Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications DOI Creative Commons

Saiyang Xie,

Si‐Chi Xu,

Wei Deng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 14, 2023

Abstract Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure. The metabolic microenvironment has been identified as hallmark of malignancy, but recent studies have shed light on its role cardiovascular diseases (CVDs). Various pathways cardiomyocytes and noncardiomyocytes determine cellular senescence the heart. Metabolic alteration common process throughout cardiac degeneration. Importantly, involvement injuries, including failure myocardial ischemia infarction, reported. However, complexity among human hearts hinders development strategies that targets susceptibility. Advances over past decade linked with their reprogramming pathway aging, autophagy, oxidative stress, epigenetic modifications, chronic inflammation, myocyte systolic phenotype regulation. In addition, status involved crucial aspects biology, from fibrosis hypertrophy inflammation. further elucidation metabolism degeneration still needed. Thus, deciphering mechanisms underlying how impacts thought contribute novel interventions protect or even restore hearts. Here, we summarize emerging concepts about landscapes specific focuses why profile alters during could utilize current knowledge improve management aging.

Language: Английский

CAR-based therapies: opportunities for immuno-medicine beyond cancer DOI Open Access
Haig Aghajanian, Joel G. Rurik, Jonathan A. Epstein

et al.

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(2), P. 163 - 169

Published: Feb. 28, 2022

Language: Английский

Citations

91
Targeted modulation of immune cells and tissues using engineered biomaterials DOI Open Access
Parisa Yousefpour, Kaiyuan Ni, Darrell J. Irvine

et al.

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(2), P. 107 - 124

Published: Jan. 30, 2023

Language: Английский

Citations

85
In vivo human T cell engineering with enveloped delivery vehicles DOI Creative Commons
Jennifer Hamilton, Evelyn Chen,

Barbara S. Perez

et al.

Nature Biotechnology, Journal Year: 2024, Volume and Issue: 42(11), P. 1684 - 1692

Published: Jan. 11, 2024

Viruses and virally derived particles have the intrinsic capacity to deliver molecules cells, but difficulty of readily altering cell-type selectivity has hindered their use for therapeutic delivery. Here, we show that cell surface marker recognition by antibody fragments displayed on membrane-derived encapsulating CRISPR-Cas9 protein guide RNA can genome editing tools specific cells. Compared conventional vectors like adeno-associated virus rely evolved capsid tropisms encoded cargo, these Cas9-packaging enveloped delivery vehicles (Cas9-EDVs) leverage predictable antibody-antigen interactions transiently machinery selectively cells interest. Antibody-targeted Cas9-EDVs preferentially confer in cognate target over bystander mixed populations, both ex vivo vivo. By using multiplexed targeting direct human T enable generation genome-edited chimeric antigen receptor humanized mice, establishing a programmable modality with potential widespread utility.

Language: Английский

Citations

84
RNA therapeutics: updates and future potential DOI Open Access

Caroline Zhang,

Biliang Zhang

Science China Life Sciences, Journal Year: 2022, Volume and Issue: 66(1), P. 12 - 30

Published: Sept. 8, 2022

Language: Английский

Citations

83
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications DOI Creative Commons

Saiyang Xie,

Si‐Chi Xu,

Wei Deng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 14, 2023

Abstract Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure. The metabolic microenvironment has been identified as hallmark of malignancy, but recent studies have shed light on its role cardiovascular diseases (CVDs). Various pathways cardiomyocytes and noncardiomyocytes determine cellular senescence the heart. Metabolic alteration common process throughout cardiac degeneration. Importantly, involvement injuries, including failure myocardial ischemia infarction, reported. However, complexity among human hearts hinders development strategies that targets susceptibility. Advances over past decade linked with their reprogramming pathway aging, autophagy, oxidative stress, epigenetic modifications, chronic inflammation, myocyte systolic phenotype regulation. In addition, status involved crucial aspects biology, from fibrosis hypertrophy inflammation. further elucidation metabolism degeneration still needed. Thus, deciphering mechanisms underlying how impacts thought contribute novel interventions protect or even restore hearts. Here, we summarize emerging concepts about landscapes specific focuses why profile alters during could utilize current knowledge improve management aging.

Language: Английский

Citations

77