Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review DOI Creative Commons
Ji Qi, Sijia Li,

Jun-Bo Zhao

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: May 2, 2023

Background The incidence of sleep disorders in children with autism spectrum disorder (ASD) is very high. Sleep can exacerbate the development ASD and impose a heavy burden on families society. pathological mechanism complex, but gene mutations neural abnormalities may be involved. Methods In this review, we examined literature addressing genetic mechanisms ASD. databases PubMed Scopus were searched for eligible studies published between 2013 2023. Results Prolonged awakenings caused by following processes. Mutations MECP2, VGAT SLC6A1 genes decrease GABA inhibition neurons locus coeruleus, leading to hyperactivity noradrenergic prolonged HRH1, HRH2 , HRH3 heighten expression histamine receptors posterior hypothalamus, potentially intensifying histamine’s ability promote arousal. KCNQ3 PCDH10 cause atypical modulation amygdala impact orexinergic neurons, causing hyperexcitability hypothalamic orexin system. AHI1 ARHGEF10 UBE3A SLC6A3 affect dopamine synthesis, catabolism, reuptake processes, which elevate concentrations midbrain. Secondly, non-rapid eye movement closely related lack butyric acid, iron deficiency dysfunction thalamic reticular nucleus induced PTCHD1 alterations. Thirdly, HTR2A, SLC6A4 MAOA, MAOB TPH2 VMATs SHANK3, CADPS2 induce structural functional dorsal raphe (DRN) amygdala, disturb REM sleep. addition, melatonin levels ASMT MTNR1A MTNR1B mutations, along basal forebrain cholinergic lead abnormal sleep–wake rhythm transitions. Conclusion Our review revealed that circuits are strongly correlated Exploring underlying pathology significant further therapy.

Language: Английский

Sleep—A brain-state serving systems memory consolidation DOI Creative Commons
Svenja Brodt, Marion Inostroza, Niels Niethard

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1050 - 1075

Published: April 1, 2023

Language: Английский

Citations

175
Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans DOI Creative Commons
Maya Geva‐Sagiv, Emily A. Mankin,

Dawn Eliashiv

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(6), P. 1100 - 1110

Published: June 1, 2023

Memory consolidation during sleep is thought to depend on the coordinated interplay between cortical slow waves, thalamocortical spindles and hippocampal ripples, but direct evidence lacking. Here, we implemented real-time closed-loop deep brain stimulation in human prefrontal cortex tested its effects electrophysiology overnight of declarative memory. Synchronizing active phases endogenous waves medial temporal lobe (MTL) enhanced spindles, boosted locking brain-wide neural spiking activity MTL improved coupling ripples oscillations. Furthermore, synchronized accuracy recognition By contrast, identical without this precise time-locking was not associated with, sometimes even degraded, these electrophysiological behavioral effects. Notably, individual changes memory were highly correlated with Our results indicate that hippocampo-thalamocortical synchronization causally supports consolidation.

Language: Английский

Citations

74
Sleep and circadian rhythmicity as entangled processes serving homeostasis DOI
Paul Franken, Derk‐Jan Dijk

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 25(1), P. 43 - 59

Published: Dec. 1, 2023

Language: Английский

Citations

51
The sleep–circadian interface: A window into mental disorders DOI
Nicholas Meyer, Renske Lok, Christina Schmidt

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 23, 2024

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances alleviate psychopathology. Conversely, poor disrupt clock-controlled processes. Despite progress elucidating underlying mechanisms, a cohesive approach integrates dynamic interactions between disorder with both processes is lacking. This review synthesizes recent evidence for dysfunction as transdiagnostic contributor range disorders, an emphasis on biological mechanisms. We highlight observations from adolescent young adults, who at greatest risk developing whom early detection intervention promise benefit. In particular, we aim a) integrate factors implicated pathophysiology treatment mood, anxiety, psychosis spectrum perspective; b) need reframe existing knowledge adopt integrated which recognizes interaction factors; c) identify important gaps opportunities further research.

Language: Английский

Citations

28
Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions DOI Creative Commons
Anita Lüthi, Maiken Nedergaard

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Continuous sleep restores the brain and body, whereas fragmented harms cognition health. Microarousals (MAs), brief (3- to 15-s-long) wake intrusions into sleep, are clinical markers for various disorders. Recent rodent studies show that MAs during healthy non-rapid eye movement (NREM) driven by infraslow fluctuations of noradrenaline (NA) in coordination with electrophysiological rhythms, vasomotor activity, cerebral blood volume, glymphatic flow. hence part dynamics, raising questions about their biological roles. We propose bolster NREM sleep's benefits associated NA fluctuations, according an inverted U-shaped curve. Weakened noradrenergic as may occur neurodegenerative diseases or aids, reduce MAs, exacerbated caused stress fragment collapse signaling. suggest crucial restorative plasticity-promoting functions advance our insight normal pathological arousal dynamics from sleep.

