Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review DOI Creative Commons
Ji Qi, Sijia Li,

Jun-Bo Zhao

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: May 2, 2023

Background The incidence of sleep disorders in children with autism spectrum disorder (ASD) is very high. Sleep can exacerbate the development ASD and impose a heavy burden on families society. pathological mechanism complex, but gene mutations neural abnormalities may be involved. Methods In this review, we examined literature addressing genetic mechanisms ASD. databases PubMed Scopus were searched for eligible studies published between 2013 2023. Results Prolonged awakenings caused by following processes. Mutations MECP2, VGAT SLC6A1 genes decrease GABA inhibition neurons locus coeruleus, leading to hyperactivity noradrenergic prolonged HRH1, HRH2 , HRH3 heighten expression histamine receptors posterior hypothalamus, potentially intensifying histamine’s ability promote arousal. KCNQ3 PCDH10 cause atypical modulation amygdala impact orexinergic neurons, causing hyperexcitability hypothalamic orexin system. AHI1 ARHGEF10 UBE3A SLC6A3 affect dopamine synthesis, catabolism, reuptake processes, which elevate concentrations midbrain. Secondly, non-rapid eye movement closely related lack butyric acid, iron deficiency dysfunction thalamic reticular nucleus induced PTCHD1 alterations. Thirdly, HTR2A, SLC6A4 MAOA, MAOB TPH2 VMATs SHANK3, CADPS2 induce structural functional dorsal raphe (DRN) amygdala, disturb REM sleep. addition, melatonin levels ASMT MTNR1A MTNR1B mutations, along basal forebrain cholinergic lead abnormal sleep–wake rhythm transitions. Conclusion Our review revealed that circuits are strongly correlated Exploring underlying pathology significant further therapy.

Language: Английский

Auditory stimulation during REM sleep modulates REM electrophysiology and cognitive performance DOI Creative Commons
Miguel Navarrete, Viviana Greco, Martyna Rakowska

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Feb. 16, 2024

REM sleep is critical for memory, emotion, and cognition. Manipulating brain activity during could improve our understanding of its function benefits. Earlier studies have suggested that auditory stimulation in might modulate time reduce rapid eye movement density. Building on this, we studied the cognitive effects electroencephalographic responses related to such stimulation. We used acoustic locked movements compared two overnight conditions (stimulation no-stimulation). evaluated impact this duration electrophysiology, as well REM-sensitive memory tasks: visual discrimination mirror tracing. Our results show decreases characterize improves performance task but detrimental tracing task. also observed increased beta-band decreased theta-band following Interestingly, these spectral changes were associated with behavioural performance. These can suggest different processes underpin divergent impacts

Language: Английский

Citations

6
The effects of Tai Chi exercise on sleep quality among the elderly: a study based on polysomnographic monitoring DOI Creative Commons
Chao Wang, Tao Jiang, Hansen Li

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Background Sleep disorders contribute to an increased risk of depression, cardiovascular issues, and various other diseases among older individuals. Consequently, enhancing the sleep quality this demographic population has become a pressing concern. The objective study was investigate influence 8-week Tai Chi exercise intervention in adults. Methods Sixty individuals aged 60 years above, recruited from community around Southwest University Beibei District, Chongqing City, were randomly assigned either control group (30 participants) or participants). adhered their normal daily routines during experimental period, while engaged 60-min practice three times week for 8 weeks. assessed using Pittsburgh Quality Index (PSQI), Insomnia Severity (ISI), Epworth Sleepiness Scale (ESS). Additionally, Polysomnographic Monitoring System (PSG) employed monitor process before after intervention. Results After experiment, significant differences observed PSQI IEI scores between groups ( p < 0.05). In group, pre-post comparisons revealed increase time spent bed 0.05), total non-REM stage 2 Conclusion findings indicate that may improve subjective reported quality. addition, alleviate general drowsiness, extend duration, optimize structure. be suitable

Language: Английский

Citations

6
Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1 DOI Creative Commons
Yun Li,

Shaowei Hou,

Feixiang Li

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 211, P. 110945 - 110945

Published: April 10, 2024

Sleep fragmentation (SF) is a common sleep problem experienced during the perioperative period by older adults, and associated with postoperative cognitive dysfunction (POCD). Increasing evidence indicates that delta-wave activity non-rapid eye movement (NREM) involved in sleep-dependent memory consolidation hippocampal theta oscillations are related to spatial exploratory memory. Recovery (RS), self-regulated state of homeostasis, enhances power performance sleep-deprived mice. However, it remains unclear whether RS therapy has positive effect on changes following SF mouse models. Therefore, this study aimed explore preoperative can alleviate deficits aged mice SF. A model 24-h combined laparotomy-induced POCD was established 18-month-old Aged were treated 6-h surgery, respectively. The hippocampus-dependent function investigated using behavioral tests, electroencephalography (EEG), local field potential (LFP), magnetic resonance imaging, neuromorphology. Mice underwent surgery exhibited severe impairment; impaired could be alleviated treatment. In addition, increased NREM sleep; enhanced EEG LFP oscillation CA1; improved perfusion, microstructural integrity, neuronal damage. Taken together, these results provide may ameliorate severity aggravated enhancing delta slow-wave oscillation, ameliorating reduction regional cerebral blood flow white matter microstructure integrity hippocampus.

Language: Английский

Citations

6
Gene therapy for Lafora disease in the Epm2a mouse model DOI
Luis Zafra-Puerta, Nerea Iglesias-Cabeza, Daniel F. Burgos

et al.

Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(7), P. 2130 - 2149

Published: May 24, 2024

Language: Английский

Citations

6
Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review DOI Creative Commons
Ji Qi, Sijia Li,

Jun-Bo Zhao

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: May 2, 2023

Background The incidence of sleep disorders in children with autism spectrum disorder (ASD) is very high. Sleep can exacerbate the development ASD and impose a heavy burden on families society. pathological mechanism complex, but gene mutations neural abnormalities may be involved. Methods In this review, we examined literature addressing genetic mechanisms ASD. databases PubMed Scopus were searched for eligible studies published between 2013 2023. Results Prolonged awakenings caused by following processes. Mutations MECP2, VGAT SLC6A1 genes decrease GABA inhibition neurons locus coeruleus, leading to hyperactivity noradrenergic prolonged HRH1, HRH2 , HRH3 heighten expression histamine receptors posterior hypothalamus, potentially intensifying histamine’s ability promote arousal. KCNQ3 PCDH10 cause atypical modulation amygdala impact orexinergic neurons, causing hyperexcitability hypothalamic orexin system. AHI1 ARHGEF10 UBE3A SLC6A3 affect dopamine synthesis, catabolism, reuptake processes, which elevate concentrations midbrain. Secondly, non-rapid eye movement closely related lack butyric acid, iron deficiency dysfunction thalamic reticular nucleus induced PTCHD1 alterations. Thirdly, HTR2A, SLC6A4 MAOA, MAOB TPH2 VMATs SHANK3, CADPS2 induce structural functional dorsal raphe (DRN) amygdala, disturb REM sleep. addition, melatonin levels ASMT MTNR1A MTNR1B mutations, along basal forebrain cholinergic lead abnormal sleep–wake rhythm transitions. Conclusion Our review revealed that circuits are strongly correlated Exploring underlying pathology significant further therapy.

Language: Английский

Citations

13