The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic DOI

Eliran Kadosh,

Irit Snir-Alkalay,

Avanthika Venkatachalam

et al.

Nature, Journal Year: 2020, Volume and Issue: 586(7827), P. 133 - 138

Published: July 29, 2020

Language: Английский

Hallmarks of aging: An expanding universe DOI Creative Commons
Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 243 - 278

Published: Jan. 1, 2023

Language: Английский

Citations

2975

A compendium of mutational cancer driver genes DOI
Francisco Martínez-Jiménez, Ferran Muiños, Inés Sentís

et al.

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(10), P. 555 - 572

Published: Aug. 10, 2020

Language: Английский

Citations

1021

The evolutionary history of 2,658 cancers DOI Creative Commons
Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner

et al.

Nature, Journal Year: 2020, Volume and Issue: 578(7793), P. 122 - 128

Published: Feb. 5, 2020

Cancer develops through a process of somatic evolution

Language: Английский

Citations

921

Clonal hematopoiesis in human aging and disease DOI Open Access
Siddhartha Jaiswal, Benjamin L. Ebert

Science, Journal Year: 2019, Volume and Issue: 366(6465)

Published: Oct. 31, 2019

As people age, their tissues accumulate an increasing number of somatic mutations. Although most these mutations are little or no functional consequence, a mutation may arise that confers fitness advantage on cell. When this process happens in the hematopoietic system, substantial proportion circulating blood cells derive from single mutated stem This outgrowth, called "clonal hematopoiesis," is highly prevalent elderly population. Here we discuss recent advances our knowledge clonal hematopoiesis, its relationship to malignancies, link nonmalignant diseases aging, and potential impact immune function. Clonal hematopoiesis provides glimpse into selection likely occurs all tissues.

Language: Английский

Citations

862

DNA methylation aging clocks: challenges and recommendations DOI Creative Commons
Christopher G. Bell, Robert Lowe, Peter D. Adams

et al.

Genome biology, Journal Year: 2019, Volume and Issue: 20(1)

Published: Nov. 25, 2019

Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These are acknowledged as highly accurate molecular correlate chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates test longevity or rejuvenating interventions. Here, we discuss key challenges understand clock mechanisms biomarker utility. This requires dissecting the drivers regulators age-related changes single-cell, tissue- disease-specific models, well exploring epigenomic marks, longitudinal diverse population studies, non-human models. We also highlight important ethical issues forensic determination predicting trajectory an individual.

Language: Английский

Citations

796

The landscape of somatic mutation in normal colorectal epithelial cells DOI
Henry Lee-Six, Sigurgeir Ólafsson, Peter Ellis

et al.

Nature, Journal Year: 2019, Volume and Issue: 574(7779), P. 532 - 537

Published: Oct. 23, 2019

Language: Английский

Citations

628

p53: 800 million years of evolution and 40 years of discovery DOI
Arnold J. Levine

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(8), P. 471 - 480

Published: May 13, 2020

Language: Английский

Citations

613

Cancer therapy shapes the fitness landscape of clonal hematopoiesis DOI
Kelly L. Bolton, Ryan Ptashkin, Teng Gao

et al.

Nature Genetics, Journal Year: 2020, Volume and Issue: 52(11), P. 1219 - 1226

Published: Oct. 26, 2020

Language: Английский

Citations

566

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues DOI Open Access
Keren Yizhak, François Aguet, Jaegil Kim

et al.

Science, Journal Year: 2019, Volume and Issue: 364(6444)

Published: June 6, 2019

How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 tissues revealed multiple variants, demonstrating that macroscopic clones can be found many tissues. We sun-exposed skin, esophagus, and lung have a higher mutation burden than other tested tissues, which suggests environmental factors promote mosaicism. Mutation was associated with both age tissue-specific cell proliferation rate, highlighting over time number divisions. Finally, were to harbor known cancer genes hotspots. This study provides broad view clonal expansion human thus serving as foundation for associating factors, aging, risk disease.

Language: Английский

Citations

444

Tobacco smoking and somatic mutations in human bronchial epithelium DOI
Kenichi Yoshida, Kate H.C. Gowers, Henry Lee-Six

et al.

Nature, Journal Year: 2020, Volume and Issue: 578(7794), P. 266 - 272

Published: Jan. 29, 2020

Language: Английский

Citations

441