Sleep and circadian disturbances in children with neurodevelopmental disorders

Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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Comorbidity Between Mental and Physical Disorders in Children and Adolescents: Identification, Management, and Treatment

Published: Jan. 1, 2025

Language: Английский

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Melatonin Interventions in Autism Spectrum Disorder: Sleep Regulation, Behavioral Outcomes, and Challenges Across the Lifespan

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Data independent acquisition proteomics and machine learning reveals that proteins associated with immunity are potential molecular markers for early diagnosis of autism

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120238 - 120238

Published: April 1, 2025

Early diagnosis of autism is critical to its treatment, but so far, there no clear molecular marker for early in children. We used data independent acquisition (DIA) mass spectrometry compare protein expression serum from 99 Chinese children with spectrum disorders 70 healthy identified 347 downregulated and 394 upregulated proteins. Based on bioinformatics analysis, differential proteins were enriched the immune system, disease, cell motility, focal adhesion. Machine learning revealed a model eight (IGH c1898_heavy_IGHV3-33_IGHD3-9_IGHJ4, LYZ, IGL c1860_light_IGLV8-61_IGLJ2, SERPINA10, IG c1421_light_IGKV1-27_IGKJ4, rheumatoid factor RF-ET1, c600_light_IGKV4-1_IGKJ4, SELL) that mostly associated immunity, accurate autism. The family was verified by logic-regression leave-one cross-validation method bidirectional feature screening. accuracy this 0.9527, kappa coefficient 0.9025. Our study showed immunity closely related onset can be screening patients. A SELL), which are

Language: Английский

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The Hidden Impact of ADHD Symptoms in Preschool Children with Autism: Is There a Link to Somatic and Sleep Disorders?

Behavioral Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 211 - 211

Published: March 6, 2024

Neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity (ADHD), do often present in comorbidity among them with other medical conditions, including sleep gastrointestinal (GI) disorders somatic complaints. An anonymous online survey based on standardized questionnaires (SDSC, KL-ASD, APSI, ROME V CRITERIA, CPRS, CBCL) was completed by the parents of 46 preschoolers diagnosed ASD. A high prevalence (47%) ADHD symptoms this population found, surpassing previous estimates. Sleep disturbances, especially difficulties initiating maintaining sleep-wake transition, are more pronounced ASD patients comorbid ADHD. Additionally, over 4 years old, there is a functional GI (Rome criteria: 38%). Parental stress significantly associated symptoms, symptoms. Comprehensive assessments considering both core neurodevelopmental comorbidities crucial for effective treatment strategies improved wellbeing affected individuals their families.

Language: Английский

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Exploring the mechanism of agarwood moxa smoke in treating sleep disorders based on GC–MS and network pharmacology

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 9, 2024

Background Agarwood moxibustion is a folk therapy developed by individuals of the Li nationality in China. There evidence that agarwood moxa smoke (AMS) generated during can treat sleep disorders via traditional Chinese medicines’ multiple target and pathway characteristics. However, specific components mechanisms involved have yet to be explored. Objective GC–MS (Gas Chromatography–Mass Spectrometry) network pharmacology were used investigate AMS’s molecular basis mechanism treating deprivation. Method was determine chemical composition AMS; component information collected from TCMSP (Traditional Medicine Systems Pharmacology), PubChem (Public Chemical Database), GeneCards (Human Gene DisGeNet (Database Genes Diseases) identify disease targets, JVenn (Joint Venn) common targets AMS disorders. STRING construct protein interaction network, Cytoscape 3.9.1 build multilevel diagram “core components-efficacy targets-action pathways,” imported into Metascape DAVID for GO (Gene Ontology) KEGG (Kyoto Encyclopedia Genomes) analyses Autodock docking. This research methodology therapeutic potential Moxa Smoke problems. Examining genes constituents offers insights processes disease. Result Nine active ingredients comprising anti-inflammatory substances antioxidants, such as caryophyllene p-cymene, found seven sleep-regulating signaling pathways eight linked 94 AMS, had strong binding with key targets. Key findings included known medicinal properties, eucalyptol, caryophyllene. An investigation revealed regulation disorders, shedding light on effectiveness enhancing quality. Conclusion may alleviate modulating cellular synaptic signaling, controlling hormone neurotransmitter pathways, etc. Understanding material action provides foundation future AMS. According study, improve quality modifying those who suffer might lead development innovative therapies fewer side effects.

