Current Biology, Journal Year: 2021, Volume and Issue: 31(23), P. 5350 - 5363.e5
Published: Oct. 12, 2021
Language: Английский
Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(2), P. 611 - 681
Published: Sept. 24, 2020
This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.
Language: Английский
Citations
293
Cell, Journal Year: 2021, Volume and Issue: 184(10), P. 2733 - 2749.e16
Published: April 16, 2021
Language: Английский
Citations
190
Nature, Journal Year: 2020, Volume and Issue: 590(7846), P. 451 - 456
Published: Dec. 23, 2020
Language: Английский
Citations
143
Current Biology, Journal Year: 2020, Volume and Issue: 31(4), P. 707 - 721.e7
Published: Dec. 10, 2020
The basal ganglia (BG) inhibit movements through two independent circuits: the striatal neuron-indirect and subthalamic nucleus-hyperdirect pathways. These pathways exert opposite effects onto external globus pallidus (GPe) neurons, whose functional importance as a relay has changed drastically with discovery of distinct cell types, namely prototypic arkypallidal neurons. However, little is known about synaptic connectivity scheme different GPe neurons toward both motor-suppressing pathways, well how changes in neuronal activity relate to locomotion inhibition. Here, we optogenetically dissect input organizations further define circuit mechanism behavioral outcome associated activation indirect or hyperdirect This work reveals that are part novel disynaptic feedback loop differentially recruited by broadcasts inhibitory control only when increase their activity.
Language: Английский
Citations
72
FEBS Journal, Journal Year: 2021, Volume and Issue: 289(8), P. 2263 - 2281
Published: May 12, 2021
The synaptic pathways in the striatum are central to basal ganglia functions including motor control, learning and organization, action selection, acquisition of skills, cognitive function, emotion. Here, we review role its connections performance. development new techniques record neuronal activity animal models disorders using neurotoxin, pharmacological, genetic manipulations revealing that underlie performance learning, as well how they altered by pathophysiological mechanisms. We discuss approaches can be used analyze complex particularly rodents, identify specific questions understanding striatal circuits mediate learning.
Language: Английский
Citations
56
Frontiers in Synaptic Neuroscience, Journal Year: 2023, Volume and Issue: 14
Published: Jan. 19, 2023
The direct and indirect striatal pathways form a cornerstone of the circuits basal ganglia. Dopamine has opponent affects on function these due to segregation D1- D2-dopamine receptors in spiny projection neurons giving rise pathways. An historical perspective is provided discovery dopamine receptor leading models how affect motor behavior.
Language: Английский
Citations
39
Neuron, Journal Year: 2023, Volume and Issue: 111(14), P. 2218 - 2231.e4
Published: May 18, 2023
Language: Английский
Citations
34
Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(12)
Published: March 15, 2023
Dopamine (DA) loss in Parkinson’s disease (PD) causes debilitating motor deficits. However, dopamine is also widely linked to reward prediction and learning, the contribution of dopamine-dependent learning movements that are impaired PD—which often do not lead explicit rewards—is unclear. Here, we used two distinct tasks dissociate dopamine’s acute motoric effects vs. its long-lasting, learning-mediated effects. In dopamine-depleted mice, task performance gradually worsened with exposure. Task experience was critical, as mice remained home cage during same period were relatively unimpaired when subsequently probed on task. Repeated replacement treatments acutely rescued deficits induced long-term rescue persisted despite treatment withdrawal. Surprisingly, both parkinsonian decline specific, implicating learning. D1R activation potently consolidated into rescue. Conversely, reduced D2R decline. either or prevented decline, restored balanced direct indirect striatal pathways. These findings suggest reinforcement maintenance movements—even leading rewards—are fundamental functions provide potential mechanisms for hitherto unexplained “long-duration response” by dopaminergic therapies PD.
Language: Английский
Citations
31
Biomedicines, Journal Year: 2021, Volume and Issue: 9(6), P. 647 - 647
Published: June 7, 2021
Dopamine (DA) is a behaviorally and clinically diverse neuromodulator that controls CNS function. DA plays major roles in many behaviors including locomotion, learning, habit formation, perception, memory processing. Reflecting this, dysregulation produces wide variety of cognitive symptoms seen neuropsychiatric diseases such as Parkinson’s, Schizophrenia, addiction, Alzheimer’s disease. Here, we review recent advances the systems neuroscience field explore advancing hypothesis DA’s behavioral function linked to disease deficits neural circuit-dependent manner. We survey different brain areas basal ganglia’s dorsomedial/dorsolateral striatum, ventral auditory hippocampus rodent models. Each these regions have reported functions and, correspondingly, reflecting role each also has support for being different. then focus on states Parkinson’s disease, Disease, emphasizing how afflictions are pathways. draw upon ideas selective vulnerability region-dependent physiology. These bodies work suggest channels may be dysregulated sets While great advances, fine definitive segregation pathways behavior remains seen. Future studies will required define necessity contribution functional plasticity striatal regions.
Language: Английский
Citations
43
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: Oct. 8, 2022
Abstract The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated perceptual decision-making, transforming stimuli to action outcomes. Despite its known connections diverse neurological conditions, dopaminergic modulation sensory striatal neuronal activity and behavioral influences remain unknown. We demonstrated that optogenetic inhibition projections from substantia nigra pars compacta specifically impairs mouse choice performance but not movement an frequency discrimination task. In vivo dopamine calcium imaging freely behaving mice revealed this projection modulates tone representations, tone-evoked release inversely correlated with evidence strength tones. Optogenetic D1-receptor expressing neurons pharmacological D1 receptors dampened accuracy. Our study uncovers a phasic mechanism within nigrostriatal system regulates decisions by modulating ongoing perception.
Language: Английский
Citations
33