FEBS Letters,
Journal Year:
2022,
Volume and Issue:
596(7), P. 849 - 875
Published: March 9, 2022
Systemic
inflammation
is
associated
with
chronic
disease
and
purported
to
be
a
main
pathogenic
mechanism
underlying
metabolic
conditions.
Microbes
harbored
in
the
host
gastrointestinal
tract
release
signaling
byproducts
from
their
cell
wall,
such
as
lipopolysaccharides
(LPS),
which
can
act
locally
and,
after
crossing
gut
barrier
entering
circulation,
also
systemically.
Defined
endotoxemia,
elevated
concentrations
of
LPS
circulation
are
conditions
disease.
As
such,
measurement
highly
prevalent
animal
human
research
investigating
these
states.
Indeed,
potent
stimulant
immunity,
but
this
response
depends
on
microbial
species’
origin,
parameter
often
overlooked
both
preclinical
clinical
investigations.
lipid
A
portion
mutable
comprises
virulence
endotoxic
component,
thus
contributing
structural
functional
diversity
among
LPSs
species.
In
review,
we
discuss
how
differences
induce
differential
immunological
responses
host.
Science,
Journal Year:
2022,
Volume and Issue:
376(6596), P. 940 - 945
Published: May 26, 2022
Human
skin
forms
a
protective
barrier
against
the
external
environment
and
is
our
first
line
of
defense
toxic,
solar,
pathogenic
insults.
Our
also
defines
outward
appearance,
protects
internal
tissues
organs,
acts
as
sensory
interface,
prevents
dehydration.
Crucial
to
skin's
function
colonizing
microbiota,
which
provides
protection
pathogens,
tunes
immune
responses,
fortifies
epithelium.
Here
we
highlight
recent
advances
in
understanding
how
microbiota
mediates
multiple
facets
function.
We
discuss
insights
into
pathological
host-microbiota
interactions
implications
for
disorders
distant
organs.
Finally,
examine
microbiota-based
mechanisms
can
be
targeted
prevent
or
manage
impaired
wound
healing.
European Journal of Immunology,
Journal Year:
2021,
Volume and Issue:
51(12), P. 2708 - 3145
Published: Dec. 1, 2021
Abstract
The
third
edition
of
Flow
Cytometry
Guidelines
provides
the
key
aspects
to
consider
when
performing
flow
cytometry
experiments
and
includes
comprehensive
sections
describing
phenotypes
functional
assays
all
major
human
murine
immune
cell
subsets.
Notably,
contain
helpful
tables
highlighting
differences
between
cells.
Another
useful
feature
this
is
analysis
clinical
samples
with
examples
applications
in
context
autoimmune
diseases,
cancers
as
well
acute
chronic
infectious
diseases.
Furthermore,
there
are
detailing
tips,
tricks
pitfalls
avoid.
All
written
peer‐reviewed
by
leading
experts
immunologists,
making
an
essential
state‐of‐the‐art
handbook
for
basic
researchers.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
Mucosal Immunology,
Journal Year:
2021,
Volume and Issue:
14(2), P. 296 - 304
Published: Jan. 26, 2021
Bacteria
that
colonize
the
human
gastrointestinal
tract
are
essential
for
good
health.
The
gut
microbiota
has
a
critical
role
in
pulmonary
immunity
and
host's
defense
against
viral
respiratory
infections.
microbiota's
composition
function
can
be
profoundly
affected
many
disease
settings,
including
acute
infections,
these
changes
aggravate
severity
of
disease.
Here,
we
discuss
mechanisms
by
which
arms
lung
to
control
We
summarize
impact
infections
on
potential
leading
alterations
functions.
also
effects
microbial
imbalance
outcomes,
disorders
secondary
bacterial
Lastly,
lung–gut
axis
coronavirus
2019.
Mucosal Immunology,
Journal Year:
2020,
Volume and Issue:
13(2), P. 183 - 189
Published: Jan. 27, 2020
The
ontogeny
and
maturation
of
the
immune
system
is
modulated
by
microbiota.
During
fetal
life,
mother's
microbiota
produces
compounds
that
are
transferred
to
fetus
offspring,
enhance
generation
innate
cells.
After
birth,
colonizing
induces
development
intestinal
lymphoid
tissues
myeloid
cells,
imprints
with
a
reactivity
level
persists
long
after
weaning
into
adulthood.
When
cross-talk
between
host
perturbed
early
in
pathological
imprinting
may
develop
characterized
excessive
adulthood,
which
translates
increased
susceptibility
inflammatory
pathologies.
In
this
review,
we
discuss
recent
data
demonstrate
existence
time
window
opportunity
life
during
mice
human
have
be
exposed
order
balanced
system.
We
also
factors
involved
imprinting,
such
as
microbiota,
cells
stromal
well
nature
imprinting.
Annual Review of Immunology,
Journal Year:
2021,
Volume and Issue:
39(1), P. 449 - 479
Published: April 26, 2021
The
immune
system
has
coevolved
with
extensive
microbial
communities
living
on
barrier
sites
that
are
collectively
known
as
the
microbiota.
It
is
increasingly
clear
antigens
and
metabolites
engage
in
a
constant
dialogue
system,
leading
to
microbiota-specific
responses
occur
absence
of
inflammation.
This
form
homeostatic
immunity
encompasses
many
arms
immunity,
including
B
cell
responses,
innate-like
T
cells,
conventional
helper
regulatory
responses.
In
this
review
we
summarize
examples
adaptive
microbiota,
focusing
fundamental
aspects
commensal
recognition
across
different
sites.
Furthermore,
explore
how
cross
talk
established
during
development,
emphasizing
critical
temporal
windows
establish
long-term
function.
Finally,
highlight
dysregulation
microbiota
can
lead
inflammation
disease,
pinpoint
outstanding
questions
controversies
regarding
system–microbiota
interactions.
Nature Immunology,
Journal Year:
2021,
Volume and Issue:
22(3), P. 322 - 335
Published: Feb. 2, 2021
Immune
system
dysfunction
is
paramount
in
coronavirus
disease
2019
(COVID-19)
severity
and
fatality
rate.
Mucosal-associated
invariant
T
(MAIT)
cells
are
innate-like
involved
mucosal
immunity
protection
against
viral
infections.
Here,
we
studied
the
immune
cell
landscape,
with
emphasis
on
MAIT
cells,
cohorts
totaling
208
patients
various
stages
of
disease.
frequency
strongly
reduced
blood.
They
display
a
strong
activated
cytotoxic
phenotype
that
more
pronounced
lungs.
Blood
alterations
positively
correlate
activation
other
innate
proinflammatory
cytokines,
notably
interleukin
(IL)-18,
mortality
severe
acute
respiratory
syndrome
2
infection.
We
also
identified
monocyte/macrophage
interferon
(IFN)-α–IL-18
cytokine
shift
ability
infected
macrophages
to
induce
cytotoxicity
an
MR1-dependent
manner.
Together,
our
results
suggest
altered
functions
due
IFN-α–IL-18
imbalance
contribute
severity,
their
therapeutic
manipulation
may
prevent
deleterious
inflammation
COVID-19
aggravation.
Severe
characterized
by
hyperinflammation,
there
need
for
accurate
predictive
biomarkers
progression.
Lehuen
et
al.
demonstrate
show
dramatic
loss
those
do
remain
highly
state.