Language: Английский

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Insomnia in Children Affected by Autism Spectrum Disorder: The Role of Melatonin in Treatment

Sleep Medicine, Journal Year: 2024, Volume and Issue: 119, P. 511 - 517

Published: May 24, 2024

Language: Английский

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PTCHD1 gene mutation/deletion: the cognitive-behavioral phenotyping of four case reports

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 15, 2024

Introduction X-linked PTCHD1 gene has recently been pointed as one of the most interesting candidates for involvement in neurodevelopmental disorders (NDs), such intellectual disability (ID) and autism spectrum disorder (ASD). encodes patched domain-containing protein 1 ( ), which is mainly expressed developing brain adult tissues. To date, major studies have focused on biological function gene, while mechanisms underlying neuronal alterations cognitive-behavioral phenotype associated with mutations still remain unclear. Methods With aim incorporating information clinical profile affected individuals enhancing characterization genotype–phenotype correlation, this study, we analyze features four (two children two adults) array-CGH detected a deletion or panel screening non-syndromal XLID (X-linked ID) variant. We define neuropsychological psychopathological profiles, providing quantitative data from standardized evaluations. The assessment consisted observations, structured interviews, parent/self-reported questionnaires. Results Our descriptive analysis align previous findings NDs. Specifically, our patients exhibited characterized by psychomotor developmental delay- ID varying severity. Interestingly, during early childhood was autistic-like symptomatology, interrelation no longer observed subjects. Furthermore, cohort did not display peculiar dysmorphic features, congenital abnormalities comorbidity epilepsy. Discussion shows that behavioral comorbidities along cognitive impairment interfere development, therefore contributing to severity mutation. Awareness professionals caregivers can promote prompt diagnosis well occupational enhancement interventions.

Language: Английский

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Noradrenergic and Dopaminergic Neural Correlates of Trait Anxiety: Unveiling the Impact of Maladaptive Emotion Regulation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Background Maladaptive emotion regulation plays a crucial role in the development and maintenance of elevated anxiety levels, both patients individuals with subclinical symptomatology. While pharmacological treatments for target dysregulation through dopaminergic, noradrenergic serotonergic systems, little is known about underlying mechanisms. Therefore, current study depicts association these neuromodulatory systems’ resting-state functioning trait-anxiety, investigating maladaptive regulation. Methods Amplitude low-frequency fluctuations (ALFF), fractional amplitude (fALFF), whole-brain functional connectivity (rs-FC) were obtained from ventral tegmental area (VTA), locus coeruleus (LC) dorsal raphe, correlated trait-anxiety self-reported (N = 60). Results Trait-anxiety was positively associated LC’s fALFF negatively VTA’s rs-FC left inferior parietal lobule (L-IPL) superior frontal gyrus (L-SFG). regions, fully mediating this association. VTA region, but not parietal, predicted its neural oscillations, an effect that paralleled by stronger dopaminergic innervation. Limitations Use external molecular datasets need replication patients. Conclusions Noradrenergic systems appear to contribute differently anxiety. noradrenaline likely acts more general mechanism, dysconnectivity frontoparietal control network may act as one mechanisms regulation, informing models on disorder development. Highlights shows positive activity emotional are linked VTA-frontoparietal mediates regulation’s Strength ALFF

Language: Английский

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Systemic heterogeneity in autism spectrum disorder revealed by individualized structural covariance network analysis

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 136, P. 111224 - 111224

Published: Dec. 18, 2024

Language: Английский

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