Hallmarks of Cancer: New Dimensions

Cancer Discovery, Journal Year: 2022, Volume and Issue: 12(1), P. 31 - 46

Published: Jan. 1, 2022

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity phenotypes and genotypes into provisional set underlying principles. As knowledge mechanisms has progressed, other facets disease have emerged as potential refinements. Herein, prospect raised that phenotypic plasticity disrupted differentiation discrete hallmark capability, nonmutational epigenetic reprogramming polymorphic microbiomes both constitute distinctive enabling characteristics facilitate acquisition capabilities. Additionally, senescent cells, varying origins, may be added to roster functionally important cell types in tumor microenvironment. SIGNIFICANCE: Cancer daunting breadth scope its diversity, spanning genetics, tissue biology, pathology, response therapy. Ever more powerful experimental computational tools technologies are providing an avalanche "big data" about myriad manifestations diseases encompasses. integrative concept embodied helping distill this increasingly logical science, new dimensions presented perspective add value endeavor, fully understand development malignant progression, apply medicine.

Language: Английский

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Systemic immunity in cancer

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(6), P. 345 - 359

Published: April 9, 2021

Language: Английский

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The microbiome and human cancer

Science, Journal Year: 2021, Volume and Issue: 371(6536)

Published: March 25, 2021

Microbial roles in cancer formation, diagnosis, prognosis, and treatment have been disputed for centuries. Recent studies provocatively claimed that bacteria, viruses, and/or fungi are pervasive among cancers, key actors immunotherapy, engineerable to treat metastases. Despite these findings, the number of microbes known directly cause carcinogenesis remains small. Critically evaluating building frameworks such evidence light modern biology is an important task. In this Review, we delineate between causal complicit trace common themes their influence through host's immune system, herein defined as immuno-oncology-microbiome axis. We further review intratumoral approaches manipulate gut or tumor microbiome while projecting next phase experimental discovery.

Language: Английский

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Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(10), P. 625 - 637

Published: May 31, 2022

Language: Английский

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Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: July 1, 2021

Abstract Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show short-chain fatty acids (SCFAs) pentanoate and butyrate enhance anti-tumor cytotoxic T lymphocytes (CTLs) chimeric antigen receptor (CAR) through metabolic epigenetic reprograming. We in vitro treatment CTLs CAR with increases function mTOR as a central cellular sensor, inhibits class I histone deacetylase activity. This reprogramming results elevated production effector molecules such CD25, IFN-γ TNF-α, significantly enhances antigen-specific ROR1-targeting syngeneic murine melanoma pancreatic cancer models. Our shed light onto may used for enhancing immunity. Collectively, identify two SCFAs therapeutic utility context immunotherapy.

Language: Английский

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Cancer stem cell–immune cell crosstalk in tumour progression

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(8), P. 526 - 536

Published: June 8, 2021

Language: Английский

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Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

Cell, Journal Year: 2021, Volume and Issue: 184(21), P. 5338 - 5356.e21

Published: Oct. 1, 2021

Language: Английский

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Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 14, 2022

Abstract Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore, eliminating ROS the inflammatory site by antioxidant enzymes such as catalase and superoxide dismutase may effectively curb bowel disease (IBD). Here, Escherichia coli Nissle 1917 (ECN), a kind of oral probiotic, was genetically engineered to overexpress (ECN-pE) for treatment To improve bioavailability ECN-pE gastrointestinal tract, chitosan sodium alginate, effective biofilms, were used coat via layer-by-layer electrostatic self-assembly strategy. In mouse IBD model induced different chemical drugs, chitosan/sodium alginate coating (ECN-pE(C/A) 2 ) relieved inflammation repaired epithelial barriers colon. Unexpectedly, EcN-pE(C/A) could also regulate microbial communities abundance Lachnospiraceae _NK4A136 Odoribacter flora, which are important microbes maintain homeostasis. Thus, this study lays foundation development living therapeutic proteins using probiotics treat intestinal-related diseases.

Language: Английский

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Microbiome and cancer

Cancer Cell, Journal Year: 2021, Volume and Issue: 39(10), P. 1317 - 1341

Published: Sept. 9, 2021

Language: Английский

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Targeting the gut and tumor microbiota in cancer

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(4), P. 690 - 703

Published: April 1, 2022

Language: Английский

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