Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells DOI Creative Commons
Hooman Bagheri, Hana Friedman,

Amanda Hadwen

et al.

Glia, Journal Year: 2024, Volume and Issue: 72(10), P. 1893 - 1914

Published: July 18, 2024

Myelin Basic Protein (MBP) is essential for both elaboration and maintenance of CNS myelin, its reduced accumulation results in hypomyelination. How different Mbp mRNA levels affect myelin dimensions across the lifespan how resident glial cells may respond to such changes are unknown. Here, investigate these questions, we used enhancer-edited mouse lines that accumulate ranging from 8% 160% wild type. In young mice, resulted corresponding decreases protein sheath thickness, confirming previously demonstrated rate-limiting role transcription control initial synthesis. However, despite maintaining lower line specific into old age, MBP thickness improved or fully normalized at rates defined by relative level. Sheath length, contrast, was affected only when were very low, demonstrating length not equally coupled Striking abnormalities structure also emerged with levels. Unexpectedly, an increase density all cell types arose response This investigation extends understanding plays elaboration, architecture, plasticity illuminates a novel axis crosstalk.

Language: Английский

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 DOI
Tal Iram, Fabian Kern, Achint Kaur

et al.

Nature, Journal Year: 2022, Volume and Issue: 605(7910), P. 509 - 515

Published: May 11, 2022

Language: Английский

Citations

151
Insights into Alzheimer’s disease from single-cell genomic approaches DOI
Mitchell H. Murdock, Li‐Huei Tsai

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(2), P. 181 - 195

Published: Jan. 2, 2023

Language: Английский

Citations

104
Overview of myelin, major myelin lipids, and myelin-associated proteins DOI Creative Commons

Alexander Kister,

Ilya Kister

Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 21, 2023

Myelin is a modified cell membrane that forms multilayer sheath around the axon. It retains main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects. In this review, we focus on aspects myelin composition are peculiar to structure and differentiate it more conventional with special attention its constituent components most common proteins: basic protein, proteolipid protein zero. We also discuss many-fold functions myelin, which include reliable electrical insulation axons ensure rapid propagation nerve impulses, provision trophic support along axon organization unmyelinated nodes Ranvier, well relationship between biology neurologic disease multiple sclerosis. conclude brief history discovery field outline questions for future research.

Language: Английский

Citations

64
A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain DOI Creative Commons
Leonardo Lupori, Valentino Totaro, Sara Cornuti

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(7), P. 112788 - 112788

Published: July 1, 2023

Perineuronal nets (PNNs) surround specific neurons in the brain and are involved various forms of plasticity clinical conditions. However, our understanding PNN role these phenomena is limited by lack highly quantitative maps distribution association with cell types. Here, we present a comprehensive atlas Wisteria floribunda agglutinin (WFA)-positive PNNs colocalization parvalbumin (PV) cells for over 600 regions adult mouse brain. Data analysis shows that PV expression good predictor aggregation. In cortex, dramatically enriched layer 4 all primary sensory areas correlation thalamocortical input density, their mirrors intracortical connectivity patterns. Gene identifies many PNN-correlated genes. Strikingly, PNN-anticorrelated transcripts synaptic genes, generalizing PNNs' as circuit stability factors.

Language: Английский

Citations

45
Human neuronal maturation comes of age: cellular mechanisms and species differences DOI
Jenelle L. Wallace, Alex A. Pollen

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 25(1), P. 7 - 29

Published: Nov. 23, 2023

Language: Английский

Citations

36
Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits DOI Creative Commons
Yuniesky Andrade‐Talavera, André Fisahn, Antonio Rodríguez Moreno

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2177 - 2188

Published: March 29, 2023

Abstract In the mammalian brain information processing and storage rely on complex coding decoding events performed by neuronal networks. These actions are based computational ability of neurons their functional engagement in assemblies where precise timing action potential firing is crucial. Neuronal circuits manage a myriad spatially temporally overlapping inputs to compute specific outputs that proposed underly memory traces formation, sensory perception, cognitive behaviors. Spike-timing-dependent plasticity (STDP) electrical rhythms suggested underlie such functions while physiological evidence assembly structures mechanisms driving both processes continues be scarce. Here, we review foundational current precision cooperative activity STDP rhythms, interactions, emerging role glial cells processes. We also provide an overview correlates discuss limitations controversies, future perspectives experimental approaches, application humans.