Language: Английский

Citations

5
The human thalamus orchestrates neocortical oscillations during NREM sleep DOI Creative Commons
Thomas Schreiner, Elisabeth Kaufmann, Soheyl Noachtar

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 5, 2022

A hallmark of non-rapid eye movement sleep is the coordinated interplay slow oscillations (SOs) and spindles. Traditionally, a cortico-thalamo-cortical loop suggested to coordinate these rhythms: neocortically-generated SOs trigger spindles in thalamus that are projected back neocortex. Here, we used intrathalamic recordings from human epilepsy patients test this canonical interplay. We show anterior precede neocortical (peak -50 ms), whereas concurrently-recorded mediodorsal led by +50 ms). Sleep spindles, detected both thalamic nuclei, preceded their counterparts -100 ms) were initiated during early phases SOs. Our findings indicate an active role organizing rhythms neocortex highlight functional diversity nuclei humans. The coordination could have broad implications for mechanisms underlying memory consolidation.

Language: Английский

Citations

46
Electron Conductive and Transparent Hydrogels for Recording Brain Neural Signals and Neuromodulation DOI Open Access
Quanduo Liang,

Zhenzhen Shen,

Xiguang Sun

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(9)

Published: Dec. 23, 2022

Recording brain neural signals and optogenetic neuromodulations open frontiers in decoding information neurodegenerative disease therapeutics. Conventional implantable probes suffer from modulus mismatch with biological tissues an irreconcilable tradeoff between transparency electron conductivity. Herein, a strategy is proposed to address these tradeoffs, which generates conductive transparent hydrogels polypyrrole-decorated microgels as cross-linkers. The optical of the electrodes can be attributed special structures that allow light waves bypass microgel particles minimize their interaction. Demonstrated by probing hippocampus rat brains, biomimetic electrode shows prolonged capacity for simultaneous neuromodulation recording signals. More importantly, intriguing brain-machine interaction realized, involves signal input brain, generation, controlling limb behaviors. This breakthrough work represents significant scientific advancement toward developing therapies.

Language: Английский

Citations

45
REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex DOI Creative Commons
Ziyue Wang, Xiang Fei, Xiaotong Liu

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 12, 2022

Abstract The cerebral cortex is spontaneously active during sleep, yet it unclear how this global cortical activity spatiotemporally organized, and whether such not only reflects sleep states but also contributes to state switching. Here we report that cortex-wide calcium imaging in mice revealed distinct stage-dependent spatiotemporal patterns of activity, modulation could regulate In particular, elevated activation the occipital regions (including retrosplenial visual areas) became dominant rapid-eye-movement (REM) sleep. Furthermore, pontogeniculooccipital (PGO) wave-like was associated with transitions REM optogenetic inhibition strongly promoted deep by suppressing NREM-to-REM transition. Thus, whereas subcortical networks are critical for initiating maintaining wakefulness states, plays an role controlling states.

Language: Английский

Citations

42
REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation DOI Creative Commons
Han Qin, Ling Fu,

Tingliang Jian

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(23), P. 4000 - 4014.e6

Published: Oct. 21, 2022

Language: Английский

Citations

39
Human REM sleep recalibrates neural activity in support of memory formation DOI Creative Commons
Janna D. Lendner, Niels Niethard, Bryce A. Mander

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(34)

Published: Aug. 25, 2023

The proposed mechanisms of sleep-dependent memory consolidation involve the overnight regulation neural activity at both synaptic and whole-network levels. Now, there is a lack in vivo data humans elucidating if, how, sleep its varied stages balance activity, if such recalibration benefits memory. We combined electrophysiology with two-photon calcium imaging rodents as well intracranial scalp electroencephalography (EEG) to reveal key role for non-oscillatory brain during rapid eye movement (REM) mediate population dynamics. extent this REM predicted success consolidation, expressly modulation hippocampal-neocortical favoring remembering rather than forgetting. findings describe mechanism how human modulates enhance long-term

Language: Английский

Citations

29