Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(49)

Published: Oct. 4, 2022

The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field cancer treatment. Herein, a new strategy based on triarylboron-doped acenethiophene scaffolds presented. attachment boron to linear acenethiophenes lowers lowest unoccupied molecular orbital (LUMO) energy, resulting redshifted absorptions and emissions. After encapsulation with amphiphilic polymer DSPE-mPEG2000 , it found that nanostructured BAnTh-NPs BTeTh-NPs (nanoparticles BAnTh BTeTh) shows hydroxyl radical (• OH) generation under ultrasound (US) irradiation aqueous solution almost no phototoxicity, which can overcome shortcomings O2 -dependent SDT avoid potential cutaneous phototoxicity issue. In vitro vivo therapeutic results validate boron-doped as enable high efficiency low good biocompatibility, indicating boron-functionalization acenes promising toward SDT.

Language: Английский

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Bioadhesive polymer semiconductors and transistors for intimate biointerfaces

Science, Journal Year: 2023, Volume and Issue: 381(6658), P. 686 - 693

Published: Aug. 10, 2023

The use of bioelectronic devices relies on direct contact with soft biotissues. For transistor-type devices, the semiconductors that need to have interfacing biotissues for effective signal transduction do not adhere well wet tissues, thereby limiting stability and conformability at interface. We report a bioadhesive polymer semiconductor through double-network structure formed by brush redox-active semiconducting polymer. resulting film can form rapid strong adhesion tissue surfaces together high charge-carrier mobility ~1 square centimeter per volt second, stretchability, good biocompatibility. Further fabrication fully transistor sensor enabled us produce high-quality stable electrophysiological recordings an isolated rat heart in vivo muscles.

Language: Английский

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Designing nanohesives for rapid, universal, and robust hydrogel adhesion

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 4, 2023

Abstract Nanoparticles-based glues have recently been shown with substantial potential for hydrogel adhesion. Nevertheless, the transformative advance in hydrogel-based application places great challenges on rapidity, robustness, and universality of achieving adhesion, which are rarely accommodated by existing nanoparticles-based glues. Herein, we design a type nanohesives based modulation mechanics surface chemical activation nanoparticles. The can form robust adhesion seconds, to arbitrary engineering solids biological tissues without any pre-treatments. A representative machine demonstrates tough compliant between dynamic sensors via nanohesives, guaranteeing accurate stable blood flow monitoring vivo. Combined their biocompatibility inherent antimicrobial properties, provide promising strategy field engineering.

Language: Английский

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Bioadhesive Technology Platforms

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 14084 - 14118

Published: Nov. 16, 2023

Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease minimal damage. These materials present numerous opportunities for tissue repair biomedical device integration, creating a broad landscape of applications that captivated clinical scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, efficient signal communication. In this Review, we delve into these pivotal aspects bioadhesive design, highlight latest advances applications, identify lie ahead bioadhesives multifunctional technology platforms.

Language: Английский

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Soft Electronics for Health Monitoring Assisted by Machine Learning

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 15, 2023

Abstract Due to the development of novel materials, past two decades have witnessed rapid advances soft electronics. The electronics huge potential in physical sign monitoring and health care. One important advantages is forming good interface with skin, which can increase user scale improve signal quality. Therefore, it easy build specific dataset, performance machine learning algorithm. At same time, assistance algorithm, become more intelligent realize real-time analysis diagnosis. machining algorithms complement each other very well. It indubitable that will bring us a healthier world near future. this review, we give careful introduction about new material, physiological detected by devices, devices assisted Some materials be discussed such as two-dimensional carbon nanotube, nanowire, nanomesh, hydrogel. Then, sensors according types (pulse, respiration, human motion, intraocular pressure, phonation, etc.). After that, various reviewed, including some classical powerful neural network algorithms. Especially, device introduced carefully. Finally, outlook, challenge, conclusion system powered algorithm discussed.