Language: Английский

Citations

33
Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury DOI
Weikang Luo, Zhaoyu Yang, Jun Zheng

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(42), P. 28894 - 28909

Published: Oct. 9, 2024

Self-assembly of hydrogels for mechanical support and drug delivery has been extensively researched in traumatic brain injury (TBI), where treatment options are limited. The chief challenge is that most self-assembled rely on high molecular carriers or the incorporation exogenous inactive substances as mediators. It difficult these systems to achieve clinical translation due concerns regarding biological safety. Here we report a small molecule hydrogel (GBR-gel) loading drugs (glycyrrhizic acid, berberine, rhein) originated from popular Chinese medicines without additional components under physiological conditions. In long run, GBR-gel possesses several advantages, including ease preparation, cost-effectiveness, biocompatibility. As proof-of-concept, allows prompt administration at site exert potent pharmacodynamic effects. Further single-cell RNA sequencing experimental validation indicated can effectively rescue suppressed glutamatergic synapse pathway after TBI, thereby attenuating inflammatory responses neural impairments. Our work provides an alternative strategy timely intervention TBI.

Language: Английский

Citations

10
Buyang huanwu decoction promotes remyelination via miR-760-3p/GPR17 axis after intracerebral hemorrhage DOI
Yang Wang, Zhe Yu,

Menghan Cheng

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118126 - 118126

Published: March 30, 2024

Language: Английский

Citations

9
A perspective on astrocyte regulation of neural circuit function and animal behavior DOI
Johannes Hirrlinger, Axel Nimmerjahn

Glia, Journal Year: 2022, Volume and Issue: 70(8), P. 1554 - 1580

Published: March 17, 2022

Studies over the past two decades have demonstrated that astrocytes are tightly associated with neurons and play pivotal roles in neural circuit development, operation, adaptation health disease. Nevertheless, precisely how integrate diverse neuronal signals, modulate structure function at multiple temporal spatial scales, influence animal behavior or disease through aberrant excitation molecular output remains unclear. This Perspective discusses new state-of-the-art approaches, including fluorescence indicators, opto- chemogenetic actuators, genetic targeting tools, quantitative behavioral assays, computational methods, might help resolve these longstanding questions. It also addresses complicating factors interpreting astrocytes' role regulation behavior, such as their heterogeneity, metabolism, inter-glial communication. Research on questions should provide a deeper mechanistic understanding of astrocyte-neuron assemblies' function, complex behaviors,

Language: Английский

Citations

38
Procyanidins Boost the Neuroprotective Effect of Minocycline for Intracerebral Haemorrhage DOI Open Access
Taoyang Yuan, Tianyou Wang, Jianhua Zhang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(49)

Published: July 25, 2023

Abstract Poor prognosis is often expected after the treatment of intracerebral haemorrhage (ICH) when approach lacks effective neuroprotective interventions. Minocycline (Mino) a promising clinical candidate for acute ICH therapy that mainly inhibits activation microglia/macrophages. However, to address iron neurotoxicity, ferroptosis, and oxidative stress‐induced multiple neuroinjury mechanisms, effect minocycline still urgently needs be enhanced. To this issue, procyanidins (PACs), typical natural polyphenols, used improve Mino by constructing PACs‐Mino nanoparticles (NPs) using 3‐aminophenylboronic acid as crosslinker. The yielding NPs possessed improved antioxidant iron‐removing capacities in vitro. More importantly, exerted excellent therapeutic effects on ICH, showing activity resulting neurobehavioral recovery, an vitro cellular model vivo rat model. This study can provide general strategy uses polyphenols boost performance drugs treatment, results may further extended other injuries central nervous system, such brain injury spinal cord injury.

Language: Английский

Citations

21