation may arise that confers fitness advantage on cell. When this process happens in the hematopoietic system, substantial proportion circulating blood cells derive from single mutated stem This outgrowth, called "clonal hematopoiesis," is highly prevalent elderly population. Here we discuss recent advances our knowledge clonal hematopoiesis, its relationship to malignancies, link nonmalignant diseases aging, and potential impact immune function. Clonal hematopoiesis provides glimpse into selection likely occurs all tissues.
Language: Английский
Citations
862Genome biology, Journal Year: 2019, Volume and Issue: 20(1)
Published: Nov. 25, 2019
Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These are acknowledged as highly accurate molecular correlate chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates test longevity or rejuvenating interventions. Here, we discuss key challenges understand clock mechanisms biomarker utility. This requires dissecting the drivers regulators age-related changes single-cell, tissue- disease-specific models, well exploring epigenomic marks, longitudinal diverse population studies, non-human models. We also highlight important ethical issues forensic determination predicting trajectory an individual.
Language: Английский
Citations
796Nature, Journal Year: 2019, Volume and Issue: 574(7779), P. 532 - 537
Published: Oct. 23, 2019
Language: Английский
Citations
628Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(8), P. 471 - 480
Published: May 13, 2020
Language: Английский
Citations
613Nature Genetics, Journal Year: 2020, Volume and Issue: 52(11), P. 1219 - 1226
Published: Oct. 26, 2020
Language: Английский
Citations
566Science, Journal Year: 2019, Volume and Issue: 364(6444)
Published: June 6, 2019
How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 tissues revealed multiple variants, demonstrating that macroscopic clones can be found many tissues. We sun-exposed skin, esophagus, and lung have a higher mutation burden than other tested tissues, which suggests environmental factors promote mosaicism. Mutation was associated with both age tissue-specific cell proliferation rate, highlighting over time number divisions. Finally, were to harbor known cancer genes hotspots. This study provides broad view clonal expansion human thus serving as foundation for associating factors, aging, risk disease.
Language: Английский
Citations
444Nature, Journal Year: 2020, Volume and Issue: 578(7794), P. 266 - 272
Published: Jan. 29, 2020
Language: Английский
Citations
441