Hallmarks of aging: An expanding universe

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 243 - 278

Published: Jan. 1, 2023

Language: Английский

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A compendium of mutational cancer driver genes

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(10), P. 555 - 572

Published: Aug. 10, 2020

Language: Английский

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The evolutionary history of 2,658 cancers

Nature, Journal Year: 2020, Volume and Issue: 578(7793), P. 122 - 128

Published: Feb. 5, 2020

Cancer develops through a process of somatic evolution

Language: Английский

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Clonal hematopoiesis in human aging and disease

Science, Journal Year: 2019, Volume and Issue: 366(6465)

Published: Oct. 31, 2019

As people age, their tissues accumulate an increasing number of somatic mutations. Although most these mutations are little or no functional consequence, a mutation may arise that confers fitness advantage on cell. When this process happens in the hematopoietic system, substantial proportion circulating blood cells derive from single mutated stem This outgrowth, called "clonal hematopoiesis," is highly prevalent elderly population. Here we discuss recent advances our knowledge clonal hematopoiesis, its relationship to malignancies, link nonmalignant diseases aging, and potential impact immune function. Clonal hematopoiesis provides glimpse into selection likely occurs all tissues.

Language: Английский

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DNA methylation aging clocks: challenges and recommendations

Genome biology, Journal Year: 2019, Volume and Issue: 20(1)

Published: Nov. 25, 2019

Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These are acknowledged as highly accurate molecular correlate chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates test longevity or rejuvenating interventions. Here, we discuss key challenges understand clock mechanisms biomarker utility. This requires dissecting the drivers regulators age-related changes single-cell, tissue- disease-specific models, well exploring epigenomic marks, longitudinal diverse population studies, non-human models. We also highlight important ethical issues forensic determination predicting trajectory an individual.

Language: Английский

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The landscape of somatic mutation in normal colorectal epithelial cells

Nature, Journal Year: 2019, Volume and Issue: 574(7779), P. 532 - 537

Published: Oct. 23, 2019

Language: Английский

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p53: 800 million years of evolution and 40 years of discovery

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(8), P. 471 - 480

Published: May 13, 2020

Language: Английский

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Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Nature Genetics, Journal Year: 2020, Volume and Issue: 52(11), P. 1219 - 1226

Published: Oct. 26, 2020

Language: Английский

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RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Science, Journal Year: 2019, Volume and Issue: 364(6444)

Published: June 6, 2019

How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 tissues revealed multiple variants, demonstrating that macroscopic clones can be found many tissues. We sun-exposed skin, esophagus, and lung have a higher mutation burden than other tested tissues, which suggests environmental factors promote mosaicism. Mutation was associated with both age tissue-specific cell proliferation rate, highlighting over time number divisions. Finally, were to harbor known cancer genes hotspots. This study provides broad view clonal expansion human thus serving as foundation for associating factors, aging, risk disease.

Language: Английский

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Tobacco smoking and somatic mutations in human bronchial epithelium

Nature, Journal Year: 2020, Volume and Issue: 578(7794), P. 266 - 272

Published: Jan. 29, 2020

Language: Английский

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