Language: Английский

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Temperature-Mediated Phase Separation Enables Strong yet Reversible Mechanical and Adhesive Hydrogels

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13948 - 13960

Published: July 10, 2023

Hydrogels with strong yet reversible mechanical and adhesive properties fabricated in a facile friendly manner are important for engineering intelligent electronics applications but challenging to create control. Existing approaches preparing hydrogels involve complicated pretreatments produce that suffer from limited skin applicability. Copolymerized expected present an intriguing target this field by means of thermoresponsive features, while the perceived intrinsic flaws brittleness, easy fracture, weak adhesion enervate development prospects. Herein, we report hydrogel using cellulose nanofibrils simultaneously address multiple dilemmas inspired temperature-mediated phase separation strategy. This strategy applies temperature-driven formation dissociation hydrogen bonds between common copolymers trigger onset termination dynamically on-demand properties. The resulting exhibits up 96.0% (117.2 J/m2 vs 4.8 interfacial toughness) 85.7% (0.02 MPa 0.14 stiffness) tunability when worked on skin, respectively. Our offers promising, simple, efficient way directly achieve robust performance one step biomass resources, implications could go beyond hydrogels.

Language: Английский

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Low-impedance tissue-device interface using homogeneously conductive hydrogels chemically bonded to stretchable bioelectronics

Science Advances, Journal Year: 2024, Volume and Issue: 10(12)

Published: March 20, 2024

Stretchable bioelectronics has notably contributed to the advancement of continuous health monitoring and point-of-care type care. However, microscale nonconformal contact locally dehydrated interface limit performance, especially in dynamic environments. Therefore, hydrogels can be a promising interfacial material for stretchable due their unique advantages including tissue-like softness, water-rich property, biocompatibility. there are still practical challenges terms electrical homogeneity, monolithic integration with devices. Here, we report synthesis homogeneously conductive polyacrylamide hydrogel an exceptionally low impedance (~21 ohms) reasonably high conductivity (~24 S/cm) by incorporating polyaniline-decorated poly(3,4-ethylenedioxythiophene:polystyrene). We also establish robust adhesion (interfacial toughness: ~296.7 J/m

Language: Английский

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Reduction of Platinum(IV) Prodrug Hemoglobin Nanoparticles with Deeply Penetrating Ultrasound Radiation for Tumor‐Targeted Therapeutically Enhanced Anticancer Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(22)

Published: March 24, 2023

The development of PtIV prodrugs that are reduced into the therapeutically active PtII species within tumor microenvironment has received much research interest. In order to provide spatial and temporal control over treatment, there is a high demand for compounds could be selectively activated upon irradiation. Despite recent progress, majority complexes excited with ultraviolet or blue light, limiting use such superficial application. To overcome this limitation, herein, first example prodrug nanoparticles deeply penetrating ultrasound radiation reported, enabling treatment deep-seated large tumors. were found accumulate inside mouse colon carcinoma intravenous injection able eradicate exposure radiation.

Language: Английский

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Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 6, 2023

With advances in tissue engineering and bioelectronics, flexible electronic hydrogels that allow conformal integration, online precision diagnosis, simultaneous regeneration are expected to be the next-generation platform for treatment of myocardial infarction. Here, we report a functionalized polyaniline-based chronological adhesive hydrogel patch (CAHP) achieves spatiotemporally selective embedded integration with moist dynamic epicardium surface. Significantly, CAHP has high adhesion toughness, rapid self-healing ability, enhanced electrochemical performance, facilitating sensitive sensing cardiac mechanophysiology-mediated microdeformations improvement fibrosis-induced electrophysiology. As result, monitors diastolic-systolic amplitude rhythm infarcted myocardium while effectively inhibiting ventricular remodeling, promoting vascular regeneration, improving electrophysiological function through electrocoupling therapy. Therefore, this diagnostic therapeutic provides promising monitorable protocol disease.

Language: Английский

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