Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

Cell, Journal Year: 2023, Volume and Issue: 186(7), P. 1309 - 1327

Published: March 1, 2023

Language: Английский

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Neuroinflammation: An astrocyte perspective

Science Translational Medicine, Journal Year: 2023, Volume and Issue: 15(721)

Published: Nov. 8, 2023

Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles health and disease. Recent technologies have uncovered functional heterogeneity of astrocytes their extensive interactions with other cell types CNS. In this Review, we highlight intricate between astrocytes, CNS-resident cells, CNS-infiltrating as well potential therapeutic value context inflammation neurodegeneration.

Language: Английский

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Development and future of droplet microfluidics

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1135 - 1153

Published: Jan. 1, 2024

This review introduces the development of droplet microfluidics by explaining physical mechanisms generation, discussing various approaches in manipulating droplets, and summarizing key applications material science biological analyses.

Language: Английский

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The diversification of methods for studying cell–cell interactions and communication

Nature Reviews Genetics, Journal Year: 2024, Volume and Issue: 25(6), P. 381 - 400

Published: Jan. 18, 2024

Language: Английский

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Therapeutic induction of antigen-specific immune tolerance

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 24(5), P. 338 - 357

Published: Dec. 12, 2023

Language: Английский

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Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102160 - 102160

Published: Dec. 7, 2023

Language: Английский

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Disease-associated astrocyte epigenetic memory promotes CNS pathology

Nature, Journal Year: 2024, Volume and Issue: 627(8005), P. 865 - 872

Published: March 20, 2024

Language: Английский

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Inflammatory aspects of Alzheimer’s disease

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 148(1)

Published: Aug. 28, 2024

Language: Английский

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LIANA+ provides an all-in-one framework for cell–cell communication inference

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(9), P. 1613 - 1622

Published: Sept. 1, 2024

The growing availability of single-cell and spatially resolved transcriptomics has led to the development many approaches infer cell-cell communication, each capturing only a partial view complex landscape intercellular signalling. Here we present LIANA+, scalable framework built around rich knowledge base decode coordinated inter- intracellular signalling events from single- multi-condition datasets in both data. By extending unifying established methodologies, LIANA+ provides comprehensive set synergistic components study communication via diverse molecular mediators, including those measured multi-omics is accessible at https://github.com/saezlab/liana-py with extensive vignettes ( https://liana-py.readthedocs.io/ ) an all-in-one solution inference.

Language: Английский

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Microglia as integrators of brain-associated molecular patterns

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(5), P. 358 - 370

Published: April 23, 2024

Language: Английский

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