A systems view of the vascular endothelium in health and disease

Cell, Journal Year: 2024, Volume and Issue: 187(18), P. 4833 - 4858

Published: Sept. 1, 2024

Language: Английский

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Emerging epigenetic insights into aging mechanisms and interventions

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(2), P. 157 - 172

Published: Jan. 11, 2024

Language: Английский

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The spleen in ischaemic heart disease

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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A heart-brain-spleen axis controls cardiac remodeling to hypertensive stress

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord

Nature, Journal Year: 2023, Volume and Issue: 624(7992), P. 611 - 620

Published: Oct. 31, 2023

Language: Английский

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Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence

Nature Aging, Journal Year: 2024, Volume and Issue: 4(11), P. 1562 - 1581

Published: Sept. 12, 2024

The accumulation and systemic propagation of senescent cells contributes to physiological aging age-related pathology. However, which cell types are most susceptible the aged milieu could be responsible for senescence has remained unclear. Here we found that physiologically bone marrow monocytes/macrophages (BMMs) propagate multiple tissues, through extracellular vesicles (EVs), drive age-associated dysfunction in mice. We identified peroxisome proliferator-activated receptor α (PPARα) as a target microRNAs within BMM-EVs regulates downstream effects on dysfunction. Demonstrating therapeutic potential, report treatment with PPARα agonist fenofibrate effectively restores tissue homeostasis Suggesting conservation humans, cohort study 7,986 participants, use is associated reduced risk chronic disease higher life expectancy. Together, our findings establish BMMs can distant tissues cause dysfunction, they provide supportive evidence extend healthy lifespan.

Language: Английский

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Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases

JACC Basic to Translational Science, Journal Year: 2024, Volume and Issue: 9(4), P. 522 - 534

Published: April 1, 2024

The prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a hallmark aging, is characterized by irreversible cell cycle arrest and the manifestation senescence-associated secretory phenotype, which has emerged as significant contributor to mortality, spectrum chronic ailments. An increasing body preclinical clinical research established connections between age-related cardiac vascular pathologies. This review comprehensively outlines studies delving into detrimental impact senescence on various diseases, encompassing systemic atherosclerosis (including coronary artery disease, stroke, peripheral arterial disease), well conditions such hypertension, congestive heart failure, arrhythmias, valvular diseases. In addition, we have demonstrating beneficial effects senolytics—a class drugs designed eliminate senescent cells selectively across diverse disease scenarios. Finally, address knowledge gaps influence systems discuss future trajectory strategies targeting for

Language: Английский

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Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

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Advances in cardiac tissue engineering and heart‐on‐a‐chip

Journal of Biomedical Materials Research Part A, Journal Year: 2023, Volume and Issue: 112(4), P. 492 - 511

Published: Nov. 1, 2023

Abstract Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded new biomaterial development as well the employment of innovative fabrication techniques that enable precise control mechanical, electrical, structural properties tissues being modelled. The elongated structure cardiomyocytes requires tuning substrate application biophysical stimuli to drive its mature phenotype. Landmark have already been achieved with induced pluripotent stem cell‐derived patches advanced human testing. Heart‐on‐a‐chip platforms now commonly used by a number pharmaceutical biotechnology companies. Here, we provide an overview physiology order better define requirements for functional recapitulation. We then discuss biomaterials most heart‐on‐a‐chip, followed discussion recent representative studies fields. outline significant challenges common fields, specifically: scalable platform standardization, improving cellular fidelity through effective vascularization, achieving adult maturation, ultimately developing cryopreservation protocols so available off shelf.

Language: Английский

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Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis

Circulation Research, Journal Year: 2024, Volume and Issue: 134(10), P. 1240 - 1255

Published: April 2, 2024

BACKGROUND: Pericytes are capillary-associated mural cells involved in the maintenance and stability of vascular network. Although aging is one main risk factors for cardiovascular disease, consequences on cardiac pericytes unknown. METHODS: In this study, we have combined single-nucleus RNA sequencing histological analysis to determine effects pericytes. Furthermore, conducted vivo vitro RGS5 (regulator G-protein signaling 5) loss function finally performed pericytes-fibroblasts coculture studies understand effect deletion neighboring fibroblasts. RESULTS: Aging reduced pericyte area capillary coverage murine heart. Single-nucleus further revealed that expression Rgs5 was from aged mice. showed impaired function, induced fibrosis, morphological changes characterized by a profibrotic gene signature different ECM (extracellular matrix) components growth factors, example, TGFB2 PDGFB . Indeed, culturing fibroblasts with supernatant RGS5-deficient their activation as evidenced increased αSMA (alpha smooth muscle actin) TGFβ (transforming factor beta)2-dependent mechanism. CONCLUSIONS: Our results identified crucial regulator during aging. The causes dysfunction induces myocardial hallmarks

Language: Английский

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