mBio, Journal Year: 2021, Volume and Issue: 12(2)
Published: April 12, 2021
SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins. While these proteins are not required for growth in vitro , they can contribute to pathogenicity virus.
Language: Английский
Cell, Journal Year: 2020, Volume and Issue: 182(4), P. 812 - 827.e19
Published: July 3, 2020
A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become most prevalent form in global pandemic. Dynamic tracking of frequencies revealed a recurrent pattern G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even local epidemics where original D614 was well established prior to introduction variant. consistency this highly statistically significant, suggesting that may have fitness advantage. We found grows higher titer as pseudotyped virions. In infected individuals, is associated with lower RT-PCR cycle thresholds, suggestive upper respiratory tract viral loads, but not increased disease severity. These findings illuminate changes important for mechanistic understanding virus support continuing surveillance mutations aid development immunological interventions.
Language: Английский
Citations
4219
Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(4), P. 193 - 205
Published: Oct. 13, 2021
Language: Английский
Citations
1239
Cell, Journal Year: 2021, Volume and Issue: 184(13), P. 3426 - 3437.e8
Published: April 21, 2021
Language: Английский
Citations
518
Cell Reports Medicine, Journal Year: 2020, Volume and Issue: 1(6), P. 100098 - 100098
Published: Aug. 31, 2020
SARS-CoV-2 has recently been detected in feces, which indicates that wastewater may be used to monitor viral prevalence the community. Here, we use RT-qPCR for RNA over a 74-day time course. We show changes concentrations follow symptom onset gathered by retrospective interview of patients but precedes clinical test results. In addition, determine nearly complete (98.5%) genome sequence from and phylogenetic analysis infer ancestry. Collectively, this work demonstrates how can as proxy community sequencing genotyping strains circulating
Language: Английский
Citations
506
Science, Journal Year: 2020, Volume and Issue: 369(6501), P. 297 - 301
Published: May 29, 2020
Blighted Gotham Deaths caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in New York City (NYC) during the spring of 2020 have vastly exceeded those reported China and many other countries. What were early events that led to such a outbreak? Gonzalez-Reiche et al. sampled some patients seeking assistance February March at Mount Sinai Health System. Phylogenetic analysis virus sequences these people, who drawn from across NYC, showed had been independently introduced times Europe elsewhere United States. Subsequent clusters community transmission occurred. The focus infection NYC is marker role this city plays as two-way hub for human movement. Science issue p. 297
Language: Английский
Citations
428
Nature Human Behaviour, Journal Year: 2020, Volume and Issue: 4(8), P. 856 - 865
Published: July 31, 2020
Language: Английский
Citations
425
MMWR Morbidity and Mortality Weekly Report, Journal Year: 2020, Volume and Issue: 69(12), P. 347 - 352
Published: March 23, 2020
An estimated 30 million passengers are transported on 272 cruise ships worldwide each year* (1). Cruise bring diverse populations into proximity for many days, facilitating transmission of respiratory illness (2). SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) was first identified in Wuhan, China, December 2019 and has since spread to at least 187 countries territories. Widespread COVID-19 been reported as well (3). Passengers certain ship voyages might be aged ≥65 years, which places them greater risk severe consequences SARS-CoV-2 infection (4). During February-March 2020, outbreaks associated with three have caused more than 800 laboratory-confirmed cases among crew, including 10 deaths. Transmission occurred across multiple several ships. This report describes public health responses these poses a rapid disease, causing vulnerable population, aggressive efforts required contain spread. All persons should defer all travel during pandemic.
Language: Английский
Citations
406
Science, Journal Year: 2020, Volume and Issue: 370(6516), P. 564 - 570
Published: Sept. 10, 2020
Accurate understanding of the global spread emerging viruses is critical for public health responses and anticipating preventing future outbreaks. Here we elucidate when, where, how earliest sustained severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission networks became established in Europe North America. Our results suggest that rapid early interventions successfully prevented introductions virus from taking hold Germany United States. Other, later China to both Italy Washington state, States, founded European America networks. analyses demonstrate effectiveness measures onward show intensive testing contact tracing could have SARS-CoV-2 outbreaks becoming these regions.
Language: Английский
Citations
398
Nature Genetics, Journal Year: 2021, Volume and Issue: 53(6), P. 809 - 816
Published: May 10, 2021
Language: Английский
Citations
380
Nature Medicine, Journal Year: 2021, Volume and Issue: 27(3), P. 440 - 446
Published: Feb. 2, 2021
The first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in South Africa was identified on 5 March 2020, and by 26 the country full lockdown (Oxford stringency index of 90)1. Despite early response, November over 785,000 people were infected, which accounted for approximately 50% all known African infections2. In this study, we analyzed 1,365 near whole genomes report identification 16 new lineages SARS-CoV-2 isolated between 6 August 2020. Most these have unique mutations that not been elsewhere. We also show three (B.1.1.54, B.1.1.56 C.1) spread widely during wave, comprising ~42% infections at time. newly C lineage SARS-CoV-2, C.1, has nucleotide as compared with original Wuhan sequence, including one amino acid change spike protein, D614G (ref. 3), most geographically widespread end An African-specific lineage, B.1.106, April 2020 4), became extinct after nosocomial outbreaks controlled KwaZulu-Natal Province. Our findings genomic surveillance can be implemented a large scale to identify inform measures control SARS-CoV-2. Such presented study shown crucial 501Y.V2 variant December 5).
Language: Английский
Citations
375