Mitochondria at the crossroads of health and disease

Cell, Journal Year: 2024, Volume and Issue: 187(11), P. 2601 - 2627

Published: May 1, 2024

Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence life. How their structure function are dynamically tuned in response to tissue-specific needs for energy, growth repair, renewal is being increasingly understood. respond intrinsic extrinsic stresses can alter cell organismal by inducing metabolic signaling within cells distal tissues. Here, we review how centrality mitochondrial functions manifests health a broad spectrum diseases aging.

Language: Английский

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The pleiotropic functions of reactive oxygen species in cancer

Nature Cancer, Journal Year: 2024, Volume and Issue: 5(3), P. 384 - 399

Published: March 22, 2024

Language: Английский

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Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1314 - 1314

Published: Jan. 21, 2024

Mitochondria are critical for providing energy to maintain cell viability. Oxidative phosphorylation involves the transfer of electrons from substrates oxygen produce adenosine triphosphate. also regulate proliferation, metastasis, and deterioration. The flow in mitochondrial respiratory chain generates reactive species (ROS), which harmful cells at high levels. stress caused by ROS accumulation has been associated with an increased risk cancer, cardiovascular liver diseases. Glutathione (GSH) is abundant cellular antioxidant that primarily synthesized cytoplasm delivered mitochondria. Mitochondrial glutathione (mGSH) metabolizes hydrogen peroxide within A long-term imbalance ratio mGSH can cause dysfunction, apoptosis, necroptosis, ferroptosis, may lead disease. This study aimed review physiological functions, anabolism, variations organ tissue accumulation, delivery GSH mitochondria relationships between levels, GSH/GSH disulfide (GSSG) ratio, programmed death, ferroptosis. We discuss diseases deficiency related therapeutics.

Language: Английский

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Why cells need iron: a compendium of iron utilisation

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Iron deficiency is globally prevalent, causing an array of developmental, haematological, immunological, neurological, and cardiometabolic impairments, associated with symptoms ranging from chronic fatigue to hair loss. Within cells, iron utilised in a variety ways by hundreds different proteins. Here, we review links between molecular activities regulated the pathophysiological effects deficiency. We identify specific enzyme groups, biochemical pathways, cellular functions, cell lineages that are particularly dependent. provide examples how deprivation influences multiple key systems tissues, including immunity, hormone synthesis, cholesterol metabolism. propose greater mechanistic understanding physiological processes may lead new therapeutic opportunities across range diseases.

Language: Английский

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The redox requirement and regulation during cell proliferation

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(5), P. 385 - 399

Published: Jan. 22, 2024

Language: Английский

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SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy

EBioMedicine, Journal Year: 2025, Volume and Issue: 112, P. 105533 - 105533

Published: Jan. 13, 2025

Language: Английский

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Solute carriers: The gatekeepers of metabolism

Cell, Journal Year: 2025, Volume and Issue: 188(4), P. 869 - 884

Published: Feb. 1, 2025

Language: Английский

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Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

Molecular Cell, Journal Year: 2023, Volume and Issue: 84(4), P. 802 - 810.e6

Published: Dec. 28, 2023

Language: Английский

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Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 18, 2024

Abstract Cysteine metabolism occurs across cellular compartments to support diverse biological functions and prevent the induction of ferroptosis. Though disruption cytosolic cysteine is implicated in this form cell death, it unknown whether substantial resident within mitochondria similarly pertinent Here, we show that despite rapid depletion intracellular upon loss extracellular cystine, cysteine-dependent synthesis Fe-S clusters persists lung cancer cells. This promotes a retention respiratory function maintenance mitochondrial redox state. Under these limiting conditions, find glutathione catabolism by CHAC1 supports pool sustain proteins critical oxidative metabolism. We disrupting cluster under restriction protects against ferroptosis, suggesting preservation antagonistic survival starved conditions. Overall, our findings implicate ferroptosis reveal mechanism resilience response nutrient stress.

Language: Английский

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Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis

Advances in cancer research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 44

Published: Jan. 1, 2024

Language: Английский

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