Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: March 22, 2022
Abstract
A
major
debate
about
the
neural
correlates
of
conscious
perception
concerns
its
cortical
organization,
namely,
whether
it
includes
prefrontal
cortex
(PFC),
which
mediates
executive
functions,
or
is
constrained
within
posterior
cortices.
It
has
been
suggested
that
PFC
activity
during
paradigms
investigating
conflated
with
post-perceptual
processes
associated
reporting
contents
consciousness
feedforward
signals
originating
from
exogenous
stimulus
manipulations
and
relayed
via
areas.
We
addressed
this
by
simultaneously
probing
neuronal
populations
in
rhesus
macaque
(Macaca
mulatta)
a
no-report
paradigm,
capable
instigating
internally
generated
transitions
perception,
without
changes
visual
stimulation.
find
feature-selective
neurons
are
modulated
concomitantly
subjective
perceptual
suppression
their
preferred
both
externally
induced
perception.
Importantly,
enables
reliable
single-trial,
population
decoding
contents.
Control
experiments
confirm
significant
contents,
even
when
oculomotor
responses,
used
for
inferring
suppressed.
These
findings
suggest
reliably
reflected
absence
volitional
reports
sensory
input.
Annual Review of Neuroscience,
Journal Year:
2020,
Volume and Issue:
43(1), P. 249 - 275
Published: July 8, 2020
Significant
experimental,
computational,
and
theoretical
work
has
identified
rich
structure
within
the
coordinated
activity
of
interconnected
neural
populations.
An
emerging
challenge
now
is
to
uncover
nature
associated
computations,
how
they
are
implemented,
what
role
play
in
driving
behavior.
We
term
this
computation
through
population
dynamics.
If
successful,
framework
will
reveal
general
motifs
quantitatively
describe
dynamics
implement
computations
necessary
for
goal-directed
Here,
we
start
with
a
mathematical
primer
on
dynamical
systems
theory
analytical
tools
apply
perspective
experimental
data.
Next,
highlight
some
recent
discoveries
resulting
from
successful
application
systems.
focus
studies
spanning
motor
control,
timing,
decision-making,
working
memory.
Finally,
briefly
discuss
promising
lines
investigation
future
directions
framework.
Cell,
Journal Year:
2020,
Volume and Issue:
183(6), P. 1586 - 1599.e10
Published: Nov. 6, 2020
The
hippocampus
is
crucial
for
spatial
navigation
and
episodic
memory
formation.
Hippocampal
place
cells
exhibit
spatially
selective
activity
within
an
environment
have
been
proposed
to
form
the
neural
basis
of
a
cognitive
map
space
that
supports
these
mnemonic
functions.
However,
direct
influence
cell
on
behavior
has
not
yet
demonstrated.
Using
'all-optical'
combination
simultaneous
two-photon
calcium
imaging
optogenetics,
we
identified
selectively
activated
encoded
behaviorally
relevant
locations
in
virtual
reality
environment.
Targeted
stimulation
small
number
was
sufficient
bias
animals
during
task,
providing
causal
evidence
hippocampal
actively
support
memory.
Nature,
Journal Year:
2023,
Volume and Issue:
615(7951), P. 292 - 299
Published: March 1, 2023
Abstract
Emotional
states
influence
bodily
physiology,
as
exemplified
in
the
top-down
process
by
which
anxiety
causes
faster
beating
of
heart
1–3
.
However,
whether
an
increased
rate
might
itself
induce
or
fear
responses
is
unclear
3–8
Physiological
theories
emotion,
proposed
over
a
century
ago,
have
considered
that
general,
there
could
be
important
and
even
dominant
flow
information
from
body
to
brain
9
Here,
formally
test
this
idea,
we
developed
noninvasive
optogenetic
pacemaker
for
precise,
cell-type-specific
control
cardiac
rhythms
up
900
beats
per
minute
freely
moving
mice,
enabled
wearable
micro-LED
harness
systemic
viral
delivery
potent
pump-like
channelrhodopsin.
We
found
optically
evoked
tachycardia
potently
enhanced
anxiety-like
behaviour,
but
crucially
only
risky
contexts,
indicating
both
central
(brain)
peripheral
(body)
processes
may
involved
development
emotional
states.
To
identify
potential
mechanisms,
used
whole-brain
activity
screening
electrophysiology
find
regions
were
activated
imposed
rhythms.
identified
posterior
insular
cortex
mediator
bottom-up
interoceptive
processing,
inhibition
region
attenuated
behaviour
was
induced
optical
pacing.
Together,
these
findings
reveal
cells
must
together
understand
origins
affective
More
broadly,
our
results
define
generalizable
approach
noninvasive,
temporally
precise
functional
investigations
joint
organism-wide
interactions
among
targeted
during
behaviour.
