The brain–body energy conservation model of aging

Nature Aging, Journal Year: 2024, Volume and Issue: 4(10), P. 1354 - 1371

Published: Oct. 8, 2024

Language: Английский

---

Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety

Nature Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Language: Английский

---

Interplay between the brain and adipose tissue: a metabolic conversation

EMBO Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

---

Immuno-metabolic depression: from concept to implementation

The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 48, P. 101166 - 101166

Published: Dec. 18, 2024

Language: Английский

---

Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice

Molecular Metabolism, Journal Year: 2024, Volume and Issue: 87, P. 101996 - 101996

Published: July 22, 2024

In Western society, high-caloric diets rich in fats and sugars have fueled the obesity epidemic its related disorders. Disruption of body-brain communication, crucial for maintaining glucose energy homeostasis, arises from both obesogenic genetic factors, leading to metabolic Here, we investigate role hypothalamic tanycyte shuttles between pituitary portal blood third ventricle cerebrospinal fluid regulating balance.

Language: Английский

---

Hypothalamic GABAergic Neurons Expressing Cellular Retinoic Acid Binding Protein 1 (CRABP1) Are Sensitive to Metabolic Status and Liraglutide in Male Mice

Neuroendocrinology, Journal Year: 2024, Volume and Issue: 114(7), P. 681 - 697

Published: Jan. 1, 2024

<b><i>Introduction:</i></b> Owing to their privileged anatomical location, neurons of the arcuate nucleus hypothalamus (ARC) play critical roles in sensing and responding metabolic signals such as leptin glucagon-like peptide 1 (GLP-1). In addition well-known proopiomelanocortin (POMC)- agouti-related (AgRP)-expressing neurons, subpopulations GABAergic are emerging key regulators energy balance. However, precise identity these is still elusive. Here, we identified characterized molecular signature a novel population ARC expressing <i>Cellular retinoic acid binding protein 1</i> (<i>Crabp1</i>). <b><i>Methods:</i></b> Using combination immunohistochemistry situ hybridization techniques, investigated expression <i>Crabp1</i> across mouse brain <i>Crabp1</i>^ARC neurons. We also determined whether sensitive fasting, leptin, GLP1R agonism by assessing cFOS immunoreactivity marker neuronal activity. <b><i>Results:</i></b> represent robustly enriched distinct from prototypical melanocortin <i>Crabp1</i>^<i>ARC</i> overlap with three yet uncharacterized <i>Htr3b</i>, <i>Tbx19</i>, <i>Tmem215</i>. Notably, express receptors for hormones activity modulated nutritional state agonism. <b><i>Conclusion:</i></b> heterogeneous status.

Language: Английский

---

Neural mechanisms and health implications of food cravings during pregnancy

Advances in genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Feb. 5, 2025

G-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly regulation of food intake and energy metabolism. This review provides an overview classical loss gain-of-function studies on GPCRs related to feeding metabolism, with focus emerging cell-type-specific investigations. These reveal that diverse GPCR-expressing neuronal populations are intricately linked balance. We also discuss recent findings highlight interaction distinct peptide-GPCR systems modulating complex behaviors.

Language: Английский

---

AgRP neurons shape the sperm small RNA payload

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 28, 2025

Abstract Paternal dietary patterns and obesity can affect offspring through epigenetic signals in sperm RNA. By activating hypothalamic Agouti-related peptide (AgRP) neurons mice to simulate obesity’s effects, we observed changes the small noncoding RNA payload of sperm. These alterations, particularly transfer RNA-derived RNAs (tsRNAs), are similar those induced by short-term high-fat diets, suggesting a common upstream regulatory mechanism involving AgRP that affects metabolic inheritance.

Language: Английский

---

Connecting the dots: Understanding and addressing the metabolic impact of antipsychotic and antidepressant medications

Annals of the New York Academy of Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Serious mental disorders such as schizophrenia and major depression are associated with considerable morbidity mortality, resulting in much shorter life expectancies those affected. The discovery of antipsychotic medications ushered improved health outcomes for people serious but also brought about increased due to their metabolic side effects, including obesity diabetes mellitus. Antidepressant have a more favorable effect profile, some can still cause weight gain hyperglycemia. In this narrative review, we discuss antidepressant medications’ mechanisms action, respective effectiveness treating psychosis depression, effects. addition, present therapeutic strategies minimizing cardiometabolic risks patients treated these by applying comprehensive, biopsychosocial approach.

Language: Английский

---